David G Richard

US Patent:

20120134959, May 31, 2012

Filed:

Apr 15, 2010

Appl. No.:

13/264776

Inventors:

Kevin Joseph Curran - Somerville MA, US
Joshua Aaron Kaplan - Seattle WA, US
David James Richard - Littleton MA, US
Jeroen Cunera Verheijen - Westborough MA, US
Arie Zask - New York NY, US

Assignee:

Wyeth LLC - Madison NJ

International Classification:

A61K 31/5383
A61K 31/655
A61K 31/7068
A61K 31/675
A61P 35/00
A61K 31/7048
A61K 38/50
A61K 39/395
A61K 38/21
C07D 498/08
A61K 33/24

US Classification:

424 856, 544105, 544 74, 5142305, 514151, 514 49, 514110, 424649, 514 27, 424 946, 4241331

Abstract:

The invention relates to pyrimidine compounds of the Formula I: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.

US Patent:

55964869, Jan 21, 1997

Filed:

Oct 5, 1994

Appl. No.:

8/318507

Inventors:

Paul R. Young - Cromwell CT
David W. Richard - Southington CT
Leonard Bazar - Middletown CT

Assignee:

Kaman Aerospace Corporation - Bloomfield CT

International Classification:

H05K 118
H05K 506
H01R 1358
H01R 2370

US Classification:

361737

Abstract:

An improved PC Card element, particularly a PC card unit, is presented in which the unit is hermetically sealed. The unit has a metallic frame, a metallic header with glass or ceramic encapsulated through pins, and opposed outer metallic covers, all of the metallic elements being welded together to form a hermetically sealed unit. The metallic frame and header is preferably formed as a single piece, i. e. , unitary part, either by casting and machining or by metal injection molding.

US Patent:

48707031, Sep 26, 1989

Filed:

Oct 12, 1988

Appl. No.:

7/257186

Inventors:

James A. Augeri - Middletown CT
Paul R. Young - Cromwell CT
David W. Richard - Meriden CT
David Johnson - Portland CT

Assignee:

Raymond Engineering Inc. - Middletown CT

International Classification:

G11B 1702
G11B 2108
G11B 2112

US Classification:

360 9807

Abstract:

A magnetic disc memory unit is presented wherein a pair of read/write heads are on a pivot arm which is belt driven by a stepper motor. The read/write heads move in an arc, and they retract to a landing position fully off the disc when the unit is shut down. The unit incorporates several features to overcome or minimize vibration and temperature problems so that the unit is suitable for operation in extreme vibration and temperature environments and in all attitudes. These features include, but are not limited to, a rotary table and a rotary mounted spindle made from different materials and joined by a cryogenic joint; pre-loaded elastomeric "O" rings; an electrically conductive ball used for grounding the disc support to the housing; and a single continuous split belt connected between the output of the stepper motor and the pivot arm.

US Patent:

54576067, Oct 10, 1995

Filed:

Dec 23, 1993

Appl. No.:

8/178385

Inventors:

Paul R. Young - Cromwell CT
Robert Blake - Middletown CT
Christopher Staehly - East Haddam CT
David Richard - Southington CT
Leonard Bazar - Middletown CT

Assignee:

Raymond Engineering Inc. - Middletown CT

International Classification:

H05K 118
H05K 506
H01R 1358
H01R 2370

US Classification:

361737

Abstract:

An improved PC Card element, particularly a flash card unit, is presented in which the unit is hermetically sealed. The unit has a metallic frame, a metallic header with glass or ceramic encapsulated through pins, and opposed outer metallic covers, all of the metallic elements being of the same metal and being welded together to form a hermetically sealed unit.

US Patent:

49656864, Oct 23, 1990

Filed:

Mar 31, 1989

Appl. No.:

7/331462

Inventors:

Paul R. Young - Cromwell CT
David W. Richard - Meriden CT
Arthur J. Treff - East Hartford CT
Christopher E. Staehly - East Haddam CT

Assignee:

Raymond Engineering Inc. - Middletown CT

International Classification:

G11B 1708

US Classification:

360 9807

Abstract:

A disc drive assembly for a magnetic disc memory unit is presented. The disc drive assembly has a stationary spindle to which a motor stator assembly is fastened by a wedge ring structure. The motor rotor assembly is constituted by a rotary hub mounted around the stator, the hub having a motor magnet mounted therein. A plurality of magnetic discs may be mounted on the exterior of the hub.

US Patent:

20220378756, Dec 1, 2022

Filed:

Sep 18, 2020

Appl. No.:

17/761795

Inventors:

- Watertown MA, US
Sanjeev Forsyth - Milton MA, US
Neal Green - Newton MA, US
Gary Gustafson - Ridgefield CT, US
Patrick F. Kelly - Concord MA, US
Gary Marshall - Watertown MA, US
Lorna Mitchell - Cambridge, NZ
Madhu Mondal - Winchester MA, US
Maria Ribadeneira - Cambridge MA, US
David Richard - Littleton MA, US
Patricia Schroeder - Watertown MA, US
Zhongguo Wang - Lexington MA, US

International Classification:

A61K 31/436
A61K 9/48
A61K 9/00
A61P 7/06

Abstract:

The compound (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrroll-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one, or a pharmaceutically acceptable salt thereof, is useful to increase the affinity of hemoglobin for oxygen. Methods and compositions for the treatment of a hemoglobinopathies are provided herein, including certain pharmaceutical compositions for activating PKR.

US Patent:

20220304987, Sep 29, 2022

Filed:

Mar 18, 2022

Appl. No.:

17/698505

Inventors:

- Watertown MA, US
Neal Green - Newton MA, US
Gary Gustafson - Ridgefield CT, US
Gary Marshall - Watertown MA, US
Lorna Mitchell - Cambridge, NZ
David Richard - Littleton MA, US
Zhongguo Wang - Lexington MA, US
Sanjeev Forsyth - Milton MA, US
Patrick F. Kelly - Concord MA, US
Madhu Mondal - Winchester MA, US
Maria Ribadeneira - Cambridge MA, US
Patricia Schroeder - Somerville MA, US

International Classification:

A61K 31/436
A61P 9/00

Abstract:

The compound (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one, or a pharmaceutically acceptable salt thereof, is useful to increase the affinity of hemoglobin for oxygen. Methods and compositions for the treatment of a hemoglobinopathies are provided herein, including certain pharmaceutical compositions for activating PKR.

US Patent:

20220185806, Jun 16, 2022

Filed:

Dec 21, 2021

Appl. No.:

17/557215

Inventors:

- Watertown MA, US
Bingsong Han - Westwood MA, US
Cuixian Liu - Madison CT, US
Stephanos Ioannidis - Natick MA, US
Alexandre Joseph Buckmelter - Acton MA, US
David James Richard - Littleton MA, US
Matthew W. Martin - Arlington MA, US
Steven Mischke - Waltham MA, US
Scot Mente - Watertown MA, US

International Classification:

C07D 417/12
C07C 261/04
C07D 231/40
C07D 241/04
C07D 265/30
C07D 277/46
C07D 277/56
C07D 417/04

Abstract:

The present disclosure relates to chemical entities useful as inhibitors of Ubiquitin Specific Peptidase 30 (USP30), pharmaceutical compositions comprising the chemical entities, and methods of using the chemical entities. The chemical entities as disclosed herein can be useful in the treatment of a disease, disorder, or condition involving mitochondrial dysfunction, including neurodegenerative diseases, motor neuron diseases, metabolic disorders, and cancers, among other ailments.