Cheng I Wang

US Patent:

20200216860, Jul 9, 2020

Filed:

Sep 5, 2018

Appl. No.:

16/644411

Inventors:

- Tarrytown NY, US
Andrew J. MURPHY - Croton-on-Hudson NY, US
Cheng WANG - White Plains NY, US

Assignee:

Regeneron Pharmaceuticals, Inc. - Tarrytown NY

International Classification:

C12N 15/86
C12N 9/22

Abstract:

The invention provides a recombinant RNA molecule comprising (i) a sequence of a gene-editing molecule mRNA, or a sequence of a functional fragment or derivative thereof, and (ii) at least one sequence of a coding or non-coding enrichment RNA, or a sequence of a functional fragment or derivative thereof, wherein the enrichment RNA, or functional fragment or derivative thereof, is capable of enhancing inclusion of the gene-editing molecule mRNA, or functional fragment or derivative thereof, into a retroviral particle. The invention provides a method of producing the retroviral particles of the invention, the method comprising culturing a packaging cell in conditions sufficient for the production of a plurality of retroviral particles.

US Patent:

20200196925, Jun 25, 2020

Filed:

Mar 5, 2020

Appl. No.:

16/810183

Inventors:

- New York NY, US
- Iowa City IA, US
Junyi Shang - New York NY, US
Zhixing Zhang - New York NY, US
Xuejun Wang - New York NY, US
Jaeyoung Yang - New York NY, US
Cheng Wang - New York NY, US
Pavana G. Rotti - Iowa City IA, US
John F. Engelhardt - Iowa City IA, US
Zhuang Hao - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY
DEPARTMENT OF ANATOMY AND CELL BIOLOGY - UNIVERSITY OF IOWA - Iowa City IA

International Classification:

A61B 5/145
G01N 33/74
G01N 27/414
H01L 21/02
H01L 29/16
H01L 23/38
A61B 5/1491
A61B 5/1477
A61B 5/00
H01L 51/05

Abstract:

A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.

US Patent:

20200154684, May 21, 2020

Filed:

Jun 27, 2018

Appl. No.:

16/625168

Inventors:

- Tarrytown NY, US
Viktoria Gusarova - Pleasantville NY, US
Cheng Wang - White Plains NY, US
Christos Kyratsous - Irvington NY, US
Terra Potocky - Dobbs Ferry NY, US
Katherine Cygnar - New York NY, US
Joel Martin - Putnam Valley NY, US

International Classification:

A01K 67/027
A61K 49/00
C07K 14/705

Abstract:

Non-human animal cells and non-human animals comprising a humanized Asgr1 locus and methods of using such non-human animal cells and non-human animals are provided. Non-human animal cells or non-human animals comprising a humanized Asgr1 locus express a human ASGR1 protein or an Asgr1 protein, fragments of which are from human ASGR1. Methods are provided for using such non-human animals comprising a humanized Asgr1 locus to assess in vivo efficacy of human-ASGR1-mediated delivery of therapeutic molecules or therapeutic complexes to the liver and to assess the efficacy of therapeutic molecules or therapeutic complexes acting via human-ASGR1-mediated mechanisms.

US Patent:

20200140491, May 7, 2020

Filed:

Jun 27, 2018

Appl. No.:

16/625189

Inventors:

- Tarrytown NY, US
Andrew J. Murphy - Croton-on-Hudson NY, US
Cheng Wang - White Plains NY, US
Leah Sabin - Goldens Bridge NY, US

International Classification:

C07K 14/005
C12N 7/00
C07K 16/08
C12N 15/63

Abstract:

Provided herein are compositions and methods for retargeting recombinant viral capsid proteins/capsids/vectors, e.g., in vivo, with a multispecific binding molecule, such as a bispecific antibody, that specifically binds a heterologous epitope displayed by the capsid protein and a protein expressed on the cell of interest for the targeted delivery of a nucleotide of interest.

US Patent:

20190300612, Oct 3, 2019

Filed:

Jul 20, 2017

Appl. No.:

16/318944

Inventors:

- Greenfield IN, US
DALE Lincoln LUDWIG - Rockaway NJ, US
Juqun SHEN - Flushing NY, US
Cheng WANG - Forest Hills NY, US

International Classification:

C07K 16/28

Abstract:

The present disclosure relates to anti-canine platelet derived growth factor receptor alpha antibodies binding to canine platelet derived growth factor receptor alpha.

US Patent:

20180368743, Dec 27, 2018

Filed:

Jun 19, 2018

Appl. No.:

16/012527

Inventors:

- New York NY, US
- Iowa City IA, US
Junyi Shang - New York NY, US
Zhixing Zhang - New York NY, US
Xuejun Wang - New York NY, US
Jaeyoung Yang - New York NY, US
Cheng Wang - New York NY, US
Pavana G. Rotti - Iowa City IA, US
John F. Engelhardt - Iowa City IA, US
Zhuang Hao - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW NEW YORK - New York NY
Department of Anatomy and Cell Biology - Universit y of Iowa - Iowa City IA

International Classification:

A61B 5/145
G01N 33/74
H01L 51/00
A61B 5/1477
A61B 5/1491
H01L 23/38
H01L 29/16
H01L 21/02
G01N 27/414

Abstract:

A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.

US Patent:

20180355017, Dec 13, 2018

Filed:

Jun 6, 2018

Appl. No.:

16/001717

Inventors:

- Tarrytown NY, US
Katherine Cygnar - New York NY, US
Christopher Schoenherr - Piermont NY, US
Christos Kyratsous - Irvington NY, US
Cheng Wang - White Plains NY, US

International Classification:

C07K 14/705
C12N 9/14
C12N 9/24
C07K 16/28

Abstract:

Compositions and methods for treating enzyme-deficiency diseases are disclosed. Multidomain therapeutic proteins containing an internalization effector binding domain and a lysosomal replacement enzyme activity are disclosed. The multidomain therapeutic proteins are capable of entering cells, segregating to the lysosome, and delivering the replacement enzyme activity to the lysosome.

US Patent:

20170350882, Dec 7, 2017

Filed:

Aug 21, 2017

Appl. No.:

15/682191

Inventors:

- New York NY, US
Yibo Zhu - New York NY, US
Junyi Shang - New York NY, US
Zhixing Zhang - New York NY, US
Xuejun Wang - New York NY, US
Jaeyoung Yang - New York NY, US
Cheng Wang - New York NY, US

Assignee:

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

International Classification:

G01N 33/543
G01N 27/414
B01L 3/00
G01N 33/53

Abstract:

A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at least one aptamer functionalized on a surface of the graphene. The at least one aptamer can be adapted for binding to the target analyte. Binding of the target analyte to the at least one aptamer can alter the conductance of the graphene.