Daniel Charles Ryan

US Patent:

20230035029, Feb 2, 2023

Filed:

Jul 29, 2021

Appl. No.:

17/389005

Inventors:

- San Diego CA, US
Xiaoqiang ZENG - San Diego CA, US
Michael D. FOX - San Diego CA, US
Branden R. ELAM - Oroville CA, US
Daniel RYAN - La Mesa CA, US

Assignee:

Solar Turbines Incorporated - San Diego CA

International Classification:

F01D 25/12

Abstract:

A tip shroud, comprising a plurality of tip shoes encircling a rotor assembly, in a turbine may deform due to thermal gradients experienced during operation of the turbine. Accordingly, a tip shoe is disclosed that utilizes an internal cooling cavity to supply coolant throughout the interior of the tip shoe, as well as to the slash faces of the tip shoe. In addition, features are described that increase the surface area exposed to the coolant, while remaining suitable for additive manufacturing.

US Patent:

20210138117, May 13, 2021

Filed:

Dec 29, 2020

Appl. No.:

17/136830

Inventors:

- San Diego CA, US
Daniel R. Ryan - San Diego CA, US
Sigeng Chen - San Diego CA, US

Assignee:

Human BioMolecular Research Institute - San Diego CA

International Classification:

A61L 27/38
A61L 27/12
C07D 215/44
C07D 487/04
A61K 31/519
A61K 33/42
A61K 38/18
A61K 31/4706
A61K 31/12
A61K 45/06
A61K 35/28
G01N 33/50
A61L 27/28
A61L 27/32
A61L 27/42
A61L 27/54
A61L 27/58
C07C 49/248
C07C 49/255
C07C 225/22
C07C 229/40
C12Q 1/6883

Abstract:

Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, trans-differentiation, and proliferation of animal cells into the osteoblast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.

US Patent:

20160038641, Feb 11, 2016

Filed:

Mar 17, 2014

Appl. No.:

14/776995

Inventors:

- San Diego CA, US
Daniel R. RYAN - San Diego CA, US
Sigeng CHEN - San Diego CA, US

Assignee:

HUMAN BIOMOLECULAR RESEARCH INSTITUTE - San Diego CA

International Classification:

A61L 27/38
A61L 27/54
A61L 27/12
A61L 27/42
C07D 215/44
A61L 27/32
A61L 27/28
C07D 487/04
C07C 49/255
C07C 225/22
C07C 49/248
C07C 229/40
G01N 33/50
C12Q 1/68
A61L 27/58

Abstract:

Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, transdifferentiation, and proliferation of animal cells into the osteoblast blast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of Formula II, IV, and VI independently or preferably in combination with a matrix to afford bone cells. Small molecule-stimulated cells were also combined with a matrix, placed with a cellular adhesive or material carrier and implanted to a site in an animal for bone repair. Matrix pretreated with compounds of Formula II, IV, and VI were also used to cause cells to migrate to the matrix that is of use for therapeutic purposes.

Address:

3945 Tartan Trl, Virginia Bch, VA 23456

VIN:

YV4CZ982171345424

Make:

VOLVO

Model:

XC90

Year:

2007