Edward B Rice

US Patent:

6555061, Apr 29, 2003

Filed:

Oct 5, 2000

Appl. No.:

09/684716

Inventors:

Koon-wah Leong - Sunnyvale CA
Yeung Siu Yu - Pleasanton CA
Edward Gray Rice - Palo Alto CA

Assignee:

Lifescan, Inc. - Milpitas CA

International Classification:

G01N 3348

US Classification:

422 58, 436169, 436177, 436178

Abstract:

A reagent test strip for measuring an analyte concentration in a biological fluid has a spreading mesh sandwiched between a support and a reagent matrix. The support has a through hole that is covered by the mesh. In use, a sample of the fluid is applied through the hole in the support to the spreading mesh. The sample then passes through the mesh to the matrix, which contains a reagent that indicates the analyte concentration by causing a corresponding change in reflectance at its free surface. Optionally, an adhesive layer attaches the mesh, and optionally the matrix as well, to the support.

US Patent:

6800488, Oct 5, 2004

Filed:

Dec 13, 2000

Appl. No.:

09/737179

Inventors:

Tahir Sadik Khan - San Jose CA
Yeung Siu Yu - Pleasanton CA
Edward G. Rice - Palo Alto CA

Assignee:

LifeScan, Inc. - Milpitas CA

International Classification:

G01N 2175

US Classification:

436166, 436169, 436170, 422 58

Abstract:

Methods for making reagent test strips are provided. In the subject methods, a test strip precursor made up of an elongated support material having a planar surface and a narrow stripe of reagent material positioned along its central axis is cut according to an inter-digitating pattern to produce the plurality of reagent test strips. The initial precursor material may be a tape or in the form of a card. Also provided are the reagent test strips produced by the subject methods and kits that include the same. The subject reagent test strips and kits find use in analyte detection and/or concentration determination assays.

US Patent:

20040028557, Feb 12, 2004

Filed:

Apr 29, 2003

Appl. No.:

10/426458

Inventors:

Koon-Wah Leong - Sunnyvale CA, US
Yeung Yu - Pleasanton CA, US
Edward Rice - Palo Alto CA, US

International Classification:

G01N031/22

US Classification:

422/056000

Abstract:

A reagent test strip for measuring an analyte concentration in a biological fluid has a spreading mesh sandwiched between a support and a reagent matrix. The support has a through hole that is covered by the mesh. In use, a sample of the fluid is applied through the hole in the support to the spreading mesh. The sample then passes through the mesh to the matrix, which contains a reagent that indicates the analyte concentration by causing a corresponding change in reflectance at its free surface. Optionally, an adhesive layer attaches the mesh, and optionally the matrix as well, to the support.

US Patent:

46253882, Dec 2, 1986

Filed:

Dec 7, 1983

Appl. No.:

6/558923

Inventors:

Edward J. Rice - Los Gatos CA

Assignee:

Acrian, Inc. - San Jose CA

International Classification:

H01L 2122

US Classification:

29571

Abstract:

A mesa structure field effect transistor includes a semiconductor body with at least one mesa formed on a major surface and an insulating layer on the mesa and overhanging the mesa. Doped regions in the side walls of the mesa define the channel region and source of the transistor, and the semiconductor body defines and drain region. Preferential etching techniques are employed in forming the mesas and the overhanging insulator. The overhanging insulator is employed as a shadow mask in fabricating the transistor.

US Patent:

58436910, Dec 1, 1998

Filed:

Dec 31, 1996

Appl. No.:

8/779735

Inventors:

Joel Douglas - Santa Clara CA
Ernest Kiser - Los Altos CA
Michael F. Tomasco - Cupertino CA
Remedios Dato - Pleasanton CA
Edward G. Rice - Palo Alto CA
Deborah P. Tuohy - Cupertino CA
Mark Maxson - San Jose CA
Zbigniew Witko - San Jose CA
Scott Segelke - Mountain View CA

Assignee:

Lifescan, Inc. - Milpitas CA

International Classification:

C12Q 154
C12Q 128
G01N 2100

US Classification:

435 14

Abstract:

A multilayer reagent test strip measures the concentration of analyte in a liquid sample that is applied to it. The sample is guided to a number of assay areas arrayed along the strip, where the analyte can react with a reagent to cause a color change. Each assay area also includes an inhibitor for the color-change reaction. The inhibitor concentration increases in successive assay areas; thus, the number of areas that change color is a measure of the analyte concentration. The test strip is particularly adapted for measuring glucose in a whole blood sample. In a preferred embodiment, the sample is guided to the assay areas along a path formed by crushing selected areas of a membrane, and the assay areas are uncrushed areas of the membrane.

US Patent:

D3815919, Jul 29, 1997

Filed:

May 31, 1996

Appl. No.:

D/055217

Inventors:

Edward G. Rice - Palo Alto CA
Ernest J. Kiser - Los Altos CA
Karen R. Drexler - Los Altos CA
Jennifer Hahamian - Sunnyvale CA
Joel S. Douglas - Santa Clara CA
Victoria Page - San Jose CA

Assignee:

LifeScan, Inc. - Milpitas CA

International Classification:

1004

US Classification:

D10 81

US Patent:

53066235, Apr 26, 1994

Filed:

Jul 26, 1991

Appl. No.:

7/736537

Inventors:

Ernest J. Kiser - Los Altos CA
Edward G. Rice - Palo Alto CA
Michael F. Tomasco - Mountain View CA

Assignee:

Lifescan, Inc. - Mountain View CA

International Classification:

C12Q 154
C12Q 126
C12Q 128
G01N 2100

US Classification:

435 14

Abstract:

A separation matrix impregnated with a separating agent separates red blood cells or hemoglobin from whole blood. Upon separation, an impregnated test reagent reacts with the separated substantially clear component fluid to form a colored product which enables a visual or meter test for analyte levels in whole blood. Such a test is appropriate for, among other things measuring glucose, cholesterol, or alcohol levels in whole blood samples. A visual meter is disclosed which allows sample to be applied to one side of the strip, and reading takes place on the opposite side, after separation of red blood cells and reaction to test reagent. Also, a useful test strip format is disclosed.

US Patent:

44198116, Dec 13, 1983

Filed:

Apr 26, 1982

Appl. No.:

6/371599

Inventors:

Edward J. Rice - Los Gatos CA

Assignee:

Acrian, Inc. - Los Gatos CA

International Classification:

H01L 2122

US Classification:

29571

Abstract:

A mesa structure field effect transistor includes a semiconductor body with at least one mesa formed on a major surface and an insulating layer on the mesa and overhanging the mesa. Doped regions in the side walls of the mesa define the channel region and source of the transistor, and the semiconductor body defines the drain region. Preferential etching techniques are employed in forming the mesas and the overhanging insulator. The overhanging insulator is employed as a shadow mask in fabricating the transistor.