Janice W Hong

US Patent:

7232913, Jun 19, 2007

Filed:

Sep 28, 2004

Appl. No.:

10/952624

Inventors:

Guillermo C. Bazan - Santa Barbara CA, US
Bernhard Koehler - Seligenstadt, DE
Hadjar Benmansour - Hyeíg, FR
Janice W. Hong - Santa Barbara CA, US
Han Young Woo - Goleta CA, US
Alexander Mikhailovsky - Ventura CA, US
Hideki Gorohmaru - Yokohama, JP
Shuuichi Maeda - Yokohama, JP
T. Kojima - Yokohama, JP
Motoyuki Shigeiwa - Yokohama, JP

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

C07D 209/94
C07D 209/82
C07C 211/64
C07C 211/54
G02B 5/02
G02F 1/361

US Classification:

548439, 548444, 252582, 564434, 564282

Abstract:

Chromophores having two-photon or other multi-photon absorptivity. The chromophores are based on a structure of four stilbenoid groups attached to a paracyclophane core, where each stilbenoid group comprises a nitrogen-containing organic group attached by its nitrogen atom to a stilbenoid arm. In particular embodiments, at least one of the stilbenoid groups includes a sulfonium, ammonium, selenium, iodonium or phosphonium moiety. The chromophores have utility as photo-polymerization initiators and two-photon fluorophores for biological imaging.

US Patent:

8158444, Apr 17, 2012

Filed:

Oct 8, 2007

Appl. No.:

11/868870

Inventors:

Brent S. Gaylord - Santa Barbara CA, US
Janice W. Hong - Santa Barbara CA, US
Russell Baldocchi - Santa Barbara CA, US

Assignee:

Sirigen, Inc.

International Classification:

G01N 33/533
G01N 21/76
G01N 33/53

US Classification:

436546, 436 56, 436172, 435 71

Abstract:

Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

US Patent:

8354239, Jan 15, 2013

Filed:

Aug 1, 2011

Appl. No.:

13/195736

Inventors:

Brent S. Gaylord - Santa Barbara CA, US
Janice W. Hong - Santa Barbara CA, US
Russell Baldocchi - Santa Barbara CA, US

Assignee:

Sirigen, Inc. - San Diego CA

International Classification:

G01N 33/53
G01N 33/533
G01N 21/76

US Classification:

435 71, 436546, 436 56, 436172

Abstract:

Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.

US Patent:

8362193, Jan 29, 2013

Filed:

Mar 17, 2011

Appl. No.:

13/065315

Inventors:

Brent S. Gaylord - San Diego CA, US
Jean M. Wheeler - San Diego CA, US
Glenn P. Bartholomew - San Diego CA, US
Frank Peter Uckert - Buellton CA, US
Janice W. Hong - San Diego CA, US
William H. Huisman - San Diego CA, US
Yongchao Liang - Irvine CA, US

Assignee:

Sirigen Group Limited - Hampshire

International Classification:

C08G 65/34
C08G 64/22
C08G 64/42
C08G 65/00
C08G 64/00

US Classification:

528371, 528288, 528370, 528 8, 528425, 564156, 435 71, 4352871, 424 9411

Abstract:

Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

US Patent:

8455613, Jun 4, 2013

Filed:

Mar 17, 2011

Appl. No.:

13/065268

Inventors:

Brent S. Gaylord - San Diego CA, US
Jean M. Wheeler - San Diego CA, US
Glenn P. Bartholomew - San Diego CA, US
Frank Peter Uckert - Buellton CA, US
Janice W. Hong - San Diego CA, US
William H. Huisman - San Diego CA, US

Assignee:

Sirigen Group Limited - Hampshire

International Classification:

C08G 65/34
C08G 64/22
C08G 64/42
C08G 65/00
C08G 64/00

US Classification:

528371, 528288, 528370, 528 8, 528425, 564156, 435 71, 4352871, 424 9411

Abstract:

Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

US Patent:

8575303, Nov 5, 2013

Filed:

Jan 19, 2011

Appl. No.:

13/009764

Inventors:

Brent S. Gaylord - San Diego CA, US
Jean M. Wheeler - San Diego CA, US
Glenn P. Bartholomew - San Diego CA, US
Yongchao Liang - Irvine CA, US
Janice W. Hong - San Diego CA, US
William H. Huisman - San Diego CA, US
Frank Peter Uckert - Buellton CA, US
Lan T. Tran - Rosemead CA, US
Adrian Charles Vernon Palmer - Rottingdean, GB
Trung Nguyen - San Diego CA, US
Russell A. Baldocchi - Encinitas CA, US

Assignee:

Sirigen Group Limited - Hampshire

International Classification:

C08G 65/34
C08G 64/22
C08G 64/42
C08G 65/00
C08G 64/00

US Classification:

528371, 528288, 528370, 528 8, 528425, 564156, 435 71, 4352871, 424 9411

Abstract:

Described herein are methods, compositions and articles of manufacture involving neutral conjugated polymers including methods for synthesis of neutral conjugated water-soluble polymers with linkers along the polymer main chain structure and terminal end capping units. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

US Patent:

20040192968, Sep 30, 2004

Filed:

Mar 15, 2004

Appl. No.:

10/801963

Inventors:

Guillermo Bazan - Santa Barbara CA, US
Bernhard Koehler - Seligenstadt, DE
Alexander Mikhailovsky - Ventura CA, US
Hadjar Benmansour - Goleta CA, US
Bin Liu - Goleta CA, US
Janice Hong - Santa Barbara CA, US

International Classification:

C07C251/16

US Classification:

564/273000

Abstract:

Two-photon or multi-photon chromophores having a conjugated pi-electron system with donating groups at each end of the pi-electron system providing charge-transfer properties, and having quaternary amine groups that can enhance the solubility of the chromophore in water. In a particular embodiment, the chromophore is based on a distyrylbenzene core, with donor or acceptor groups attached to the central benzene ring.

US Patent:

20120028828, Feb 2, 2012

Filed:

Aug 1, 2011

Appl. No.:

13/195747

Inventors:

Brent S. Gaylord - Santa Barbara CA, US
Janice W. Hong - Santa Barbara CA, US
Russell Baldocchi - Santa Barbara CA, US

Assignee:

SIRIGEN INC. - San Diego CA

International Classification:

C40B 30/04
G01N 33/53
C08G 73/06

US Classification:

506 9, 525389, 435 794

Abstract:

Methods and compositions are provided that include a multichromophore and/or multichromophore complex for identifying a target biomolecule. A sensor biomolecule, for example, an antibody can be covalently linked to the multichromophore. Additionally, a signaling chromophore can be covalently linked to the multichromophore. The arrangement is such that the signaling chromophore is capable of receiving energy from the multichromophore upon excitation of the multichromophore. Since the sensor biomolecule is capable of interacting with the target biomolecule, the multichromophore and/or multichromophore complex can provide enhanced detection signals for a target biomolecule.