David E Walsh

US Patent:

6946554, Sep 20, 2005

Filed:

Jun 29, 2004

Appl. No.:

10/878035

Inventors:

Arthur J. Elliott - Aiken SC, US
David A. Walsh - Birmingham AL, US
Philip E. Morris - Birmingham AL, US

Assignee:

BioCryst Pharmaceuticals, Inc. - Birmingham AL

International Classification:

C07D487/04
C07D207/34

US Classification:

544280, 548532

Abstract:

Derivatives of 9-deazaguanine of the formula I: are prepared by reacting an aldehyde or ketone of the formula II: with a dialkylaminomalonate to produce an enamine. The enamine is then reacted with a base to produce a pyrrole represented by the formula: The pyrrole is reacted with a compound represented by the formula ROC(O)N═C(Z)NHC(O)ORor a derivative of carbamimidoic acid to provide a protected guanidine compound. The guanidine compound is converted to the desired deazaguanine by reaction with 1) trifluoracetic acid or 2) C-Calkoxide or alkali metal or alkaline earth metal hydroxide followed by neutralization with an acid.

US Patent:

7109361, Sep 19, 2006

Filed:

Oct 29, 2003

Appl. No.:

10/696730

Inventors:

Mark Hoffman - Lakeville MN, US
David Baugh - Plymouth MN, US
Michael Ahern - St. Paul MN, US
David Walsh - Hollywood SC, US

Assignee:

Nu-Tein Co., Inc. - St. Paul MN
AMEC E & C Services Inc - Decatur GA

International Classification:

C07C 1/00

US Classification:

554 8

Abstract:

The present invention provides a process for an industrial scale extraction and purification of xanthophylls (e. g. , lutein and zeaxanthin) from plant material (e. g. , alfalfa or other leafy green crops having high levels of chlorophyll). The process involves harvesting lutein rich alfalfa, extracting an oleoresin from the alfalfa leaves, saponifying the oleoresin, extracting and extracting lutein using a series of solvent extractions specific for oleoresin obtained from alfalfa or other leafy green plants.

US Patent:

7253294, Aug 7, 2007

Filed:

Aug 8, 2006

Appl. No.:

11/463193

Inventors:

Mark Hoffman - Lakeville MN, US
David Baugh - Plymouth MN, US
Michael Ahern - St. Paul MN, US
David Walsh - Hollywood SC, US

Assignee:

Nu-Tein Co., Inc. - St. Paul MN

International Classification:

C11B 1/00

US Classification:

554 8

Abstract:

The present invention provides a process for an industrial scale extraction and purification of xanthophylls (e. g. , lutein and zeaxanthin) from plant material (e. g. , alfalfa or other leafy green crops having high levels of chlorophyll). The process involves harvesting lutein rich alfalfa, extracting an oleoresin from the alfalfa leaves, saponifying the oleoresin, extracting and extracting lutein using a series of solvent extractions specific for oleoresin obtained from alfalfa or other leafy green plants.

US Patent:

20040176475, Sep 9, 2004

Filed:

Oct 17, 2003

Appl. No.:

10/688776

Inventors:

Mark Hoffman - Lakeville MN, US
David Baugh - Plymouth MN, US
Michael Ahern - St. Paul MN, US
David Walsh - Hollywood SC, US

International Classification:

A61K031/015

US Classification:

514/763000

Abstract:

The present invention provides a process for an industrial scale extraction and purification of xanthophylls (e.g., lutein and zeaxanthin) from plant material (e.g., alfalfa or other leafy green crops having high levels of chlorophyll). The process involves harvesting lutein rich alfalfa, extracting an oleoresin from the alfalfa leaves, saponifying the oleoresin, extracting and extracting lutein using a series of solvent extractions specific for oleoresin obtained from alfalfa or other leafy green plants.

US Patent:

56505116, Jul 22, 1997

Filed:

Dec 12, 1995

Appl. No.:

8/570786

Inventors:

Arthur J. Elliott - Aiken SC
David A. Walsh - Birmingham AL

Assignee:

BioCryst Pharmaceuticals, Inc. - Birmingham AL

International Classification:

C07D48704
C07F 96506
C07C25527

US Classification:

544280

Abstract:

Derivatives of 9-deazaguanine are prepared by reacting an aldehyde or ketone with a dialkylaminomalonate to form the corresponding enamine. The enamine is then reacted with a base to form a cyclic pyrrole. The cyclic pyrrole is reacted with an urea compound to provide a protected guanidino compound. The guanidino is converted to the desired 9-deazaguanine derivative by reacting with trifluoracetic acid or with an alkoxide or hydroxide followed by neutralization with an acid.

US Patent:

59809710, Nov 9, 1999

Filed:

Jul 18, 1995

Appl. No.:

8/503535

Inventors:

David E. Walsh - Greenville SC

Assignee:

Heart of the Valley Cooperative - Portland ND

International Classification:

A23L 120

US Classification:

426634

Abstract:

Processes are disclosed for the preparation and manufacture of dried legumes to make a quick cooking whole bean and bean paste food product which is rehydrated to a food product having the appearance and organoleptic texture of canned or conventionally prepared Mexican style refried bean product. One embodiment is the production of dehydrated bean flakes and/or powders which are instantly rehydratable. Subsequent to cleaning, sorting and washing, the beans are either milled by dry grinding or wet milling. The slurry is cooked and dried by a continuous method. Another embodiment is the production of dehydrated whole beans. Whole beans are cooked by conventional methods without pre-cooking or soaking after being sorted, cleaned, and washed. After cooking the whole beans, beans which are no longer intact and now are in the form of a slurry are separated from the intact beans. The whole beans are dried in a manner which does not disrupt their intact structure.