Frederic J Kaye

US Patent:

7214488, May 8, 2007

Filed:

Jul 3, 2002

Appl. No.:

10/479546

Inventors:

Frederic J. Kaye - Potomac MD, US
Giovanni Tonon - Watertown MA, US

Assignee:

United States of America, Represented by the Secretary, Department of Health and Human Services - Washington DC

International Classification:

C12Q 1/68
C12P 19/34
G01N 33/53
G01N 33/48

US Classification:

435 6, 435 912, 435 71, 435 405

Abstract:

The present invention provides methods and compositions for the diagnosis and treatment of cancer, including cancers involving the NOTCH pathway. In particular, the present invention provides methods and compositions for the diagnosis of mucoepidermoid carcinoma, the most common malignant salivary gland tumor. The present invention further provides methods and compositions for the diagnosis of other tumors associated with the t(11;19)(q14–21;12–13) translocation.

US Patent:

7553822, Jun 30, 2009

Filed:

Oct 30, 2003

Appl. No.:

10/698070

Inventors:

Frederic J. Kaye - Potomac MD, US
Takefumi Komiya - Osaka, JP

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

A61K 31/70
C07H 21/40
C12N 15/00

US Classification:

514 44, 536 231, 536 245, 4353201

Abstract:

Composition for the inhibition of the translation of a Mect1-MAML2 chimeric gene consisting essentially of: (a) a fragment of the nucleic acid encoding the chimeric gene, and (b) a nucleic acid complementary to the fragment, and a method of inhibiting the translation of a Mect1-MAML2 chimeric gene comprising contacting a cell expressing the chimeric gene with the composition, whereupon the translation of the chimeric gene is inhibited.

US Patent:

8124753, Feb 28, 2012

Filed:

Jun 29, 2009

Appl. No.:

12/493901

Inventors:

Frederic J. Kaye - Potomac MD, US
Takefumi Komiya - Osaka, JP

Assignee:

The United States of America as represented by the Department of Health and Human Services - Washington DC

International Classification:

C07H 21/04
A61K 31/70

US Classification:

536 245, 514 44

Abstract:

Composition for the inhibition of the translation of a Mect1-MAML2 chimeric gene consisting essentially of: (a) a fragment of the nucleic acid encoding the chimeric gene, and (b) a nucleic acid complementary to the fragment, and a method of inhibiting the translation of a Mect1-MAML2 chimeric gene comprising contacting a cell expressing the chimeric gene with the composition, whereupon the translation of the chimeric gene is inhibited.

US Patent:

56462492, Jul 8, 1997

Filed:

Feb 28, 1994

Appl. No.:

8/203905

Inventors:

Frederic J. Kaye - Bethesda MD
Gregory A. Otterson - Columbia MD

Assignee:

The United States of America as represented by the Department of Health
and Human Services - Washington DC

International Classification:

C07K 900

US Classification:

530350

Abstract:

This invention relates to the identification and molecular characterization of the human and rat STCH chaperone protein including the corresponding gene sequence, gene fragments and protein fragments. The invention also relates antibodies to STCH and to assays to detect the presence of STCH genes, transcripts and protein in a sample.