Hui Li

US Patent:

6380189, Apr 30, 2002

Filed:

Feb 11, 2000

Appl. No.:

09/502038

Inventors:

Norman Abood - Morton Grove IL
Daniel L. Flynn - Mundelein IL
Daniel P. Becker - Glenview IL
Brian M. Bax - St. Lcharles IL
Hui Li - Skokie IL
Roger A. Nosal - Buffalo Grove IL
Lori A. Schretzman - Gurnee IL
Clara I. Villamil - Glenview IL

Assignee:

G.D. Searle Co. - Chicago IL

International Classification:

A61K 31536

US Classification:

5142305, 544 92

Abstract:

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R are as defined herein, or a pharmaceutically-acceptable salt thereof.

US Patent:

6683077, Jan 27, 2004

Filed:

Jan 4, 2002

Appl. No.:

10/035433

Inventors:

Norman Abood - Morton Grove IL
Daniel L. Flynn - Mundelein IL
Daniel P. Becker - Glenview IL
Brian M. Bax - Irvine CA
Hui Li - Vernon Hills IL
Roger A. Nosal - Buffalo Grove IL
Lori A. Schretzman - Gurnee IL
Clara I. Villamil - Glenview IL

Assignee:

G.D. Searle Co. - St. Louis MO

International Classification:

A61K 31535

US Classification:

5142305, 544 92

Abstract:

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R are as defined herein, or a pharmaceutically-acceptable salt thereof.

US Patent:

7848558, Dec 7, 2010

Filed:

Feb 13, 2004

Appl. No.:

10/777041

Inventors:

Maryellen L. Giger - Elmhurst IL, US
Hui Li - Chicago IL, US

Assignee:

The University of Chicago - Chicago IL

International Classification:

G06K 9/00

US Classification:

382132, 382155, 382129

Abstract:

A computerized method, system and computer program for the computerized fractal-based analysis of a structure as presented in a pattern on a medical image. Image data is generated from the medical image and a region of interest is selected. The image data is digitized and analyzed to reveal fractal-based computer-generated features of a texture of the image data. Then a qualifier is applied to the computer-generated features to obtain fractal characteristics of the image data. A multi-fractal nature is observed for the texture of the region of interest. A marker for assessing a risk of a disease is yielded based on the multi-fractal nature of the texture.

US Patent:

20050032793, Feb 10, 2005

Filed:

Dec 8, 2003

Appl. No.:

10/728946

Inventors:

Norman Abood - Morton Grove IL, US
Daniel Flynn - Mundelein IL, US
Daniel Becker - Glenview IL, US
Brian Bax - Irvine CA, US
Hui Li - Vernon Hills IL, US
Roger Nosal - Buffalo Grove IL, US
Lori Schretzman - Gurnee IL, US
Clara Villamil - Glenview IL, US

Assignee:

G.D. Searle & Co. - Chicago IL

International Classification:

C07D265/12
A61K031/535

US Classification:

514230500, 544092000

Abstract:

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-Rare as defined herein, or a pharmaceutically-acceptable salt thereof.

US Patent:

20060106712, May 18, 2006

Filed:

Oct 31, 2005

Appl. No.:

11/163808

Inventors:

Min Guo - Long Grove IL, US
Hui Li - Long Grove IL, US

International Classification:

G06Q 40/00

US Classification:

705037000

Abstract:

Methods and apparatus are described for facilitating transactions between a plurality of buyers and a plurality of sellers via the Internet. Product information relating to a plurality of products meeting product criteria specified by a group of buyers is presented via the Internet. Buyers place requests for products at desired levels. The mechanism automatically aggregates the buying power and bundles it for sellers to bid on. The present invention provides an easy B2C/B2B mechanism for sellers as well as a mechanism for buyers to benefit from wholesale prices.

US Patent:

20120189176, Jul 26, 2012

Filed:

Nov 28, 2011

Appl. No.:

13/305495

Inventors:

Maryellen L. Giger - Elmhurst IL, US
Robert Tomek - Chicago IL, US
Jeremy Bancroft Brown - Chicago IL, US
Andrew Robert Jamieson - Chicago IL, US
Li Lan - Hinsdale IL, US
Michael R. Chinander - Chicago IL, US
Karen Drukker - Crete IL, US
Hui Li - Naperville IL, US
Neha Bhooshan - Potomac MD, US
Gillian Newstead - Chicago IL, US

International Classification:

G06K 9/46

US Classification:

382128

Abstract:

