Janet M Clark

US Patent:

20050130203, Jun 16, 2005

Filed:

Nov 4, 2004

Appl. No.:

10/983198

Inventors:

Qingyun Liu - North Wales PA, US
Terrence McDonald - Langhorne PA, US
Timothy Bonnert - Hartfordshire, GB
Gordon Ng - Point-Claire, CA
Lee Kolakowski - Timonium MD, US
Janet Clark - Bethesda MD, US
Tom Bonner - Bethesda MD, US

International Classification:

C12Q001/68
C07H021/04
C07K014/705

US Classification:

435006000, 435069100, 435320100, 435325000, 530350000, 536023500

Abstract:

DNA encoding a novel human GABAreceptor subunit, HG20, as well as the protein encoded by the DNA, is provided. Also provided is DNA encoding a novel murine GABAreceptor subunit, GABAR1a, as well as the protein encoded by the DNA. Heterodimers of HG20 protein and GABAR1a protein that form a functional GABAreceptor are disclosed. Methods of identifying agonists and antagonists of the GABAreceptor are also provided.

US Patent:

20100040552, Feb 18, 2010

Filed:

Oct 14, 2009

Appl. No.:

12/579230

Inventors:

David J. Stone - Wyncote PA, US
Janet E. Clark - Matawan NJ, US

Assignee:

ROSETTA INPHARMATICS LLC - Seattle WA
MERCK & CO., INC. - Rahway NJ

International Classification:

A61K 49/00
G01N 33/53
A61P 29/00

US Classification:

424 92, 435 721

Abstract:

The present invention provides methods for identifying a modulator of glucocorticoid receptor activity. In one embodiment, the methods include the steps of (a) contacting neuron-like cells, in vitro, with a chemical agent; (b) measuring the expression of a member, or group of members, of a group of genes (as defined herein) in the neuron-like cells contacted with the chemical agent; and (c) determining whether the chemical agent significantly alters the expression of the member, or group of members, of the group of genes, thereby determining whether the chemical agent is likely to be a modulator of glucocorticoid receptor activity. In another embodiment, an in vivo method for identifying a modulator of glucocorticoid receptor activity is provided.