Hui H Xu

US Patent:

20110054588, Mar 3, 2011

Filed:

Aug 24, 2010

Appl. No.:

12/862033

Inventors:

Hui Xu - Plainsboro NJ, US
Cunqi Cui - Plainsboro NJ, US
Joshua Czeczuga - Brick NJ, US
Jared Lombardi - Somerset NJ, US

International Classification:

A61F 2/82
B29C 63/04
B29C 65/62
B29C 65/72
B29C 63/18

US Classification:

623 113, 623 144, 156187, 156 93, 156196, 156184

Abstract:

A vascular graft for treatment of diseased or damaged blood vessels is disclosed. The graft comprises a sheet of acellular tissue matrix with an intact basement membrane. The graft is formed by wrapping the sheet into a tube and securing the edges of the sheet together. The acellular tissue matrix facilitates tissue ingrowth and remodeling of the graft with host cells.

US Patent:

20110135706, Jun 9, 2011

Filed:

Nov 30, 2010

Appl. No.:

12/956058

Inventors:

Hui Xu - Plainsboro NJ, US
Wendell Sun - Warrington PA, US
Cunqi Cui - East Windsor NJ, US
Hua Wan - Princeton NJ, US

International Classification:

A61K 35/44
A61K 9/10
A61K 38/39
A61P 25/02

US Classification:

424423, 424484, 424569, 424 931, 514 182

Abstract:

Devices and methods for treating defects in peripheral nerves are provided. The devices can include acellular arterial tissue matrices that facilitate regrowth of nerve tissue across a gap or defect in a peripheral nerve.

US Patent:

20130028984, Jan 31, 2013

Filed:

Jul 27, 2012

Appl. No.:

13/560362

Inventors:

Hui Xu - Plainsboro NJ, US
Wenquan Sun - Warrington PA, US
Hua Wan - Princeton NJ, US
Rick Owens - Stewartsville NJ, US

International Classification:

A61K 38/17
A61P 31/04
A61K 33/38
A61P 29/00
A61K 38/18

US Classification:

424618, 514 209, 514 76, 514 91, 514 81, 514 82

Abstract:

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

US Patent:

20130121970, May 16, 2013

Filed:

Nov 8, 2012

Appl. No.:

13/671729

Inventors:

Hui Xu - Plainsboro NJ, US
Wenquan Sun - Warrington PA, US

Assignee:

LIFECELL CORPORATION - Branchburg NJ

International Classification:

A61F 2/02
A61K 47/46
A61K 35/12

US Classification:

424 937, 514772, 623 2372

Abstract:

Acellular tissue matrix compositions for use in tissue approximation are provided. Also provided are methods for making and using the compositions to approximate tissue.

US Patent:

20140004549, Jan 2, 2014

Filed:

Sep 5, 2013

Appl. No.:

14/019274

Inventors:

Hui Xu - Plainsboro NJ, US
Li Ting Huang - Branchburg NJ, US
Wenquan Sun - Warrington PA, US

International Classification:

C12N 5/00

US Classification:

435 23, 435395

Abstract:

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix.

US Patent:

20200230292, Jul 23, 2020

Filed:

Apr 2, 2020

Appl. No.:

16/838512

Inventors:

- Madison NJ, US
Hui Xu - Plainsboro NJ, US
Aaron Barere - Hoboken NJ, US
Israel James Jessop - Garden Ridge TX, US
Mrinal Shah - Parsippany NJ, US
Nathaniel Bachrach - Clifton NJ, US

International Classification:

A61L 27/36
A61L 27/48
A61L 27/60
A61L 27/56
A61F 2/12

Abstract:

The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.

US Patent:

20200022798, Jan 23, 2020

Filed:

Jul 31, 2019

Appl. No.:

16/527784

Inventors:

- Madison NJ, US
Hui Xu - Plainsboro NJ, US
Wenquan Sun - Warrington PA, US

International Classification:

A61F 2/02
A61L 31/00
A61K 35/12
A61K 47/46

Abstract:

Acellular tissue matrix compositions for use in tissue approximation are provided. Also provided are methods for making and using the compositions to approximate tissue.

US Patent:

20190151507, May 23, 2019

Filed:

Jan 23, 2019

Appl. No.:

16/254939

Inventors:

- Madison NJ, US
Patrick Leamy - Flemington NJ, US
Nimesh Kabaria - Hillsborough NJ, US
Hui Xu - Plainsboro NJ, US

International Classification:

A61L 27/36
C12N 5/071
C07K 14/78
C12N 13/00

Abstract:

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can comprise treatment with alcalase under conditions controlled to produce a desired pliability without unacceptable alteration in collagen structure.