Edward K Doherty

US Patent:

20020187182, Dec 12, 2002

Filed:

Feb 14, 2002

Appl. No.:

10/075355

Inventors:

Hildegard Kramer - Westport CT, US
Luis Avila - Arlington MA, US
C. Philbrook - Boston MA, US
Peter Jarrett - Sudbury MA, US
Barbara Huibregtse - Shrewsbury MA, US
Liesbeth Brown - West Newton MA, US
Kenneth Messier - Griswold CT, US
Michael Bassett - Providence RI, US
Edward Doherty - Mansfield MA, US
John Traverse - Somerville MA, US

Assignee:

Genzyme Corporation

International Classification:

A61K009/70
B29C043/10

US Classification:

424/443000, 424/423000, 264/571000

Abstract:

A porous, water-absorbing fleece is made from crosslinkable biocompatible and biodegradable macromers. A solution of the macromers is frozen and vacuum-dried through lyophilization. The “fleece” formed by lyophilization is then crosslinked, for example by heat and/or an initiator of crosslinking. The resulting crosslinked material is highly water absorbent, readily swelling to at least its size before lyophilization, but retains macroporosity as well as the microporosity of a gel. Porosity and strength of the fleece can be controlled by initial polymer concentration and extent of crosslinking. The fleece materials can be used in different embodiments for applications in medicine and tissue engineering.

US Patent:

20080262581, Oct 23, 2008

Filed:

Apr 17, 2008

Appl. No.:

12/104515

Inventors:

Michael S. Barsness - Oxford MA, US
Edward J. Doherty - Mansfield MA, US

Assignee:

Transport Pharmaceuticals, Inc. - Framingham MA

International Classification:

A61N 1/00

US Classification:

607115

Abstract:

An apparatus to monitor current density in the application of medicament to a treatment site of a mammalian user of a electrokinetic device including: an applicator cartridge including an active electrode, a matrix carrying a medicament or a medicament and an electrically conductive carrier; a device including an electrical power source connectable to the active electrode, a counter electrode, and an electronic circuit configured to control the application of electrical current through the active electrode to establish a conductive path extending from the power source, through the active electrode, matrix, the treatment site, the user and the counter electrode electrically connected to the power source, and an array of contacts monitoring current density flowing through the matrix and to the treatment site, wherein the array of sensors are arranged monitor the current density at various locations of the matrix and a contact area between the matrix and skin above the treatment site.

US Patent:

50026615, Mar 26, 1991

Filed:

Aug 25, 1989

Appl. No.:

7/398739

Inventors:

William L. Chick - Wellesley MA
Susan J. Sullivan - Newton MA
Kermit M. Borland - Worcester MA
John M. Harvey - Worcester MA
Thomas E. Muller - Concord MA
Karen E. Dunleavy - Billerica MA
Donald P. King - Haverhill MA
Edward J. Doherty - Waltham MA
Barry A. Solomon - Bedford MA
Amy L. Foley - Framingham MA

Assignee:

W. R. Grace & Co.-Conn. - Lexington MA

International Classification:

B01D 6306

US Classification:

210192

Abstract:

A device which serves as an artificial pancreas comprises a hollow fiber having an inner diameter of about 5 mm which is surrounded by islets of Langerhans enclosed in a housing. The islets are suspended in a semi-solid matrix which ensures desired distribution of the cells about the hollow fiber. The hollow fiber and suspended islets are enclosed in a housing which further aids the desired distribution of islets about the hollow fiber. The hollow fiber has a porosity which selectively allows passage of substances having a molecular weight of less than about 100,000 Daltons. The semi-solid matrix in which the islets are embedded and suspended is formed of an appropriate supporting material such as alginate or agar.

US Patent:

41952278, Mar 25, 1980

Filed:

Jun 20, 1978

Appl. No.:

5/917356

Inventors:

Richard W. Carman - Foxboro MA
Edward J. Doherty - Halifax MA

Assignee:

Union Carbide Corporation - New York NY

International Classification:

G02B 500

US Classification:

250505

Abstract:

Scanning apparatus is provided for a movable array of highly focused collimators surrounding a scan field.

US Patent:

20170246281, Aug 31, 2017

Filed:

Feb 16, 2017

Appl. No.:

15/434781

Inventors:

- Cambridge MA, US
Edward J. Doherty - Mansfield MA, US
Mark Cartwright - West Newton MA, US
Des White - Boston MA, US
Alexander G. Stafford - Revere MA, US
Omar Abdel-Rahman Ali - Cambridge MA, US
Amanda Graveline - Boston MA, US
Donald E. Ingber - Boston MA, US
David J. Mooney - Sudbury MA, US
Benjamin Seiler - Boston MA, US

International Classification:

A61K 39/108
A61K 39/02

Abstract:

The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.