Hui Lan Yu

US Patent:

7601714, Oct 13, 2009

Filed:

Jul 6, 2005

Appl. No.:

11/175476

Inventors:

Antonio J. M. Barbosa, Jr. - Middlebury CT, US
Steven Richard Brunette - New Milford CT, US
Eugene Richard Hickey - Danbury CT, US
Jin Mi Kim - Sandy Hook CT, US
Michael David Lawlor - Seymour CT, US
René Marc Lemieux - Plantsville CT, US
Bryan McKibben - New Milford CT, US
Matt Aaron Tschantz - Newtown CT, US
Hui Yu - New Milford CT, US

Assignee:

Boehringer Ingelheim Pharmaceuticals, Inc. - Ridgefield CT

International Classification:

C07D 239/48
C07D 403/12
A61K 31/505

US Classification:

5142358, 51425505, 514275, 544122, 544295, 544323, 544324

Abstract:

Disclosed are novel compounds of formula (I):.

US Patent:

8552205, Oct 8, 2013

Filed:

Nov 20, 2008

Appl. No.:

12/745439

Inventors:

Antonio Jose del Moral Barbosa, Jr. - Middlebury NY, US
Joerg Martin Bentzien - White Plains NY, US
Steven Richard Brunette - New Milford CT, US
Zhidong Chen - New Milford CT, US
Derek Cogan - Sandy Hook CT, US
Donghong A. Gao - Hopewell Junction NY, US
Joshua Courtney Horan - Danbury CT, US
Jennifer A. Kowalski - New Milford CT, US
Michael David Lawlor - Seymour CT, US
Rene Marc Lemieux - Newtown CT, US
Weimin Liu - Sandy Hook CT, US
Bryan McKibben - New Milford CT, US
Craig Andrew Miller - Norwalk CT, US
Neil Moss - Ridgefield CT, US
Matt Aaron Tschantz - Newtown CT, US
Zhaoming Xiong - Brookfield CT, US
Hui Yu - New Milford CT, US
Yang Yu - Danbury CT, US

Assignee:

Boehringer Ingelheim International GmbH - Ingelheim am Rhein

International Classification:

A61K 31/4188
C07D 403/14
C07D 403/12
C07D 401/12
C07D 401/14

US Classification:

5483031, 544138, 544139, 544238, 544279, 544333, 546122, 546194, 546199, 5462731, 548113, 548136, 548181, 548132, 548235, 548250, 5482664

Abstract:

Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

US Patent:

20060252811, Nov 9, 2006

Filed:

Apr 4, 2006

Appl. No.:

11/278558

Inventors:

Jin Kim - Sandy Hook CT, US
Rene Lemieux - Plantsville CT, US
Bryan McKibben - New Milford CT, US
Matt Tschantz - Newtown CT, US
Hui Yu - New Milford CT, US

Assignee:

Boehringer Ingelheim International GmbH - Ingelheim

International Classification:

C07D 233/34
A61K 31/4166

US Classification:

514398000, 548326100

Abstract:

The invention comprises a class of derivatives of substituted benzylimidazoles of the formula (I) and methods for making the same. These compounds are useful for the treatment of inflammatory conditions.

US Patent:

20080287410, Nov 20, 2008

Filed:

Jul 11, 2008

Appl. No.:

12/171591

Inventors:

Antonio J.M. BARBOSA - Middlebury CT, US
Steven Richard BRUNETTE - New Milford CT, US
Eugene Richard HICKEY - Danbury CT, US
Jin Mi KIM - Sandy Hook CT, US
Michael David LAWLOR - Seymour CT, US
Rene Marc LEMIEUX - Plantsville CT, US
Bryan MCKIBBEN - New Milford CT, US
Matt Aaron TSCHANTZ - Newton CT, US
Hui YU - New Milford CT, US

International Classification:

A61K 31/505
A61K 31/397
A61P 37/00

US Classification:

5142102, 514275

Abstract:

Disclosed are novel compounds of formula (I):wherein X, Y, R, Rand Rare as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

US Patent:

20160108026, Apr 21, 2016

Filed:

Oct 14, 2015

Appl. No.:

14/882486

Inventors:

- Ingelheim am Rhein, DE
Kenneth Michael MEYERS - Seymour CT, US
Peter Allen NEMOTO - Southbury CT, US
Simon SURPRENANT - New Milford CT, US
Hui YU - New Milford CT, US

International Classification:

C07D 405/14
C07D 405/04
C07D 413/14
C07D 417/14

Abstract:

The present invention relates to compounds of formula I:and pharmaceutically acceptable salts thereof, wherein R, Rand R, are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

US Patent:

20140323468, Oct 30, 2014

Filed:

Apr 28, 2014

Appl. No.:

14/262828

Inventors:

Michael BALESTRA - New Fairfield CT, US
Jennifer BURKE - Newtown CT, US
Zhidong CHEN - New Milford CT, US
Derek COGAN - Sandy Hook CT, US
Lee FADER - New Milford CT, US
Xin GUO - Danbury CT, US
Bryan MCKIBBEN - New Milford CT, US
Daniel Richard MARSHALL - Norwalk CT, US
Peter Allen NEMOTO - Southbury CT, US
Hui YU - New Milford CT, US

Assignee:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH - Ingelheim am Rhein

International Classification:

C07D 498/04
C07D 471/04

US Classification:

5142111, 5142222, 5142305, 5142308, 5142345, 51425505, 514256, 514278, 514300, 540552, 544 3, 544105, 544127, 544333, 544405, 546 16, 546113, 546122

Abstract:

The present invention relates to compounds of formula (I):and pharmaceutically acceptable salts thereof, wherein R, R. R, R, R, R, R, W, Y, m and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.