David L Goldsmith

US Patent:

20100286791, Nov 11, 2010

Filed:

Nov 19, 2007

Appl. No.:

11/986021

Inventors:

David S. Goldsmith - Atlanta GA, US

International Classification:

A61F 2/04
A61M 36/12
A61M 25/00
A61M 31/00
A61B 18/04
A61B 17/50
A61B 17/28
A61F 13/00

US Classification:

623 237, 600 8, 604523, 604 9301, 606 27, 604524, 606211, 606205, 602 43

Abstract:

Provided are methods and apparatus for the use of magnetic traction to maintain the patency of a tubular anatomical structure, whether a vessel, duct, the trachea, bronchus, bile duct, ureter, vas deferens, fallopian tube, or portions of the digestive tract, as to constitute means for extraluminal stenting. An extraluminal stent consists of a perimedial or medial intravascular and an extravascular component. The intravascular component consists of ferromagnetic spherules implanted aeroballistically or stays implanted by means of a special hand tool, while the extravascular component consists of a pliant jacket or mantle that has magnets mounted about its outer surface. A catheter adapted for use as the barrel of a gas-operated implant insertion gun is so devised that it can be used independently to perform an angioplasty and thereafter have its free or extracorporeal end inserted into the airgun to initiate implantation of the intravascular component without the need for withdrawal and reinsertion through the introducer sheath. When the implants must be spaced too closely together to be controlled by hand, a positional control system is used to effect discharge automatically. Spherules that consist entirely of medication or that have a radiation emitting seed as the core can be implanted with the same apparatus. A glossary of terms follows the specification.

US Patent:

20220362534, Nov 17, 2022

Filed:

Jul 14, 2022

Appl. No.:

17/865025

Inventors:

David S. Goldsmith - Atlanta GA, US

International Classification:

A61M 37/00
A61K 9/16

Abstract:

Described are surgical tools to facilitate the proper implantation beneath the outer layer of tubular anatomical structures, or ductus, to include vessels, the trachea, esophagus, gut, and ureters, as well as the outer layer or within the parenchyma of organs, glands, or other tissue, of medicinal, magnetically susceptible, magnetized, and/or radiation-emitting spherules sized in proportion to the substrate structure. Spherule insertion tools expedite insertion transluminally to implant the wall surrounding a lumen making possible therapy and/or extraluminal stenting which leaves the lumen clear for subsequent passage. Spherules can also be introduced into deeper tissue through a ‘keyhole’ incision at the body surface. For evolving methods calling for the placement of numerous ‘seeds’ and/or boluses, eliminated are the need for more extensive incision with increased trauma, procedural duration, and healing time. Avoidance of the lumen is augmented by placing the magnets subcutaneously rather than using a magnetized perivascular collar, or stent-jacket.

US Patent:

20220273312, Sep 1, 2022

Filed:

Aug 11, 2020

Appl. No.:

16/873914

Inventors:

David S. Goldsmith - Atlanta GA, US

International Classification:

A61B 17/122
A61F 2/24

Abstract:

Set forth are the structure, function, placement, and applications of vascular valves and servovalves. In the vascular tree, the diversion, shunting, and bypass of flow these provide allow solid organ transplantation which eliminates anoxia and graft organ degradation following harvesting and storage, likely including late term cardiac allograft vasculopathy. Along the lower urinary tract, the diversion of urine from damaged ureters to the native or an artificial bladder or collection bag alleviates problems of intractable urinary incontinence, nocturia, overactive bladder, and frequent urination. Where the lower tract is missing, the synthetics in a valve-based prosthesis preclude infection and degenerative metaplastic transition which can result in malignancy when gut is used to construct a neobladder and/or high maintenance stoma. Accessory channels in side-entry valves and servovalves allow the direct pipe-targeting of medication to sites of disease, anastomoses, or any other trouble spots.

