Dr. Yu graduated from the Bethune Med Univ, Changchun City, Jilin, China in 1986. She works in Mineola, NY and specializes in Neurology and Neuromuscular Medicine. Dr. Yu is affiliated with Winthrop University Hospital.
A method for producing T cells expressing a chimeric antigen receptor (CAR-T cells), comprising: (i) culturing CAR-T cells in a medium comprising lenalidomide or a derivative thereof to produce CAR-T cells, and optionally (ii) administering the CAR-T cells to a subject in need of the treatment.
- Zug, CH Demetrios Kalaitzidis - Cambridge MA, US Siyuan Tan - Cambridge MA, US Hui Yu - Cambridge MA, US
International Classification:
C12N 15/90 C12N 15/11 C12N 9/22 C12N 5/0783
Abstract:
Aspects of the present disclosure relate to methods for manufacturing genetically engineered T cells expressing a chimeric antigen receptor (CAR) that provide several improvements over conventional manufacturing methods, thereby enabling production of a robust supply of clinically useful CAR T-cell therapies.