Brent S. Gaylord - San Diego CA, US Jean M. Wheeler - San Diego CA, US Glenn P. Bartholomew - San Diego CA, US Frank Peter Uckert - Buellton CA, US Janice W. Hong - San Diego CA, US William H. Huisman - San Diego CA, US Yongchao Liang - Irvine CA, US
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
Reagents For Directed Biomarker Signal Amplification
Brent S. Gaylord - San Diego CA, US Jean M. Wheeler - San Diego CA, US Glenn P. Bartholomew - San Diego CA, US Frank Peter Uckert - Buellton CA, US Janice W. Hong - San Diego CA, US William H. Huisman - San Diego CA, US
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
Reagents For Directed Biomarker Signal Amplification
Brent S. Gaylord - San Diego CA, US Jean M. Wheeler - San Diego CA, US Glenn P. Bartholomew - San Diego CA, US Yongchao Liang - Irvine CA, US Janice W. Hong - San Diego CA, US William H. Huisman - San Diego CA, US Frank Peter Uckert - Buellton CA, US Lan T. Tran - Rosemead CA, US Adrian Charles Vernon Palmer - Rottingdean, GB Trung Nguyen - San Diego CA, US Russell A. Baldocchi - Encinitas CA, US
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
Signal Amplified Biological Detection With Conjugated Polymers
Bin Liu - Singapore, SG Chun Wang - Singapore, SG Ruoyu Zhan - Singapore, SG Glenn P. Bartholomew - San Diego CA, US Janice W. Hong - San Diego CA, US Jean M. Wheeler - San Diego CA, US Brent S. Gaylord - San Diego CA, US
International Classification:
C08G 65/00
US Classification:
525451, 528392, 528205, 525534
Abstract:
The devices and method are provided for detecting labeled and label-free analytes, such as nucleic acids and proteins, employing conjugated cationic, anionic and neutral polymers. The analytes can be immobilized on a solid support material. The solid support material can be disposed in the pre-fabricated patterns on a substrate. The chemical structures of the polymers employed by the various embodiments of the present invention are described herein.
Reagents For Directed Biomarker Signal Amplification
- BERKSHIRE, GB Glenn P. Bartholomew - Escondido CA, US Russell A. Baldocchi - Encinitas CA, US Janice W. Hong - San Diego CA, US William H. Huisman - San Diego CA, US Yongchao Liang - Irvine CA, US Trung Nguyen - San Diego CA, US Lan T. Tran - Oceanside CA, US Jean M. Wheeler - San Diego CA, US Adrian Charles Vernon Palmer - Brighton, GB Frank Peter Uckert - San Diego CA, US
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
Novel Reagents For Directed Biomarker Signal Amplification
- BERKSHIRE, GB Glenn P. Bartholomew - Escondido CA, US Russell A. Baldocchi - Encinitas CA, US Janice W. Hong - San Diego CA, US William H. Huisman - San Diego CA, US Yongchao Liang - Irvine CA, US Trung Nguyen - San Diego CA, US Lan T. Tran - Oceanside CA, US Jean M. Wheeler - San Diego CA, US Adrian Charles Vernon Palmer - Brighton, GB Frank Peter Uckert - San Diego CA, US
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
Novel Reagents For Directed Biomarker Signal Amplification
- BERKSHIRE, GB Glenn P. Bartholomew - Escondido CA, US Russell A. Baldocchi - Encinitas CA, US Janice W. Hong - San Diego CA, US William H. Huisman - San Diego CA, US Yongchao Liang - Irvine CA, US Trung Nguyen - San Diego CA, US Lan T. Tran - Oceanside CA, US Jean M. Wheeler - San Diego CA, US Adrian Charles Vernon Palmer - Brighton, GB Frank Peter Uckert - San Diego CA, US
Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.
Fluorescent Methods And Materials For Directed Biomarker Signal Amplification
- Berkshire, GB Janice W. Hong - San Diego CA, US ChengJun Sun - Goleta CA, US Russell A. Baldocchi - Encinitas CA, US
International Classification:
G01N 33/58 G01N 33/542 C08G 61/02 C08G 61/12
Abstract:
Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.
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