Hua L Lin

US Patent:

7087896, Aug 8, 2006

Filed:

Dec 27, 2004

Appl. No.:

11/023234

Inventors:

Christopher H. Becker - Palo Alto CA, US
Curtis A. Hastings - Bethesda MD, US
Scott M. Norton - Durham NC, US
Sushmita Mimi Roy - Santa Clara CA, US
Weixun Wang - Mountain View CA, US
Haihong Zhou - Mountain View CA, US
Thomas Andrew Shaler - Fremont CA, US
Praveen Kumar - Santa Clara CA, US
Markus Anderle - Campbell CA, US
Hua Lin - Sunnyvale CA, US

Assignee:

PPD Biomarker Discovery Sciences, LLC - Wilmington NC

International Classification:

B01D 59/44
H01J 49/00

US Classification:

250282, 250281

Abstract:

Relative quantitative information about components of chemical or biological samples can be obtained from mass spectra by normalizing the spectra to yield peak intensity values that accurately reflect concentrations of the responsible species. A normalization factor is computed from peak intensities of those inherent components whose concentration remains constant across a series of samples. Relative concentrations of a component occurring in different samples can be estimated from the normalized peak intensities. Unlike conventional methods, internal standards or additional reagents are not required. The methods are particularly useful for differential phenotyping in proteomics and metabolomics research, in which molecules varying in concentration across samples are identified. These identified species may serve as biological markers for disease or response to therapy.

US Patent:

20100062471, Mar 11, 2010

Filed:

Sep 29, 2006

Appl. No.:

12/088228

Inventors:

Aaron B. Kantor - San Carlos CA, US
Susan Goelz - Portland OR, US
Jun Deng - Cupertino CA, US
Hua Lin - Fremont CA, US
Christopher Becker - Palo Alto CA, US

Assignee:

PPD BIOMARKER DISCOVERY SCIENCES LLC - Wilmington NC
BIOGEN IDEC MA INC. - Cambridge MA

International Classification:

C12Q 1/02

US Classification:

435 29

Abstract:

Biomarkers useful for identifying treatments for and monitoring treatment of patients with multiple sclerosis (MS) are provided, as well as methods for their identification, methods of diagnosing MS, relapse of MS patients and disease progression in MS patients.

US Patent:

20120013580, Jan 19, 2012

Filed:

Jul 15, 2011

Appl. No.:

13/183676

Inventors:

Hua LIN - Fremont CA, US
Xudong Mike CUI - Fremont CA, US

International Classification:

G09G 5/00

US Classification:

345204

Abstract:

Systems, methods, and other embodiments associated with controlling pixels of a display are described. According to one embodiment, an apparatus includes a frame counter logic configured to maintain a global frame counter to track a number of refreshes of a display while updating pixels. The frame counter logic is also configured to determine a frame number when updating a pixel. The apparatus also includes a pixel logic configured to update the pixel.

US Patent:

61040282, Aug 15, 2000

Filed:

May 29, 1998

Appl. No.:

9/086993

Inventors:

Joanna M. Hunter - Redwood City CA
Hua Lin - Alameda CA
Christopher H. Becker - Palo Alto CA

Assignee:

GeneTrace Systems Inc. - Alameda CA

International Classification:

H01J 4404

US Classification:

250288

Abstract:

A sample preparation method is disclosed for volatilization and mass spectrometric analysis of nonvolatile high molecular weight molecules. Photoabsorbing molecules having significant sublimation rates at room temperature under vacuum, and preferably containing hydroxy functionalities, are disclosed for use as matrices in matrix-assisted laser desorption/ionization mass spectrometry. The samples are typically cooled in the mass spectrometer to temperatures significantly below room temperature.

