Jae J Chang

US Patent:

8394818, Mar 12, 2013

Filed:

Oct 16, 2009

Appl. No.:

13/124159

Inventors:

Nathanael Gray - Boston MA, US
Jae Won Chang - Boston MA, US
Jianming Zhang - Cambridge MA, US
Carson C. Thoreen - Jamaica Plain MA, US
Seong Woo Anthony Kang - Cambridge MA, US
David M. Sabatini - Cambridge MA, US
Qingsong Liu - Jamaica Plain MA, US

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA
Whitehead Institute for Biomedical Research - Cambridge MA

International Classification:

A61K 31/4375
C07D 471/06

US Classification:

514292, 546 81

Abstract:

The present invention relates to small molecule modulators of mTORC1 and mTORC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e. g. , benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases. Novel small molecules are provided that inhibit one or more of mTORC1, mTORC2, and PI3K-related proteins. Novel methods of providing soluble mTORC1 and mTORC2 complexes are discussed, as well as methods of using the soluble complexes in a high-throughput manner to screen for inhibitory compounds.

US Patent:

20110312908, Dec 22, 2011

Filed:

Nov 28, 2008

Appl. No.:

12/745496

Inventors:

Nathanael S. Gray - Boston MA, US
Jianming Zhang - Cambridge MA, US
Barun Okram - San Diego CA, US
Xianming Deng - Jamaica Plain MA, US
Jae Won Chang - San Diego CA, US
Amy Wojciechowski - Cheektowaga NY, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

A61K 31/7076
C07D 495/04
C07D 239/94
C07D 413/12
A61P 35/00
C07H 19/167
A61K 31/519
A61K 31/5377
A61K 31/517
A61K 31/506
C07D 487/04
C07D 471/04

US Classification:

514 46, 544262, 544117, 544278, 544293, 544122, 544328, 544281, 536 276, 5142621, 5142342, 5142601, 5142664, 5142358, 514256, 5142591

Abstract:

The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of cancers.

US Patent:

20120088766, Apr 12, 2012

Filed:

Jun 14, 2010

Appl. No.:

13/376539

Inventors:

Hwan Geun Choi - Seoul, KR
Taebo Sim - Seoul, KR
Nathanael Gray - Boston MA, US
Wenjun Zhou - Brighton MA, US
Jae Won Chang - San Diego CA, US
Jianming Zhang - Cambridge MA, US
Ellen Weisberg - Nashua NH, US

Assignee:

DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

A61K 31/5377
A61K 31/437
A61K 31/496
C12N 9/99
A61K 31/4985
A61P 35/00
A61P 35/02
C07D 513/04
A61K 31/506

US Classification:

5142342, 546114, 514301, 544362, 51425304, 544127, 544295, 51425218, 544350, 514249, 435184

Abstract:

The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.

US Patent:

20130154071, Jun 20, 2013

Filed:

Dec 14, 2011

Appl. No.:

13/325582

Inventors:

Geoffrey T. Haigh - Boxford MA, US
Matthew Kuhn - Atlanta GA, US
Patrick Melet - Sandy Springs GA, US
Romain Pelard - Atlanta GA, US
Jae Joon Chang - Johns Creek GA, US
Youngsik Hur - Alpharetta GA, US

Assignee:

Samsung Electro-Mechanics Company, Ltd. - Gyunggi-Do

International Classification:

H01L 23/495

US Classification:

257676, 257E23052

Abstract:

Systems and methods pertaining to a digital signal isolator device are described. In one embodiment, the device includes an isolation barrier and two metal support paddles. The isolation barrier contains an organic and/or a semi-organic insulating material with at least one capacitor embedded inside. One of the two metal support paddles is located below a first portion of a bottom surface of the isolation barrier to provide support to the isolation barrier, while the other metal support paddle is located below a second portion of a bottom surface of the isolation barrier to provide support to the isolation barrier.