Computerized interpretation of medical images for quantitative analysis of multi-modality breast images including analysis of FFDM, 2D/3D ultrasound, MRI, or other breast imaging methods. Real-time characterization of tumors and background tissue, and calculation of image-based biomarkers is provided for breast cancer detection, diagnosis, prognosis, risk assessment, and therapy response. Analysis includes lesion segmentation, and extraction of relevant characteristics (textural/morphological/kinetic features) from lesion-based or voxel-based analyses. Combinations of characteristics in several classification tasks using artificial intelligence is provided. Output in terms of 1D, 2D or 3D distributions in which an unknown case is identified relative to calculations on known or unlabeled cases, which can go through a dimension-reduction technique. Output to 3D shows relationships of the unknown case to a cloud of known or unlabeled cases, in which the cloud demonstrates the structure of the population of patients with and without the disease.

US Patent:

59454253, Aug 31, 1999

Filed:

Oct 24, 1996

Appl. No.:

8/737251

Inventors:

Alan E. Moormann - Skokie IL
Daniel P. Becker - Glenview IL
Daniel L. Flynn - Mundelein IL
Hui Li - Skokie IL
Clara I. Villamil - Glenview IL

Assignee:

G.D. Searle & Co. - Skokie IL

International Classification:

A61K 3142
A61K 31415
A61K 31425

US Classification:

514269

Abstract:

A class of compounds which are (H. sup. + /K. sup. +)ATPase inhibitors can be used for the treatment of viral infections. Compounds of particular interest are defined by Formula III: ##STR1## wherein D is N or CH; wherein R. sup. 7 is one or more radicals selected from hydrido, alkoxy, amino, cyano, nitro, hydroxyl, alkyl, halo, haloalkyl, carboxyl, alkanoyl, nitro, amino, alkylamino, aminocarbonyl, aminosulfonyl, alkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonyl, alkylaminosulfonyl, alkylsulfonylamino, alkylthio, alkylsulfinyl and alkylsulfonyl; wherein R. sup. 8 is selected from hydrido, alkyl and cycloalkyl; wherein R. sup. 9 is one or more radicals selected from hydrido, alkoxy, amino, alkyl, halo, cyano, nitro, hydroxyl, haloalkyl, nitro, carboxyl, alkanoyl, amino, alkylamino, dialkylamino, aminocarbonyl, alkylaminocarbonyl, alkylcarbonylamino, aminosulfonyl, alkylaminosulfonyl, alkylsulfonylamino, alkoxycarbonyl, alkylthio, alkylsulfinyl and alkylsulfonyl; and wherein R. sup. 10 and R. sup. 11 are independently selected from hydrido, alkyl, aryl, alkylcarbonyl and arylcarbonyl wherein the aryl ring may be further substituted with one or more radicals selected from alkyl, halo, hydrazidylcarbonyl, aminocarbonyl and alkoxy; or wherein R. sup. 10 and R. sup. 11 together with the nitrogen atom form a heterocyclic ring.

US Patent:

59858729, Nov 16, 1999

Filed:

May 24, 1995

Appl. No.:

8/448795

Inventors:

Norman Anthony Abood - Morton Grove IL
Daniel L. Flynn - Libertyville IL
Daniel P. Becker - Glenview IL
Brian M. Bax - St. Charles IL
Hui Li - Skokie IL
Roger A. Nosal - Buffalo Grove IL
Lori A Schretzman - Gurnee IL
Clara I Villamil - Glenview IL

Assignee:

G.D. Searle & Co. - Chicago IL

International Classification:

A61K 31535
C07D26522

US Classification:

5142305

Abstract:

A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula II ##STR1## wherein R. sup. 28 is selected from (a) amino substituted with one or two radicals selected from alkyl, aralkyl, heterocycoalkyl, heterocyclo, and aryl, and (b) amino acid residues and derivatives thereof; wherein R. sup. 29 is selected from hydrido, alkyl, halo, ##STR2## wherein R. sup. 30 is selected from alkyl, alkoxy, alkylamino, carboxyalkyl, alkoxyalkyl, alkylaminoalkyl, cycloalkyl, heterocyclo, heterocycloalkyl, heterocycloalkoxy, alkylaminoalkoxy, alkylaminoalkylamino, heterocycloalkylamino, and N-aralkylamino; wherein R. sup. 31 is alkyl; wherein R. sup. 32 is alkyl and aryl; or a pharmaceutically-acceptable salt thereof.