Eugene Chiang

US Patent:

20200172620, Jun 4, 2020

Filed:

Feb 11, 2020

Appl. No.:

16/788003

Inventors:

- South San Francisco CA, US
Eugene Yu-Chuan CHIANG - Menlo Park CA, US
Jane Louise GROGAN - San Francisco CA, US
Simon-Peter WILLIAMS - Redwood City CA, US
Matthew Lawrence ALBERT - San Francisco CA, US

Assignee:

Genentech, Inc. - South San Francisco CA

International Classification:

C07K 16/28
A61K 35/17
A61K 47/65
G01N 33/58
A61K 39/00

Abstract:

Provided are anti-CD8 antibodies that bind human CD8 and do not stimulate or inhibit the activation of CD8 T cells. Also provided are nucleic acids encoding such anti-CD8 antibodies, vectors comprising such nucleic acids, host cells comprising same, and methods of making such anti-CD8 antibodies. Also provided are anti-CD8 antibodies conjugated to a detectable label. Provided are methods of using such anti-CD8 antibodies to detect CD8 T cells in a subject, monitor disease progress in a subject having cancer, and monitor treatment progress in a subject having cancer.