US Patent:

20190084990, Mar 21, 2019

Filed:

Oct 25, 2018

Appl. No.:

16/170921

Inventors:

Nathanael S. Gray - Boston MA, US
Jianming Zhang - Belmont MA, US
Barun Okram - San Marcos CA, US
Xianming Deng - Kiamen, CN
Jae Won Chang - San Diego CA, US
Amy Wojciechowski - Cheektowaga NY, US

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA
The Scripps Research Institute - La Jolla CA

International Classification:

C07D 487/04
A61K 31/519
C07D 495/04
C07D 473/34
C07D 417/04
C07D 403/12
C07D 403/06
C07D 403/04
C07D 239/94
C07D 239/42
A61K 31/52
A61K 31/5377
A61K 31/7076
A61K 45/06
C07D 471/04
A61K 31/517
C07H 19/16

Abstract:

The present invention provides novel heteroaryl compounds of formula (I) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group via an amine linker. Such compounds are useful for the treatment of cancers.

US Patent:

20160095238, Mar 31, 2016

Filed:

Sep 28, 2015

Appl. No.:

14/867451

Inventors:

Jeremy Krinitt - Concord MA, US
Peter Jekel - Westford MA, US
Michael Laskowski - Pittsburgh PA, US
Jae Chang - Pittsburgh PA, US
Dan Piening - Cincinnati OH, US
Dennis Meece - Dayton OH, US
Holly Tsourides - Lowell MA, US
James Young - Boulder CO, US
Joe Fansler - Dayton OH, US
Gary Johnson - Pompton Plains NJ, US
Dave Friedeck - Rancho Cucamo CA, US
Eric Colburn - Pittsburgh PA, US

International Classification:

H05K 5/02

Abstract:

A mountable enclosure can include a base and a door pivotally connected along a vertical axis. The base and door can include electronic component mounting areas, horizontal cable management areas, and vertical cable management areas. A mounting system can include at least one enclosure and at least one bracket, the bracket having a rigid body with first, second, and third parallel surfaces wherein the first and third surfaces are on one plane and the second surface is on a different plane. The bracket can be fastened to the wall and the enclosure can be fastened to the bracket and the wall. Multiple enclosures can be installed in vertical alignment through a method that can require only one installer and the leveling of only the first bracket wherein notches in subsequent brackets are mated with pegs extending from the base of previously installed enclosures.

US Patent:

20150094275, Apr 2, 2015

Filed:

Nov 13, 2014

Appl. No.:

14/540919

Inventors:

Nathanael S. GRAY - Boston MA, US
Jianming ZHANG - Belmont MA, US
Barun OKRAM - San Diego CA, US
Xianming DENG - Xiamen, CN
Jae Won CHANG - San Diego CA, US
Amy WOJCIECHOWSKI - Cheektowaga NY, US

Assignee:

THE SCRIPPS RESEARCH INSTITUTE - La Jolla CA
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA

International Classification:

C07D 487/04
A61K 31/5377
C07D 495/04
C07D 239/94
A61K 31/517
A61K 45/06
C07D 471/04
C07D 403/04
C07H 19/16
A61K 31/7076
C07D 473/34
A61K 31/52
A61K 31/519
C07D 239/42

US Classification:

514 46, 544262, 5142621, 544117, 5142342, 544278, 5142601, 544293, 5142664, 544122, 5142358, 544328, 514256, 544281, 5142591, 536 276, 544277, 5142634

Abstract:

The present invention provides novel heteroaryl compounds having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group via an amine linker. Such compounds are useful for the treatment of cancers.

US Patent:

20150094315, Apr 2, 2015

Filed:

Jul 1, 2014

Appl. No.:

14/321242

Inventors:

- Boston MA, US
Taebo Sim - Seoul, KR
Nathanael Gray - Boston MA, US
Wenjun Zhou - Brighton MA, US
Jae Won Chang - San Diego CA, US
Jianming Zhang - Cambridge MA, US
Ellen Weisberg - Nashua NH, US

Assignee:

Dana-Farber Cancer Institute, Inc. - Boston MA

International Classification:

C07D 513/04

US Classification:

51425218, 546114, 514301, 544295, 544362, 51425304

Abstract:

The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.