David Brent Rawlins

US Patent:

6407124, Jun 18, 2002

Filed:

Jun 10, 1999

Appl. No.:

09/329616

Inventors:

David B. Rawlins - Morrisville PA
S. David Kimball - E. Windsor NJ
Kyoung S. Kim - North Brunswick NJ
Raj N. Misra - Hopewell NJ
Kevin R. Webster - Yardley PA

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 314439

US Classification:

514342, 514371, 5462707, 548195

Abstract:

Compounds of the formula and pharmaceutically acceptable salts thereof are provided.

US Patent:

6521759, Feb 18, 2003

Filed:

Apr 20, 2001

Appl. No.:

09/839751

Inventors:

Kyoung S. Kim - North Brunswick NJ
S. David Kimball - East Windsor NJ
David B. Rawlins - Morrisville PA
Raj N. Misra - Hopewell NJ
Michael A. Poss - Lawrenceville NJ
Kevin R. Webster - Yardley PA
John T. Hunt - Princeton NJ
Wen-Ching Han - Newtown PA

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

C07D41712

US Classification:

548184

Abstract:

The present invention describes compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R , R , R , R , R , m and n are as defined in the specification. The compounds of formula I are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimers disease, chemotherapy-induced alopecia, and cardiovascular disease.

US Patent:

6617446, Sep 9, 2003

Filed:

Jun 3, 1999

Appl. No.:

09/325062

Inventors:

Andreas L. Papadopoulos - Plainsboro NJ
Douglas J. Hanchett - Wharton NJ
Peter T. Trzasko - Plainsboro NJ
David C. Rawlins - Piscataway NJ
Vincent R. Green - North Plainfield NJ
Paul A. Altieri - Belle Mead NJ

Assignee:

National Starch and Chemical Investment Holding Corporation - New Castle DE

International Classification:

C08B 3100

US Classification:

536102, 514 60

Abstract:

The present invention is directed to cold water swellable starches exhibiting delayed viscosity development, preparation and use thereof. The cold water swellable starches are prepared using methods known in the art and then are compacted. These starches provide all the advantages of CWS starch, including texture, heavy body, glossy sheen, and viscosity. However, the rate of hydration may be controlled to delay viscosity development. Such starches may be used for a variety of industrial applications including food products, personal care products, cleansers, liquid detergents and fabric softeners, oil-well drilling, and paints and allow for easier processing of such products.

US Patent:

6649606, Nov 18, 2003

Filed:

Nov 7, 2002

Appl. No.:

10/289671

Inventors:

Mark Alden Hermsmeier - Somerville NJ
David B. Rawlins - Morrisville PA
John Wityak - Robbinsville NJ

Assignee:

Bristol-Myers Squibb Co. - Princeton NJ

International Classification:

C07D20902

US Classification:

51421701, 514307, 514412, 540594, 546139, 548492

Abstract:

Tetrahydroisoquinoline analogs are provided which are modulators of chemokine receptor activity. The tetrahdroisoquinoline analogs thereof have the structure wherein R , R , R , R , X , X , X , X , m, n and p are as described herein.

US Patent:

6720347, Apr 13, 2004

Filed:

Mar 29, 2002

Appl. No.:

10/112133

Inventors:

David B. Rawlins - Morrisville PA
S. David Kimball - E. Windsor NJ
Kyoung S. Kim - North Brunswick NJ
Raj N. Misra - Hopewell NJ
Kevin R. Webster - Yardley PA

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31426

US Classification:

514371, 5462707, 548195, 514342

Abstract:

Compounds of the formula and pharmaceutically acceptable salts thereof, wherein R and A are defined herein, are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimers disease and cardiovascular disease.

US Patent:

6809102, Oct 26, 2004

Filed:

Mar 22, 2002

Appl. No.:

10/104257

Inventors:

Spencer David Kimball - East Windsor NJ
Louis J. Lombardo - Belle Mead NJ
David B. Rawlins - Morrisville PA
Robert J. Schmidt - Hainesport NJ
David K. Williams - Delran NJ

Assignee:

Bristol-Myers Squibb Company - Princeton NJ

International Classification:

A61K 31513

US Classification:

514256, 514274, 544316, 544323, 544324

Abstract:

The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds induce mitotic arrest thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inducing mitotic arrest.

US Patent:

7423043, Sep 9, 2008

Filed:

Feb 15, 2006

Appl. No.:

11/354636

Inventors:

David Brent Rawlins - Morrisville PA, US
Michael Victor Voronkov - Pennington NJ, US
Yulian Zhang - Yardley PA, US

Assignee:

Lexicon Pharmaceuticals, Inc. - The Woodlands TX

International Classification:

C07D 487/04
A61K 31/519
A61P 35/04

US Classification:

5142651, 544280

Abstract:

Substituted 4-piperidin-1-yl-7H-pyrrolo[2,3-D]pyrimidine compounds are disclosed, as well as compositions comprising them and methods of their use for the treatment, prevention and management of various diseases and disorders.

US Patent:

7781577, Aug 24, 2010

Filed:

Sep 27, 2007

Appl. No.:

11/862690

Inventors:

Bryce Alden Harrison - Hamilton NJ, US
Spencer David Kimball - East Windsor NJ, US
Ross Mabon - Princeton NJ, US
David Brent Rawlins - Morrisville PA, US
Nicole C Goodwin - Pennington NJ, US

Assignee:

Lexicon Pharmaceuticals, Inc. - The Woodlands TX

International Classification:

A61K 31/7008
A61K 31/7034
A61K 31/7042
C07H 5/06
C07H 5/10
C07H 7/04
C07H 7/06

US Classification:

536 291, 514 23, 514 34, 514 25, 514 42, 536 53

Abstract:

Compounds and pharmaceutical compositions comprising them are disclosed that may be useful for the treatment of diseases and disorders such as diabetes and obesity.