Cheng Wang

US Patent:

7122677, Oct 17, 2006

Filed:

Nov 12, 2002

Appl. No.:

10/292618

Inventors:

Gregory A. Reichard - Ann Arbor MI, US
Sunil Paliwal - Scotch Plains NJ, US
Neng-Yang Shih - North Caldwell NJ, US
Dong Xiao - Warren NJ, US
Sapna Majmundar Shah - Jamesburg NJ, US
Cheng Wang - Summit NJ, US
Michelle Laci Wrobleski - Whitehouse Station NJ, US

Assignee:

Scherig Corporation - Kenilworth NJ

International Classification:

C07D 207/00
C07D 209/96
C07D 225/00
C07D 215/00
A01N 57/00

US Classification:

548407, 540450, 540451, 540453, 540466, 540531, 540543, 540609, 546 16, 546 19, 546 20, 546229, 546236, 514 79, 514 85, 514 91, 548408, 548410

Abstract:

A NKantagonist having the formula (I), wherein Arand Arare optionally substituted phenyl or heteroaryl, Xis an ether, thio or imino linkage, Rand Rare not both H or alkyl, and the remaining variables are as defined in the in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceuticals compositions. Methods of treatment and combinations with other agents are also disclosed.

US Patent:

20130023503, Jan 24, 2013

Filed:

Sep 24, 2012

Appl. No.:

13/625799

Inventors:

Gregory A. Reichard - Ann Arbor MI, US
Cheng Wang - Summit NJ, US
Dong Xiao - Warren NJ, US
Neng-Yang Shih - Warren NJ, US
Juan D. Arredondo - Montclair NJ, US
Michelle Laci Wrobleski - Whitehouse Station NJ, US
Anandan Palani - Bridgewater NJ, US

Assignee:

OPKO Health, Inc. - Miami FL

International Classification:

A61K 31/40
C07D 403/04
A61K 31/4025
C07D 401/04
A61K 31/454
A61K 31/4545
C07D 413/12
A61K 31/5377
A61K 31/438
C07D 498/10
A61K 31/5386
A61K 31/56
A61P 11/00
A61P 11/14
A61P 29/00
A61P 17/00
A61P 27/02
A61P 25/24
A61P 25/22
A61P 25/32
A61P 25/30
A61P 25/08
A61P 25/18
A61P 25/28
A61P 1/00
A61P 9/10
A61P 3/04
A61P 3/10
A61P 25/06
A61P 25/00
A61P 13/10
A61P 1/08
A61P 11/06
C07D 207/14

US Classification:

514171, 548557, 514426, 548518, 514422, 546208, 514326, 546188, 514316, 544130, 5142372, 51421002, 544 71, 5142308

Abstract:

A NKantagonist having the formula (I),wherein Arand Arare optionally substituted phenyl or heteroaryl, Xis an ether, thio or imino linkage, Rand Rare not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

US Patent:

20170283434, Oct 5, 2017

Filed:

Jun 23, 2017

Appl. No.:

15/631613

Inventors:

- Miami FL, US
Gregory A. Reichard - Ann Arbor MI, US
Cheng Wang - Summit NJ, US
Dong Xiao - Warren NJ, US
Neng-Yang Shih - Warren NJ, US
Juan D. Arredondo - Montclair NJ, US
Michelle Laci Wrobleski - Whitehouse Station NJ, US
Anandan Palani - Bridgewater NJ, US

International Classification:

C07D 498/10
C07D 211/56
C07D 487/10
C07D 401/04
A61K 31/454
A61K 31/166
A61K 31/451
A61K 31/437
A61K 31/4375
A61K 31/537
C07D 211/60
A61K 31/573

Abstract:

A NKantagonist having the formula (I),wherein Arand Arare optionally substituted phenyl or heteroaryl, Xis an ether, thio or imino linkage, Rand Rare not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

US Patent:

20140336158, Nov 13, 2014

Filed:

Jul 25, 2014

Appl. No.:

14/341097

Inventors:

- Miami FL, US
Gregory A. Reichard - Ann Arbor MI, US
Cheng Wang - Summit NJ, US
Dong Xiao - Warren NJ, US
Neng-Yang Shih - Warren NJ, US
Juan D. Arredondo - Montclair NJ, US
Michelle Laci Wrobleski - Whitehouse Station NJ, US
Anandan Palani - Bridgewater NJ, US

International Classification:

C07D 498/10
A61K 31/40
C07D 403/04
A61K 31/4025
A61K 31/454
A61K 45/06
A61K 31/4545
C07D 211/56
A61K 31/5377
C07D 471/10
A61K 31/438
C07D 207/50
C07D 401/04

US Classification:

514171, 548557, 514426, 548518, 514422, 546208, 514326, 546188, 514316, 544130, 5142372, 546 20, 514278, 546 16, 51421002, 544 71, 5142288

Abstract:

A NKantagonist having the formula (I),wherein Arand Arare optionally substituted phenyl or heteroaryl, Xis an ether, thio or imino linkage, Rand Rare not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.