David James Goldman

US Patent:

6762294, Jul 13, 2004

Filed:

Aug 15, 2001

Appl. No.:

09/930589

Inventors:

David Goldman - Potomac MD
Nakao Iwata - Aichi, JP
Marc A. Schuckit - Del Mar CA

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07H 2104

US Classification:

536 235, 435 6

Abstract:

Compositions and methods based on a polymorphism in the gene encoding the 6 subunit of the human GABA neurotransmitter receptor are disclosed. This polymorphism results in the substitution of a serine residue for a proline residue ordinarily present at amino acid position 385 of the 6 polypeptide sequence. Significantly, the polymorphism was associated with decreased sensitivity to ethanol and benzodiazepine drugs.

US Patent:

7273699, Sep 25, 2007

Filed:

Jul 25, 2002

Appl. No.:

10/206561

Inventors:

Robert H. Lipsky - Kensington MD, US
Chiara Mazzanti - Washington DC, US
David Goldman - Potomac MD, US

Assignee:

The United States of America as Represented by the Secretary of the Department of Health and Human Services - Washington DC

International Classification:

C12Q 1/68
C12P 19/34

US Classification:

435 6, 435 912

Abstract:

Sequence variations, such as polymorphisms, are detected by detecting differences between or among melting profiles of plural nucleic acids. Melting profiles are produced by observing the nucleic acids during a temperature change over a period of time. If the nucleic acids are diluted into solutions for analysis, the nucleic acid concentrations between or among the solutions can be substantially the same. The melting profiles and sequence variation can be used to identify changes in a wild-type nucleic acid sequence, such as a single-nucleotide polymorphism (SNP), a small insertion or deletion, or a small inversion.

US Patent:

45088209, Apr 2, 1985

Filed:

Feb 27, 1984

Appl. No.:

6/582862

Inventors:

Carl R. Merril - Rockville MD
David Goldman - Gaithersburg MD

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C12Q 129
C12Q 116
G01T 100

US Classification:

435 29

Abstract:

The invention provides an assay method for cellular and extracellular protein biodynamics comprising the use of radiochemical techniques in combination with high resolution protein separation procedures and recently developed silver stain techniques, to assess turnover of polypeptides over time. Quenching of polypeptide radiolables in silver stained gels is obviated by the use of. sup. 14 C-labelled amino acids as precursors.

US Patent:

55893317, Dec 31, 1996

Filed:

Sep 22, 1993

Appl. No.:

8/125628

Inventors:

David A. Nielsen - Kensington MD
David Goldman - Potomac MD
Markku Linnoila - Bethesda MD
Matti Virkkunen - Helsinki, FI

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C12Q 168
C07H 2104
C12P 1934

US Classification:

435 6

Abstract:

A method of detecting abnormal serotonergic function in an impulsive human subject is disclosed. The method comprises detecting an L allele of a gene encoding tryptophan hydroxylase. The invention also includes an isolated nucleic acid having a sequence specific to an L allele of a gene encoding tryptophan hydroxylase. The nucleic acid may migrate in a denaturing gel at the same rate as a second nucleic acid specific to a corresponding region of a U allele of a gene encoding tryptophan hydroxylase, and migrate in a nondenaturing gel at a rate about 1. 02 times the migration rate of the second nucleic acid.

US Patent:

56541392, Aug 5, 1997

Filed:

Sep 21, 1994

Appl. No.:

8/310271

Inventors:

Jaakko Lappalainen - Bethesda MD
Markku Linnoila - Bethesda MD
David Goldman - Potomac MD

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C12N 1500
C12N 1512

US Classification:

435 6

Abstract:

We describe identification of a non-conservative amino acid substitution in the 5-HT. sub. 2C receptor gene. The variant was found using single strand conformational polymorphism (SSCP) analysis. By typing this polymorphism in CEPH families, the gene was genetically mapped on the long arm of the X chromosome. Since this polymorphism was not detectable as a conventional RFLP, we also developed a PCR-RFLP based method which allows rapid genotyping in populations and families.

US Patent:

57631832, Jun 9, 1998

Filed:

Nov 8, 1996

Appl. No.:

8/745269

Inventors:

Ullamari Pesonen - Turku, FI
Markku Koulu - Turku, FI
Markku Linnoila - Bethesda MD
David Goldman - Potomac MD
Matti Virkkunen - Helsinki, FI

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C12Q 168
C12P 1934
C07H 2102
C07H 2104

US Classification:

435 6

Abstract:

An allelic variant of the 5HT7 serotonin receptor was discovered. Family study data indicate that this variant can be correlated to alchoholic offerders. DNA encoding the variant protein, the protein itself, vectors containing the variant gene and cell lines carrying a vector with the variant gene are part of the invention.