Hui H Xie

US Patent:

8086427, Dec 27, 2011

Filed:

Aug 7, 2006

Appl. No.:

11/462804

Inventors:

Tong Fang - Morganville NJ, US
Gozde Unal - West Windsor NJ, US
Fred McBagonluri - East Windsor NJ, US
Alexander Zouhar - Hillsborough NJ, US
Hui Xie - Plainsboro NJ, US
Gregory G. Slabaugh - Princeton NJ, US
Jason Jenn-Kwei Tyan - Princeton NJ, US

Assignee:

Siemens Corporation - Iselin NJ

International Classification:

G06F 7/60
G06K 9/00
G06T 15/00

US Classification:

703 2, 382128, 345419

Abstract:

A method of designing hearing aid molds is disclosed whereby two shapes corresponding to graphical images of ear impressions are registered with each other to facilitate joint processing of the hearing aid design. In a first embodiment, a first graphical representation of a first ear impression is received and a feature, such as the aperture of the ear impression, is identified on that graphical model. A first vector is generated that represents the orientation and shape of that first feature. The three-dimensional translation and rotation of that first vector are determined that are necessary to align the first vector with a second vector representing the orientation and a shape of a feature, once again such as the aperture, of a second ear impression. In another embodiment, this alignment is then refined by minimizing the sum of the distances between points on the first and second graphical representations.

US Patent:

20090247734, Oct 1, 2009

Filed:

Dec 14, 2006

Appl. No.:

12/086675

Inventors:

Wayne A. Hendrickson - New York NY, US
Hui Xie - New York NY, US
Amos B. Smith - Merion PA, US
Danny Ng - Daly City CA, US

International Classification:

C07K 14/73
G06G 7/48

US Classification:

530380, 703 11

Abstract:

This invention provides two soluble polypeptides which comprise a portion of CD4 comprising all HIV gp120-binding epitopes present on intact CD4, wherein the polypeptide has a cysteine substitution at a residue which, in intact CD4, interfaces with HIV gp120. This invention also provides a method for making a derivatized soluble polypeptide and a method for obtaining a structural model useful in the design of an agent for inhibiting CD4 binding to HIV gp120.