Hui Cha Yu

US Patent:

8552205, Oct 8, 2013

Filed:

Nov 20, 2008

Appl. No.:

12/745439

Inventors:

Antonio Jose del Moral Barbosa, Jr. - Middlebury NY, US
Joerg Martin Bentzien - White Plains NY, US
Steven Richard Brunette - New Milford CT, US
Zhidong Chen - New Milford CT, US
Derek Cogan - Sandy Hook CT, US
Donghong A. Gao - Hopewell Junction NY, US
Joshua Courtney Horan - Danbury CT, US
Jennifer A. Kowalski - New Milford CT, US
Michael David Lawlor - Seymour CT, US
Rene Marc Lemieux - Newtown CT, US
Weimin Liu - Sandy Hook CT, US
Bryan McKibben - New Milford CT, US
Craig Andrew Miller - Norwalk CT, US
Neil Moss - Ridgefield CT, US
Matt Aaron Tschantz - Newtown CT, US
Zhaoming Xiong - Brookfield CT, US
Hui Yu - New Milford CT, US
Yang Yu - Danbury CT, US

Assignee:

Boehringer Ingelheim International GmbH - Ingelheim am Rhein

International Classification:

A61K 31/4188
C07D 403/14
C07D 403/12
C07D 401/12
C07D 401/14

US Classification:

5483031, 544138, 544139, 544238, 544279, 544333, 546122, 546194, 546199, 5462731, 548113, 548136, 548181, 548132, 548235, 548250, 5482664

Abstract:

Derivatives of 6,7-dihydro-5H-imidazo[1,2-α]imidazole-3-carboxylic acid amide exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are thus useful in the treatment of inflammatory disease.

US Patent:

20200009125, Jan 9, 2020

Filed:

Jun 17, 2019

Appl. No.:

16/443324

Inventors:

- North Brunswick NJ, US
Kaoru Tominaga - North Brunswick NJ, US
Hui Yu - Newtown PA, US

International Classification:

A61K 31/4545
A61K 31/4365
A61K 31/196
A61K 31/192
A61K 9/14

Abstract:

This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric-soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile.

US Patent:

20170252332, Sep 7, 2017

Filed:

May 10, 2017

Appl. No.:

15/591829

Inventors:

- North Brunswick NJ, US
Kaoru Tominaga - North Brunswick NJ, US
Hui Yu - Newtown PA, US

International Classification:

A61K 31/4545
A61K 31/4365
A61K 31/192
A61K 9/14
A61K 31/196

Abstract:

This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric-soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile.

US Patent:

20150182457, Jul 2, 2015

Filed:

Dec 30, 2014

Appl. No.:

14/585700

Inventors:

- North Brunswick NJ, US
Kaoru Tominaga - North Brunswick NJ, US
Hui Yu - Newtown PA, US

International Classification:

A61K 9/10
A61K 47/38
A61K 31/4545
A61K 47/26
A61K 31/196
A61K 31/192
A61K 31/4365
A61K 47/32

Abstract:

This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric-soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile.