Jason E Simon

US Patent:

7338772, Mar 4, 2008

Filed:

Apr 10, 2003

Appl. No.:

10/411545

Inventors:

Ying Jiang - Scotch Plains NJ, US
Fang Liang Zhang - Fanwood NJ, US
Nicholas J. Murgolo - Millington NJ, US
Lin Luo - Edison NJ, US
Jason S. Simon - Westfield NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

G01N 33/566

US Classification:

435 721, 435 72, 436501

Abstract:

The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention also relates to methods for modulating a G-protein coupled receptor and for identifying substances which modulate the receptor.

US Patent:

7807390, Oct 5, 2010

Filed:

Jan 7, 2008

Appl. No.:

11/970276

Inventors:

Ying Jiang - Scotch Plains NJ, US
Fang Liang Zhang - Fanwood NJ, US
Nicholas J. Murgolo - Millington NJ, US
Lin Luo - Edison NJ, US
Jason S. Simon - Westfield NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

G01N 33/566
C07K 14/705

US Classification:

435 721, 435 71, 435 72, 436501

Abstract:

The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention also relates to methods for modulating a G-protein coupled receptor and for identifying substances which modulate the receptor.

US Patent:

8133980, Mar 13, 2012

Filed:

Oct 1, 2010

Appl. No.:

12/896297

Inventors:

Ying Jiang - Scotch Plains NJ, US
Fang Liang Zhang - Fanwood NJ, US
Nicholas J. Murgolo - Millington NJ, US
Lin Luo - Edison NJ, US
Jason S. Simon - Westfield NJ, US

Assignee:

Schering Corporation - Kenilworth NJ

International Classification:

C07K 16/00
C12P 21/08

US Classification:

5303879, 5303881, 53038815, 4241391

Abstract:

The present invention relates to RF-amide peptides and their use for treating, preventing and curing neurological and metabolic medical disorders. The invention also relates to methods for modulating a G-protein coupled receptor and for identifying substances which modulate the receptor.

US Patent:

20090192135, Jul 30, 2009

Filed:

Mar 28, 2006

Appl. No.:

11/887346

Inventors:

Jason Samuel Simon - Westfield NJ, US
Maha Chabhar Karnoub - Doylestown PA, US
Michael E. Severino - Westlake Village CA, US
David James Devlin - New City NY, US
Andrew Stewart Plump - Westfield NJ, US
Eric E. Schadt - Kirkland WA, US

Assignee:

SCHERING CORPORATION - Kenilworth NJ
MERCK & CO., INC. - Rahway NJ
ROSETTA INPHARMATICS LLC - Seattle WA

International Classification:

A61K 31/397
C12Q 1/60
C12Q 1/68
C40B 30/04
C07H 21/04

US Classification:

51421002, 435 11, 435 6, 506 9, 536 235

Abstract:

The present invention relates to the identification and use of single nucleotide polymorphisms and haplotypes in the Niemann Pick C1-Like 1 (NPC1L1) gene. In particular, methods are provided for correlating NPC1L1 polymorphisms and haplo-types with the responsiveness of a pharmaceutically active compound administered to a human subject. The invention further relates to a method for estimating the responsiveness of a pharmaceutically active compound administered to a human subject which method comprises determining at least one polymorphism in the NPC1L1 gene. The methods are based on determining polymorphisms in the NPC1L1 gene and correlating the responsiveness of a pharmaceutically active compound in the human by reference to one or more polymorphism in NPC1L1. The invention further relates to isolated nucleic acids comprising within their sequence the polymorphisms as defined herein, to nucleic acid primers and oligonucleotide probes capable of hybridizing to such nucleic acids and to a diagnostic kit comprising one or more of such primers and probes for detecting a polymorphism in the NPC1L1 gene.

US Patent:

20110158944, Jun 30, 2011

Filed:

Nov 26, 2008

Appl. No.:

12/745031

Inventors:

Thomas J. Hosted - Summit NJ, US
Jason S. Simon - Westfield NJ, US
Marc M. Delorenzo - East Hanover NJ, US
Donna Marie Carr - Kenilworth NJ, US
William T. Windsor - East Brunswick NJ, US
Ahmed A. Samatar - West Windsor NJ, US

International Classification:

A61K 38/21
C12Q 1/68
A61P 35/00

US Classification:

424 857, 435 612

Abstract:

The present invention provides, inter alia, methods for predicting the sensitivity of a disease, such as cancer, to an ERK1 or ERK2 or MEK inhibitor by detecting the presence of an allele of BRAF in cells mediating the disease. Methods of treatment are also provided.

Address:

7675 Phoenix Dr APT 429, Houston, TX 77030

Phone:

(281)4125801

VIN:

1G1YY26U775117503

Make:

CHEVROLET

Model:

CORVETTE

Year:

2007