Azra Raza - Chicago IL, US Harvey Preisler - Chicago IL, US
International Classification:
C12Q001/70 C12Q001/68
US Classification:
435/005000, 435/006000
Abstract:
The present invention relates first, to the identification of a novel retrovirus and the novel nucleotide sequences encoding a retroviral polymerase gene (POL nucleotides) associated with the existence of MDS and MDS associated disorders. The present invention further relates to methods for using the MDS associated retroviral nucleotides for the detection of MDS and MDS associated disorders in patient samples. The present invention also relates to methods for using and targeting the MDS associated retroviral POL nucleotides in gene therapy protocols for the treatment of MDS and MDS associated disorders in patients in need of such treatment. The present invention further relates to diagnostic protocols and kits for the detection of MDS and MDS associated disorders in tissue samples.
Binding-Specific Peptides, Binding-Specific Carrier Molecules, And Uses Thereof
The present invention provides peptides that bind cells differentially that are capable of discriminating between normal and malignant cells, and uses of such peptides and specific carrier molecules for screening the binding reactivity of peptides from leukemia cells.