David Wei Tung

US Patent:

8153603, Apr 10, 2012

Filed:

Feb 24, 2006

Appl. No.:

11/816705

Inventors:

James G. Karras - San Marcos CA, US
Susan Gregory - San Diego CA, US
Jeffrey R. Crosby - Carlsbad CA, US
Mausumee Guha - La Costa CA, US
David Tung - Superior CO, US
Susan M. Freier - San Diego CA, US

Assignee:

Isis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 48/00
C07H 21/04

US Classification:

514 44, 536 231, 536 245

Abstract:

Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.

US Patent:

20080103106, May 1, 2008

Filed:

Oct 11, 2006

Appl. No.:

11/548661

Inventors:

James G. Karras - San Marcos CA, US
Susan Gregory - San Diego CA, US
David Tung - Wildwood MO, US
Jeffrey R. Crosby - Murrieta CA, US

Assignee:

Isis Pharmaceuticals, Inc. - Carlsbad CA

International Classification:

A61K 31/7088
A61P 11/00

US Classification:

514 44

Abstract:

Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.

US Patent:

20120316221, Dec 13, 2012

Filed:

Feb 29, 2012

Appl. No.:

13/408646

Inventors:

JAMES G. KARRAS - SAN MARCOS CA, US
SUSAN GREGORY - SAN DIEGO CA, US
JEFFREY R. CROSBY - CARLSBAD CA, US
MAUSUMEE GUHA - TRABUCO CANYON CA, US
DAVID TUNG - WILDWOOD MO, US
SUSAN M. FREIER - SAN DIEGO CA, US
KENNETH W. DOBIE - DEL MAR CA, US

Assignee:

ISIS PHARMACEUTICALS, INC. - CARLSBAD CA

International Classification:

C07H 21/04
A61P 29/00
A61P 11/00
A61K 31/7088

US Classification:

514 44 A, 536 245

Abstract:

Disclosed herein are compounds, compositions and methods for modulating the expression of IL-4R alpha in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of IL 4R-α, airway hyperresponsiveness, and/or pulmonary inflammation.

US Patent:

56204418, Apr 15, 1997

Filed:

Jun 15, 1994

Appl. No.:

8/260084

Inventors:

Richard J. Greff - Yorba Linda CA
David W. Tung - Yorba Linda CA

Assignee:

Stackhouse, Inc. - Riverside CA

International Classification:

A61B 1739

US Classification:

606 32

Abstract:

A combination of electrical surgical apparatus includes a first electrical surgical apparatus having a first operative state and a second operative state. A conductor for conducting electrical energy to the first apparatus has first characteristics when the first apparatus is in the first operative state and has second characteristics when the first apparatus is in the second operative state. A sensor is coupled between the first apparatus and a second electrical surgical apparatus having a first operative state and a second operative state. The sensor is responsive to a change from one of the first and second characteristics of the conductor to the other of the first and second characteristics of the conductor to produce a transition signal. A switch coupled between the sensor and the second apparatus is responsive to the transition signal to change the state of the second apparatus from one of the first and second operative states of the second apparatus to the other of the first and second operative states of the second apparatus.

US Patent:

58534105, Dec 29, 1998

Filed:

Apr 7, 1997

Appl. No.:

8/840730

Inventors:

Richard J. Greff - Yorba Linda CA
David W. Tung - Yorba Linda CA

Assignee:

Stackhouse, Inc. - Palm Springs CA

International Classification:

A61B 1736

US Classification:

606 32

Abstract:

A combination of electrical surgical apparatus includes a first electrical surgical apparatus having a first operative state and a second operative state. A conductor for conducting electrical energy to the first apparatus has first characteristics when the first apparatus is in the first operative state and has second characteristics when the first apparatus is in the second operative state. A sensor is coupled between the first apparatus and a second electrical surgical apparatus having a first operative state and a second operative state. The sensor is responsive to a change from one of the first and second characteristics of the conductor to the other of the first and second characteristics of the conductor to produce a transition signal. A switch coupled between the sensor and the second apparatus is responsive to the transition signal to change the state of the second apparatus from one of the first and second operative states of the second apparatus to the other of the first and second operative states of the second apparatus.