The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention further provides methods of treating leukemia by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment including methotrexate.
The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention further provides methods of treating leukemia by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment including methotrexate.
Yiwen Li - Jersey City NJ, US Dan Lu - Montvale NJ, US David Surguladze - Chatham NJ, US James Robert Tonra - Skillman NJ, US
Assignee:
IMCLONE LLC - P.O. Box 6288 IN
International Classification:
A61K 39/395 C07K 16/18 A61P 35/00 A61P 35/02
US Classification:
4241391, 5303879, 5303917, 5303913
Abstract:
The present invention provides fully human antibodies that specifically bind to human FLT3 within extracellular domains 4 or 5 with high affinity. The invention further provides methods of treating leukemia by administering an effective amount of an antibody either alone or in combination with an anti-cancer agent or treatment including methotrexate.
- NEW YORK NY, US Zhenping Zhu - Woodcliff Lake NJ, US Yan Wu - Doylestown PA, US Stella A. Martomo - Edgewater NJ, US Zhaojing Zhong - Bronx NY, US Dan Lu - Montvale NJ, US
International Classification:
A61B 17/70
Abstract:
The invention provides antibodies that specifically bind to PD-L1 and fusion molecules comprising PD-L1 binding proteins constructed with an IL 15 receptor-binding domain, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents inhibit PD-L1-mediated immunosuppression and enhance cell and cytokine mediated immunity for the treatment of neoplastic and infectious diseases.
- NEW YORK NY, US Dan Lu - Montvale NJ, US Zhanna Polonskaya - Mountainside NJ, US
International Classification:
C07K 16/28 A61K 45/06 A61K 39/395
Abstract:
The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.
- New York NY, US Zhenping ZHU - Woodcliff Lake NJ, US Yan WU - Doylestown PA, US Stella MARTOMO - Edgewater NJ, US Zhaojing ZHONG - Bronx NY, US Dan LU - Montvale NJ, US
International Classification:
C07K 16/28 A61K 47/48 C07K 14/54
Abstract:
The invention provides antibodies that specifically bind to PD-L1 and fusion molecules comprising PD-L1 binding proteins constructed with an IL15 receptor-binding domain, nucleic acid molecules encoding the same, and therapeutic compositions thereof. The agents inhibit PD-L1-mediated immunosuppression and enhance cell and cytokine mediated immunity for the treatment of neoplastic and infectious diseases.
The invention relates to antibodies that bind to VEGFR-2. The antibodies are used for treating neoplastic diseases, hyperproliferative disorders, and angiogenic disorders and can be used alone or in combination with other agents.
Name / Title
Company / Classification
Phones & Addresses
Dan Lu COO
D & L Technologies Motion Picture and Video Tape Production
2368 Arcdale Ave., City of Industry, CA 91748
Dan Dan Lu President
Brilliant Consulting Service, Inc
2601 S Baldwin Ave, Arcadia, CA 91007
Dan H. Lu President
SHINNING EDEN INVESTMENT INC
939 S Atlantic Blvd SUITE 215, Monterey Park, CA 91754
Dan Lu President
CHOW & LU FAMILY ENTERPRISES, INC
2532 Palomino Dr, Covina, CA 91724
Dan Lu Family Practitioner
Doctors Immedicare Doctor · Surgeons · Family Doctor
199 Hempstead Tpke, Hempstead, NY 11552 (516)5654110
Dan Dan Lu President
BEST CARE HOME HEALTH CARE, INC
18173 S Pioneer Blvd #O, Rancho Cucamonga, CA 91701 18173 Pioneer Blvd, Artesia, CA 90701
Dan Dan Lu President
LUCKY MARKETING & MANAGEMENT CORP
2144 S Hacienda Blvd, Hacienda Heights, CA 91745 2144 S Hacienda Blvd, Whittier, CA 91745
Dan H. Lu President
K & L ACCOUNTANCY CORP
939 S Atlantic Blvd STE 215, Monterey Park, CA 91754
Medicine Doctors
Dr. Dan Lu, West Hempstead NY - MD (Doctor of Medicine)
Doctors Premiere Care 199 Hempstead Tpke, West Hempstead, NY 11552 (516)5654110 (Phone)
Languages:
English Chinese
Hospitals:
Doctors Premiere Care 199 Hempstead Tpke, West Hempstead, NY 11552
Franklin Hospital 900 Franklin Avenue, Valley Stream, NY 11580
Long Island Jewish Medical Center 270 05 76Th Avenue, New Hyde Park, NY 11040
Mercy Medical Center 1000 North Village Avenue, Rockville Centre, NY 11570
Education:
Medical School Suzhou Medical College Graduated: 1984 Medical School Bronx Vamc Graduated: 1996 Medical School Bronx Vamc Graduated: 1997 Medical School Winthrop Hospital Graduated: 1998 Medical School Winthrop Hospital Graduated: 1999
Dr. Lu graduated from the Suzhou Med Coll, Suzhou City, Jiangsu, China in 1984. She works in West Hempstead, NY and specializes in Internal Medicine. Dr. Lu is affiliated with Long Island Jewish Valley Stream.