Jeffrey Lee Ledbetter

US Patent:

20010053361, Dec 20, 2001

Filed:

Jun 7, 1995

Appl. No.:

08/476818

Inventors:

CRAIG B. THOMPSON - ANN ARBOR MI, US
CARL H. JUNE - ROCKVILLE MD, US
JEFFREY A. LEDBETTER - SEATTLE WA, US
TULLIA LINDSTEN - ANN ARBOR MI, US

Assignee:

THE REGENTS OF THE UNIVERSITY OF MICHIGAN

International Classification:

A61K039/395
A01N063/00
C12N005/00

US Classification:

424/143100, 424/093100, 424/093700, 424/093710, 435/375000, 435/377000

Abstract:

A method of immunotherapy stimulates the T cell CD28 surface molecule to enhance T cell proliferation and increase overall lymphokine levels or to increase cellular production of human T1 lymphokines or both. Thee method is selective for the induction of activated T cell mediated immune responses and enhances immune function even in the presence of immunosuppresants.

US Patent:

20030157102, Aug 21, 2003

Filed:

Mar 13, 2002

Appl. No.:

10/099001

Inventors:

Craig Thompson - Ann Arbor MI, US
Carl June - Rockville MD, US
Jeffrey Ledbetter - Seattle WA, US
Tullia Lindsten - Ann Arbor MI, US

Assignee:

The Regents of the University of Michigan

International Classification:

A61K039/395
C12P021/04

US Classification:

424/144100, 435/070210

Abstract:

A method of immunotherapy stimulates the T cell CD28 surface molecule to enhance T cell proliferation and increase overall lymphokine levels or to increase cellular production of human T1 lymphokines or both. The method is selective for the induction of activated T cell mediated immune responses and enhances immune function even in the presence of immunosuppresants.