Daniel L Pevear

US Patent:

6541472, Apr 1, 2003

Filed:

Apr 12, 2000

Appl. No.:

09/547607

Inventors:

Daniel C. Pevear - Harleysville PA
Theodore J. Nitz - Pottstown PA
Martin Seipel - Malvern PA

Assignee:

ViroPharma Incorporated - Exton PA

International Classification:

C07D48704

US Classification:

514243, 51421705, 544184, 540599

Abstract:

Triazinoindole derivatives are useful in the prophylaxis and treatment of pestivirus infections and diseases associated with pestivirus infections.

US Patent:

20020081574, Jun 27, 2002

Filed:

Dec 7, 2001

Appl. No.:

10/010860

Inventors:

Marc Collett - Collegeville PA, US
Daniel Pevear - Harleysville PA, US
James Groarke - Phoenixville PA, US
Dorothy Young - Collegeville PA, US

International Classification:

C12Q001/70
C12N009/22
C12N015/86
C12P021/02

US Classification:

435/005000, 435/069100, 435/199000, 435/456000

Abstract:

Assay methods are disclosed having utility in the identification of therapeutic agents effective against human hepatitis C virus and related viruses. NS3 protein derived from these viruses, representing a native and authentic version of the complete protein sequence, is used in the assay methods of the invention, which enables identification and development of anti-viral agents exhibiting inhibition of the protein's NTPase and RNA helicase activities.

US Patent:

20030176431, Sep 18, 2003

Filed:

Feb 5, 2003

Appl. No.:

10/359400

Inventors:

Daniel Pevear - Harleysville PA, US
Theodore Nitz - Pottstown PA, US
Martin Seipel - Malvern PA, US

International Classification:

A61K031/5377
A61K031/55
A61K031/53
C07D487/02

US Classification:

514/232800, 514/243000, 544/112000, 544/184000, 514/217050, 540/599000

Abstract:

Triazinoindole derivatives are useful in the prophylaxis and treatment of pestivirus infections and diseases associated with pestivirus infections.

US Patent:

20040076949, Apr 22, 2004

Filed:

Oct 10, 2003

Appl. No.:

10/684025

Inventors:

Marc Collett - Collegeville PA, US
Daniel Pevear - Harleysville PA, US
James Groarke - Phoenixville PA, US
Dorothy Young - Collegeville PA, US

International Classification:

C12Q001/70
C07H021/04
C12N009/22
C12N015/86

US Classification:

435/005000, 435/069100, 435/456000, 435/199000, 435/320100, 435/325000, 536/023200

Abstract:

Assay methods are disclosed having utility in the identification of therapeutic agents effective against human hepatitis C virus and related viruses. NS3 protein derived from these viruses, representing a native and authentic version of the complete protein sequence, is used in the assay methods of the invention, which enables identification and development of anti-viral agents exhibiting inhibition of the protein's NTPase and RNA helicase activities.

US Patent:

20040127499, Jul 1, 2004

Filed:

Dec 15, 2003

Appl. No.:

10/736353

Inventors:

Daniel Pevear - Harleysville PA, US
Theodore Nitz - Pottstown PA, US
Martin Seipel - Malvern PA, US

International Classification:

A61K031/53
C07D487/02

US Classification:

514/243000, 544/184000

Abstract:

Triazinoindole derivatives are useful in the prophylaxis and treatment of pestivirus infections and diseases associated with pestivirus infections.

US Patent:

20060167109, Jul 27, 2006

Filed:

Feb 14, 2003

Appl. No.:

10/504206

Inventors:

Daniel Pevear - Harleysville PA, US
Gerald Rhodes - Los Altos CA, US
Theodore Nitz - Pottstown PA, US
Mark McKinlay - Phoenixville PA, US
Marc Collett - Washington DC, US

International Classification:

A61K 31/137

US Classification:

514649000

Abstract:

The present invention relates to the use of pleconaril to reduce the contagion of rhinovirus virions shed from a host infected with a rhinovirus and thereby reduce disease transmission or re-infection.

US Patent:

20100292185, Nov 18, 2010

Filed:

May 10, 2010

Appl. No.:

12/776745

Inventors:

Christopher J. Burns - Malvern PA, US
Rajesh Goswami - Secane PA, US
Randy W. Jackson - Glenmore PA, US
Thomas Lessen - Langhorne PA, US
Weiping Li - Norristown PA, US
Daniel Pevear - Downingtown PA, US
Pavan Kumar Tirunahari - Exton PA, US
Hongyu Xu - Phoenixville PA, US

International Classification:

A61K 31/69
C07F 5/02
A61P 31/00

US Classification:

514 64, 562 7, 544 69, 544229, 546 13, 548110

Abstract:

Disclosed herein are α-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising α-aminoboronic acids and methods of use thereof.

US Patent:

20110305666, Dec 15, 2011

Filed:

Aug 23, 2011

Appl. No.:

13/216106

Inventors:

David J. Rys - Philadelphia PA, US
Theodore J. Nitz - Pottstown PA, US
Janet A. Gaboury - Blue Bell PA, US
Christopher J. Burns - Malvern PA, US
Daniel C. Pevear - Harleysville PA, US
Thomas A. Lessen - Langhorne PA, US
Torsten Herbertz - Honey Brook PA, US

International Classification:

A61K 31/41
A61P 37/02
A61K 39/395
A61P 31/14
A61K 38/21
A61K 31/7056

US Classification:

424 854, 514381, 514 43, 4241301

Abstract:

Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.