James O Boothe

US Patent:

44043759, Sep 13, 1983

Filed:

Apr 12, 1982

Appl. No.:

6/367501

Inventors:

James H. Boothe - Montvale NJ
Adma S. Ross - Suffern NY

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

C07D50136
A61K 31545

US Classification:

544 27

Abstract:

7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R. sub. 2 is selected from the group hydrogen, amino, C. sub. 1 to C. sub. 6 alkylamino and di-C. sub. 1 to C. sub. 6 alkylamino and R. sub. 3, R. sub. 4 and R. sub. 5 are the same or different and are selected from the group hydrogen, hydroxy, C. sub. 1 to C. sub. 6 alkyl, C. sub. 1 to C. sub. 6 alkoxy, trifluoromethyl, phenyl, substituted phenyl, heterocyclic aryl, and R. sub. 3 and R. sub. 4 or R. sub. 4 and R. sub. 5 taken together are the moiety --CH. sub. 2 (CH. sub. 2). sub. 2 CH. sub. 2 --.

US Patent:

44043740, Sep 13, 1983

Filed:

Apr 12, 1982

Appl. No.:

6/367502

Inventors:

James H. Boothe - Montvale NJ
Adma S. Ross - Suffern NY

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

C07D50136
A61K 31545

US Classification:

544 26

Abstract:

7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R. sub. 2 is selected from the group hydrogen, amino, C. sub. 1 to C. sub. 6 alkylamino and di-C. sub. 1 to C. sub. 6 alkylamino and R. sub. 3, R. sub. 4 and R. sub. 5 are the same or different and are selected from the group hydrogen, hydroxy, C. sub. 1 to C. sub. 6 alkyl, C. sub. 1 to C. sub. 6 alkoxy, trifluoromethyl, phenyl, substituted phenyl, heterocyclic aryl, and R. sub. 3 and R. sub. 4 or R. sub. 4 and R. sub. 5 taken together are the moiety --CH. sub. 2 (CH. sub. 2). sub. 2 CH. sub. 2 --.

US Patent:

43177743, Mar 2, 1982

Filed:

Mar 24, 1978

Appl. No.:

5/889675

Inventors:

Martin L. Sassiver - Monsey NY
James H. Boothe - Montvale NJ

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

C07D49970

US Classification:

2602391

Abstract:

This disclosure describes compounds of the class of 6-[D-. alpha. -(substituted-coumarin-3-carboxamido)phenylacetamido]penicilla nic acids which possess antimicrobial activity.

US Patent:

44543360, Jun 12, 1984

Filed:

Sep 27, 1982

Appl. No.:

6/424825

Inventors:

William V. Curran - Pearl River NY
Martin L. Sassiver - Monsey NY
James H. Boothe - Montvale NJ

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

C07C14706
C07C14920
C07C149437
C07D28506

US Classification:

560 13

Abstract:

This disclosure describes a novel process for the synthesis of 5-mercapto-1,2,3-thiadiazoles which are useful as intermediates in the preparation of antibacterial agents.

US Patent:

43417035, Jul 27, 1982

Filed:

Sep 23, 1981

Appl. No.:

6/304727

Inventors:

Martin L. Sassiver - Monsey NY
James H. Boothe - Montvale NJ

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

C07D49970

US Classification:

2602391

Abstract:

This disclosure describes compounds of the class of 6-[D-. alpha. -(benzocoumarin-3-carboxamido)phenylacetamido] penicillanic acids which possess antimicrobial activity.

US Patent:

43439381, Aug 10, 1982

Filed:

Sep 23, 1981

Appl. No.:

6/304757

Inventors:

Martin L. Sassiver - Monsey NY
James H. Boothe - Montvale NJ

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

C07D50156

US Classification:

544 27

Abstract:

This disclosure describes compounds of the class of 6-[D-. alpha. -(substituted-coumarin-3-carboxamido)phenylacetamido ]penicillanic acids which possess antimicrobial activity.

US Patent:

44043767, Sep 13, 1983

Filed:

Apr 12, 1982

Appl. No.:

6/367503

Inventors:

James H. Boothe - Montvale NJ
Adma S. Ross - Suffern NY

Assignee:

American Cyanamid Company - Stamford CT

International Classification:

C07D50136
A61K 31545

US Classification:

544 27

Abstract:

7-acetamidocephalosporins are disclosed herein which are substituted at position 3 of the cephalosporin nucleus with the group ##STR1## wherein R. sub. 2 is selected from the group hydrogen, amino, C. sub. 1 to C. sub. 6 alkylamino and di-C. sub. 1 to C. sub. 6 alkylamino and R. sub. 3, R. sub. 4 and R. sub. 5 are the same or different and are selected from the group hydrogen, hydroxy, C. sub. 1 to C. sub. 6 alkyl, C. sub. 1 to C. sub. 6 alkoxy, trifluoromethyl, phenyl, substituted phenyl, heterocyclic aryl, and R. sub. 3 and R. sub. 4 or R. sub. 4 and R. sub. 5 taken together are the moiety --CH. sub. 2 (CH. sub. 2). sub. 2 CH. sub. 2 --.