Hui Jen Yu

US Patent:

20200009125, Jan 9, 2020

Filed:

Jun 17, 2019

Appl. No.:

16/443324

Inventors:

- North Brunswick NJ, US
Kaoru Tominaga - North Brunswick NJ, US
Hui Yu - Newtown PA, US

International Classification:

A61K 31/4545
A61K 31/4365
A61K 31/196
A61K 31/192
A61K 9/14

Abstract:

This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric-soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile.

US Patent:

20170252332, Sep 7, 2017

Filed:

May 10, 2017

Appl. No.:

15/591829

Inventors:

- North Brunswick NJ, US
Kaoru Tominaga - North Brunswick NJ, US
Hui Yu - Newtown PA, US

International Classification:

A61K 31/4545
A61K 31/4365
A61K 31/192
A61K 9/14
A61K 31/196

Abstract:

This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric-soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile.

US Patent:

20150182457, Jul 2, 2015

Filed:

Dec 30, 2014

Appl. No.:

14/585700

Inventors:

- North Brunswick NJ, US
Kaoru Tominaga - North Brunswick NJ, US
Hui Yu - Newtown PA, US

International Classification:

A61K 9/10
A61K 47/38
A61K 31/4545
A61K 47/26
A61K 31/196
A61K 31/192
A61K 31/4365
A61K 47/32

Abstract:

This present invention is concerned with novel solid dispersion pharmaceutical compositions for preparation of composition which is comprised of a compound with poor water solubility (a weakly basic, neutral and/or non-ionizable, or a weakly acidic compound), water-soluble polymer(s), pH-sensitive polymer(s) (either enteric polymer or gastric-soluble polymer that is soluble at gastric fluid and insoluble at intestine pH range such as Eudragit E), and/or pharmaceutical acceptable surfactant(s) that would improve the solubility/dissolution of the compound in aqueous media of both low and neutral pHs and provide a relative pH-independent dissolution profile.