Frances Wong

US Patent:

20050025822, Feb 3, 2005

Filed:

May 27, 2004

Appl. No.:

10/856559

Inventors:

Frances Wong - Redwood City CA, US
Anuk Das - Wayne PA, US
Jonathan Seideman - New York NY, US
Luke Guo - Lafayette CA, US
Anthony Huang - Saratoga CA, US

International Classification:

A61K009/127
C12N015/88

US Classification:

424450000, 435458000

Abstract:

A method for administering a therapeutic or diagnostic agent to a subject is described. The method includes providing a suspension of liposomes comprised of one or more of vesicle-forming lipids selected from (i) a vesicle-forming lipid derivatized with a hydrophilic polymer and (ii) a neutral lipopolymer, said liposomes being associated with said therapeutic or diagnostic agent, forming an aerosol of said liposome suspension; and administering the aerosol to the subject by inhalation. The liposome formulation delivers intact liposomal particles to the respiratory tract of said subject to form a depot of therapeutic agent therein with no observable provocation of an immune response, as measured by neutrophil or macrophage cell count in the lung after administration.

US Patent:

20060269542, Nov 30, 2006

Filed:

Apr 20, 2006

Appl. No.:

11/408441

Inventors:

Kristen Hjortsvang - Fremont CA, US
Luke Guo - Lafayette CA, US
Frances Wong - Smithfield RI, US
Azar Najafi - Danville CA, US
Anthony Huang - Saratoga CA, US
Robert Abra - San Francisco CA, US
Laura Kelley - Santa Cruz CA, US

International Classification:

A61K 39/395
A61K 9/127

US Classification:

424133100, 424450000

Abstract:

An immunoliposome composition comprised of liposomes bearing a ligand for targeting to cells expressing a growth factor receptor, such as HER2, is described. Binding of the immunoliposome to HER2-expressing cells results in internalization of the immunoliposome for cytoplasmic delivery of an entrapped drug.