James Albert Schaeffer

US Patent:

6531314, Mar 11, 2003

Filed:

Jun 3, 1998

Appl. No.:

09/077674

Inventors:

Joseph P. Arena - Eagleville PA
Doris F. Cully - Scotch Plains NJ
Scott D. Feighner - Highlands NJ
Andrew D. Howard - Park Ridge NJ
Paul A. Liberator - Holmdel NJ
James M. Schaeffer - Westfield NJ
Leonardus H. T. Van Der Ploeg - Scotch Plains NJ

Assignee:

Merck Co., Inc. - Rahway NJ

International Classification:

C12N 1500

US Classification:

435325, 536 231, 536 235, 530350, 435 691, 4353201

Abstract:

Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.

US Patent:

20030166144, Sep 4, 2003

Filed:

Nov 25, 2002

Appl. No.:

10/303204

Inventors:

Joseph Arena - Eagleville PA, US
Doris Cully - Scotch Plains NJ, US
Scott Feighner - Highlands NJ, US
Andrew Howard - Park Ridge NJ, US
Paul Liberator - Holmdel NJ, US
James Schaeffer - Westfield NJ, US
Leonardus Van Der Ploeg - Scotch Plains NJ, US

Assignee:

Merck & Co., Inc. - Rahway NJ

International Classification:

C12P021/02
C07K014/72
C07H021/04
C12N005/06

US Classification:

435/069100, 435/320100, 435/353000, 530/350000, 536/023500

Abstract:

Human, swine and rat growth hormone secretagogue receptors have been isolated, cloned and sequenced. Growth hormone secretagogue receptors are new members of the G-protein family of receptors. The growth hormone secretagogue receptors may be used to screen and identify compounds which bind to the growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and recovering from hip fracture and osteoporosis.

US Patent:

46650229, May 12, 1987

Filed:

Feb 17, 1984

Appl. No.:

6/581242

Inventors:

James M. Schaeffer - San Diego CA
Aaron J. Hsueh - San Diego CA

Assignee:

The Regents of the University of California - Berkeley CA

International Classification:

G01N 3353
G01N 33566
G01N 33536
G01N 33532

US Classification:

435 7

Abstract:

Reagent for immunoassay, ligand binding assay and ligand receptor assay in which luciferin is covalently bonded to a molecule having biological activity for bonding to a particular biologically active group of a material and method in which the luciferin and biologically active molecule conjugate is added to a material having a group for combination with the biological activity of the conjugated molecule, the mixture is incubated to bond the material to the reagent through the biological activity and the product of the bonding is reacted with luciferase to produce bioluminescence having intensity dependent on the concentration of the material being assayed.