US Patent:

6265716, Jul 24, 2001

Filed:

Feb 29, 2000

Appl. No.:

9/515357

Inventors:

Joanna M. Hunter - Castro Valley CA
Hua Lin - Fremont CA
Christopher H. Becker - Palo Alto CA

Assignee:

GeneTrace Systems, Inc. - Alameda CA

International Classification:

H01J 4404

US Classification:

250288

Abstract:

A sample preparation method is disclosed for volatilization and mass spectrometric analysis of nonvolatile high molecular weight molecules. Photoabsorbing molecules having significant sublimation rates at room temperature under vacuum, and preferably containing hydroxy functionalities, are disclosed for use as matrices in matrix-assisted laser desorption/ionization mass spectrometry. The samples are typically cooled in the mass spectrometer to temperatures significantly below room temperature.

US Patent:

20220185797, Jun 16, 2022

Filed:

Mar 25, 2020

Appl. No.:

17/598695

Inventors:

- New York NY, US
- Weston MA, US
Donald W. LANDRY - New York NY, US
Robert J. DEVITA - Westfield NJ, US
Hua V. LIN - Zionsville IN, US
Yunkyoung LEE - New York NY, US
Domenico ACCILI - New York NY, US
Sandro BELVEDERE - Weston MA, US

International Classification:

C07D 403/04
A61K 31/713
A61K 31/4184
A61K 31/496
C07D 401/14
A61K 31/454
C07D 405/14
C07D 413/14
A61K 31/423
A61K 31/4709
A61K 31/4439
C07D 471/04
A61K 31/437

Abstract:

Various embodiments relate to a compound (represented by Formula I) or a pharmaceutically acceptable salt or tautomer thereof. The compound may selectively inhibit a Forkhead Box O1 (FOXO1) transcription factor. Various embodiments relate to methods comprising administering to a mammal having a disease or disorder associated with impaired pancreatic endocrine function, a therapeutically effective amount of the compound or a pharmaceutically acceptable salt or tautomer thereof. Various embodiments relate to methods for producing enteroendocrine cells that make and secrete insulin in a mammal, comprising administering to the mammal an effective amount of the compound or a pharmaceutically acceptable salt or tautomer thereof.

US Patent:

20200362385, Nov 19, 2020

Filed:

Mar 17, 2020

Appl. No.:

16/821285

Inventors:

- Menlo Park CA, US
Hua Lin - Fremont CA, US

International Classification:

C12Q 1/04
C12M 1/12

Abstract:

Various examples are directed to kits, apparatuses, and methods for determining a presence of (BP) in a biological sample. An example method includes causing a physical interaction between a biological sample from a subject and a set of first agents by exposing the biological sample to the set of first agents, the set of first agents being specific to one or more of a set of BP biomarkers associated with one or more proteins released from BP or associated with other molecules released from BP. The method further includes determining a presence of BP in the biological sample based on detected binding between one or more of the set of first agents and the one or more of the set of BP biomarkers.

US Patent:

20180321228, Nov 8, 2018

Filed:

Jul 23, 2018

Appl. No.:

16/042108

Inventors:

- Menlo Park CA, US
Robert BALOG - MENLO PARK CA, US
Polly CHANG - MENLO PARK CA, US
Thomas A. SHALER - MENLO PARK CA, US
Hua LIN - MENLO PARK CA, US
Annalisa D'ANDREA - MENLO PARK CA, US
Travis HARRISON - MENLO PARK CA, US
Roger H. SCHMIDT - MENLO PARK, UA
Christina SWANSON - MENLO PARK CA, US
Estevan MENDOZA - MENLO PARK CA, US
Mark STEELE - MENLO PARK CA, US
Pablo E. GARCIA - MENLO PARK CA, US

International Classification:

G01N 33/53
G01N 33/49
G01N 33/558
G01N 33/68

Abstract:

Materials, systems and methods are provided for qualitative assessment of exposure of a person to ionizing radiation by measuring amounts of the biomarkers, wherein a change compared with corresponding un-irradiated control reference ranges of the biomarkers, provides the assessment, wherein the biomarkers include (i) alpha-1-Antichymotrypsin (ACT), (ii) Fms-related tyrosine kinase 3 ligand (Flt3L), and (iii) one or more additional proteins.