US Patent:

20220184311, Jun 16, 2022

Filed:

Mar 8, 2022

Appl. No.:

17/689880

Inventors:

David S. Goldsmith - Atlanta GA, US

International Classification:

A61M 5/172
A61M 5/14
A61M 5/142
A61M 39/02
G16H 20/17
G16H 20/30
G16H 40/63

Abstract:

A fully implanted automatic disorder response system acts as a backup “immune” system, immediately detecting and dispensing an enzyme deficient or lacking due to an inborn error of metabolism, for example, in accordance with its prescription-program. In response to a disease, the remedial action is usually medicinal and/or electrostimulatory. By directly pipeline-targeting agents through pipelines from implanted reservoirs to leak-free and durable tissue connectors at the focal points of chronic disease, the system avoids the dispersion of drugs throughout the circulation and the side effects this causes, fundamentally liberalizing while optimizing the use of drugs. Electrostimulatory and other end-effectors available, each morbidity or site thereof in comorbid disease is assigned to an arm or channel of an hierarchical control system. Symptom sensors pass data up through successively higher-level microcontroller nodes to generate the cross-channel, cross-morbidity view the control microprocessor uses to command the remedial action that will optimize overall homeostasis.

US Patent:

20210145445, May 20, 2021

Filed:

Feb 14, 2018

Appl. No.:

15/932172

Inventors:

David S. Goldsmith - Atlanta GA, US

International Classification:

A61B 17/12
A61F 2/82
A61B 17/34
A61B 17/00
A61B 18/18

Abstract:

Described are coordinated apparatus and methods for drug targeting, clearing the lumen, placing implants within the wall of, and stenting, as necessary, any tubular anatomical structure with single luminal entry. Miniature balls, or miniballs, are introduced into the wall aeroballistically from within the lumen, or small arcuate bands called stays inserted through the outer tunic by means of a hand tool. When miniballs must be placed too closely together to be controlled by hand, a positional control system assists in discharge. Implantation within or proximal to diseased tissue targeting, and thus concentrating the medication in that tissue, miniballs and stays can be used to deliver and controllably release multiple drugs, a radionuclide, or an open or closed loop smart-pill, for example. A glossary of terms follows the specification. Balance of abstract appended to the section entitled Summary of the Invention.

US Patent:

20190374213, Dec 12, 2019

Filed:

Jun 8, 2018

Appl. No.:

15/998002

Inventors:

David S. Goldsmith - Atlanta GA, US

International Classification:

A61B 17/02
A61B 10/02
A61M 5/14
A61N 5/10
A61M 5/142
A61M 5/172
A61M 3/02
A61M 39/24
A61M 27/00
A61B 1/32
A61B 17/3207
A61M 1/36
A61F 2/04
A61M 5/168

Abstract:

Described are means for the direct and continuous connection of a catheter to the lumen of any tubular anatomical structure, or ductus, without medically significant leakage. A port implanted at the body surface with piping to a periductal collar allows drug or radionuclide delivery that bypasses the upstream lumen. The port allows injection, infusion, aspiration, or attachment of an automatic ambulatory pump. A superparamagnetic nanoparticle carrier-bound drug, for example, can be introduced into the lumen to pass downstream until the particles, with or without the drug still bound, are drawn into the lumen wall by a magnetized jacket surrounding the ductus. Such constitutes a method of drug targeting whereby a segment of a vessel or the territory supplied by a branch of that segment can be circumscribed for exposure to the drug. A jacket with side-entry connector positioned in surrounding relation to a lesion requiring treatment can itself be magnetized.

US Patent:

20140163664, Jun 12, 2014

Filed:

Jan 9, 2013

Appl. No.:

13/694835

Inventors:

David S. Goldsmith - Atlanta GA, US

International Classification:

A61F 2/82
A61M 37/00
A61F 2/95

US Classification:

623 111, 623 237, 604500, 604 9301

Abstract:

Described are coordinated apparatus and methods for drug targeting, clearing the lumen, placing implants within the wall of, and stenting, as necessary, any tubular anatomical structure with single luminal entry. Miniature balls, or miniballs, are introduced into the wall aeroballistically from within the lumen, or small arcuate bands called stays inserted through the outer tunic by means of a hand tool. When miniballs must be placed too closely together to be controlled by hand, a positional control system assists in discharge. Implantation within or proximal to diseased tissue targeting, and thus concentrating the medication in that tissue, miniballs and stays can be used to deliver and controllably release multiple drugs, a radionuclide, or an open or closed loop smart-pill, for example. A glossary of terms follows the specification. Balance of abstract appended to paragraph [