Janet M Davis

US Patent:

8623648, Jan 7, 2014

Filed:

Apr 24, 2008

Appl. No.:

12/108852

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US

Assignee:

Janssen Biotech, Inc. - Horsham PA

International Classification:

A01N 61/00
C12N 5/00
C12N 5/02
C12N 5/08

US Classification:

435377, 435325, 435366, 514 1

Abstract:

The present invention is directed to methods to treat pluripotent cells, whereby the pluripotent cells can be efficiently expanded in culture and differentiated by treating the pluripotent cells with an inhibitor of GSK-3B enzyme activity.

US Patent:

20060153894, Jul 13, 2006

Filed:

Jun 29, 2005

Appl. No.:

11/170410

Inventors:

Ragae Ghabrial - Helmetta NJ, US
Ramie Fung - Flemington NJ, US
Alireza Rezania - Hillsborough NJ, US
Janet Davis - Branchburg NJ, US

International Classification:

A61K 38/18
A61F 2/00

US Classification:

424426000, 514002000

Abstract:

This invention provides devices designed to effectively deliver multiple biological entities in combination for tissue engineering. In particular, the present invention provides devices capable of delivering cells or clusters of cells, such as islets of Langerhans, in combination with a therapeutic compound, such as an angiogenic growth factor, for the purpose of transplantation. The devices of the present invention are composed of at least two compartments that are designed independently and processed separately in order to accommodate different requirements of the biological entities. The compartments of the present device can be combined prior to or at the time of implantation, such that the therapeutic released from one compartment provides some benefit to cells hosted by another compartment to promote or improve their proliferation, differentiation, survival, or functionality.

US Patent:

20070202145, Aug 30, 2007

Filed:

Dec 31, 2003

Appl. No.:

10/749192

Inventors:

Ragae Ghabrial - Helmetta NJ, US
Janet Davis - Branchburg NJ, US

International Classification:

A61F 2/02
A61K 38/18
A61K 38/22
A61K 35/12
A61K 39/395
A61K 31/203

US Classification:

424423000, 424093700, 514012000, 514559000, 424130100

Abstract:

This idea represents a method for incorporation of a therapeutic molecule, preferably a protein or a growth factor, into a biodegradable scaffold, specifically one that is made of a foam nonwoven composite. The process utilizes a solvent preferably tertiary butanol to facilitate the infiltration of the particles of the therapeutic agent into the porous matrix of the scaffold. In the case of small molecules, such as a p38 kinase inhibitor, the drug is dissolved directly in sterile filtered t-butanol and a given amount is pipetted aseptically onto the pre-sterilized scaffold. The solution is readily adsorbed into the polymer matrix. The solution is readily frozen to allow minimal interaction with the polymer scaffold thereby protecting the scaffold's internal matrix. The solvent is then aseptically removed by lyophilization.

US Patent:

20070264269, Nov 15, 2007

Filed:

Dec 15, 2006

Appl. No.:

11/611602

Inventors:

Alexander Harmon - Clinton NJ, US
Janet Davis - Branchburg NJ, US

Assignee:

Ethicon, Incorporated - Sommerville NJ

International Classification:

A61K 39/00

US Classification:

424184100

Abstract:

Cell-based compositions and methods of their use to inhibit an adverse immune response such as graft versus host disease or rejection of transplanted tissue in a transplant recipient that is histocompatibility mismatched to the transplant donor are disclosed. The compositions and methods utilize postpartum-derived cells, such as cells derived from the placenta or umbilicus.

US Patent:

20080063628, Mar 13, 2008

Filed:

Sep 11, 2006

Appl. No.:

11/530622

Inventors:

Janet E. Davis - Branchburg NJ, US
Ramie Fung - Flemington NJ, US

International Classification:

A61K 35/12
C12N 5/02

US Classification:

424 937, 435377

Abstract:

A method for promoting the differentiation of cells by contacting cells with a chromatin-remodeling agent to increase the expression of a transcriptional regulator.

US Patent:

20100015711, Jan 21, 2010

Filed:

Jun 30, 2009

Appl. No.:

12/494789

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US
Christine Parmenter - Skillman NJ, US
Pascal Ghislain André Bonnet - Beerse, BE

International Classification:

C12N 5/00

US Classification:

435377

Abstract:

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage comprising culturing the pluripotent stem cells in medium comprising a sufficient amount of GDF-8 to cause the differentiation of the pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

US Patent:

20110091971, Apr 21, 2011

Filed:

Jun 29, 2009

Appl. No.:

12/493741

Inventors:

Janet Davis - Skillman NJ, US
Jiajian Liu - Skillman NJ, US
Gopalan Raghunathan - San Diego CA, US
Michael Joseph Hunter - San Diego CA, US
Jose Pardinas - San Diego CA, US
Judith Ann Connor - San Diego CA, US
Ronald Vernon Swanson - San Diego CA, US
Ellen Chi - San Diego CA, US

International Classification:

C12N 5/0735
C12N 5/071

US Classification:

435377

Abstract:

The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention is directed to methods and compositions to differentiate pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage. The present invention also provides methods to generate and purify agents capable of differentiating pluripotent stem cells into cells expressing markers characteristic of the definitive endoderm lineage.

US Patent:

20110151561, Jun 23, 2011

Filed:

Dec 16, 2010

Appl. No.:

12/970365

Inventors:

JANET DAVIS - SKILLMAN NJ, US
CHRISTINE PARMENTER - SKILLMAN NJ, US
KEVIN DITOLVO - SKILLMAN NJ, US

International Classification:

C12N 5/071

US Classification:

435377

Abstract:

The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to increase the expression of NGN3 and NKX6.1 in populations of cells expressing markers characteristic of the pancreatic endocrine lineage.