Randy R. Robinson - Los Angeles CA Alvin Y. Liu - Santa Monica CA Jeffrey A. Ledbetter - Seattle WA
Assignee:
XOMA Corporation - Berkeley CA
International Classification:
A61K 39395 C07K 1630 G01N 33574
US Classification:
435 723
Abstract:
The present invention relates to a chimeric IgG1 antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a human constant region and a variable region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention also relates to the increased ADCC and CDC cytolytic activities of the chimeric antibody, methods of production by recombinant DNA techniques, and uses.