David Eugene Goldsmith

US Patent:

6462075, Oct 8, 2002

Filed:

Dec 26, 2000

Appl. No.:

09/748599

Inventors:

J. Phillip Bowen - Hull GA
Thomas Phillip Robinson - Durham NC
Tedman Ehlers - Athens GA
David Goldsmith - Atlanta GA
Jack Arbiser - Atlanta GA

Assignee:

The University of Georgia Research Foundation, Inc. - Athens GA
Emory University - Atlanta GA

International Classification:

C07D31100

US Classification:

514460, 514685, 514729, 549401, 568326, 568334

Abstract:

The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, incluidng angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.

US Patent:

6906105, Jun 14, 2005

Filed:

Jul 18, 2002

Appl. No.:

10/198786

Inventors:

J. Phillip Bowen - Hull GA, US
Thomas Philip Robinson - Durham NC, US
Tedman Ehlers - Athens GA, US
David Goldsmith - Atlanta GA, US
Jack Arbiser - Atlanta GA, US

International Classification:

A61K031/12
C07C049/213

US Classification:

514679, 568325

Abstract:

The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.

US Patent:

7432303, Oct 7, 2008

Filed:

Mar 8, 2005

Appl. No.:

11/074545

Inventors:

J. Phillip Bowen - Hull GA, US
Thomas Philip Robinson - Durham NC, US
Tedman Ehlers - Athens GA, US
David Goldsmith - Atlanta GA, US
Jack Arbiser - Atlanta GA, US

Assignee:

James and Emory University - Atlanta GA

International Classification:

C07C 49/11
C07C 49/115
A61K 31/12

US Classification:

514679, 514680, 568325, 568326

Abstract:

The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.

US Patent:

7872029, Jan 18, 2011

Filed:

Aug 22, 2008

Appl. No.:

12/229340

Inventors:

J. Phillip Bowen - Hull GA, US
Thomas Philip Robinson - Durham NC, US
Tedman Ehlers - Athens GA, US
David Goldsmith - Atlanta GA, US
Jack Arbiser - Atlanta GA, US

International Classification:

C07D 213/02
A61K 31/44

US Classification:

514332, 514354, 514685, 546262, 546340, 568334

Abstract:

The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiogenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.