Jeffrey M Ledbetter

US Patent:

6652852, Nov 25, 2003

Filed:

Nov 28, 2000

Appl. No.:

09/724138

Inventors:

Randy R. Robinson - Walnut Creek CA
Alvin Y. Liu - Seattle WA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

Royalty Pharma Finance Trust - Wilimington DE

International Classification:

A61K 39395

US Classification:

4241331, 4241531, 4241551, 4241781, 4241821, 4241831, 5303873, 53038873, 5303911, 5303913, 5303917

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

6893625, May 17, 2005

Filed:

Aug 1, 2000

Appl. No.:

09/630198

Inventors:

Randy R. Robinson - Mountain View CA, US
Alvin Y. Liu - Bellevue WA, US
Jeffrey A. Ledbetter - Seattle WA, US

Assignee:

Royalty Pharma Finance Trust - Wilmington DE

International Classification:

A61K039/00
C07K016/00

US Classification:

424 149, 424 934, 424 94, 4241331, 4241531, 4241551, 4241781, 4241811, 4241831, 5303873

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

20050163708, Jul 28, 2005

Filed:

Sep 15, 2004

Appl. No.:

10/941768

Inventors:

Randy Robinson - Walnut Creek CA, US
Alvin Liu - Seattle WA, US
Jeffrey Ledbetter - Seattle WA, US

International Classification:

A61K051/00
C07H021/04
C12P021/04
A61K039/395

US Classification:

424001490, 424009600, 435069100, 435328000, 435320100, 435252300, 530387300, 424133100, 536023530

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

20100330089, Dec 30, 2010

Filed:

Jun 12, 2008

Appl. No.:

12/664166

Inventors:

Nitin K. Damle - Upper Saddle River NJ, US
Lioudmila Tchistiakova - Andover MA, US
Kyriaki Dunussi-Joannopoulos - Belmont MA, US
Sandy Alexander Simon - Seattle WA, US
William Brady - Bothell WA, US
Laura Sue Grosmaire - Hobart WA, US
Jeffrey Alan Ledbetter - Shoreline WA, US

Assignee:

Wyeth - Madison NJ
Trubion Pharmaceuticals Inc. - Seattle WA

International Classification:

A61K 39/395
C07K 16/28
C07H 21/00
C12N 15/63
C12N 5/10
C12P 21/02
G01N 33/566
A61P 37/02
A61P 29/00
A61P 25/00
A61P 35/00

US Classification:

4241351, 5303873, 4241331, 536 2353, 4353201, 435328, 435 696, 435 724

Abstract:

The present invention provides materials and methods for treatment of diseases involving aberrant B-cell activity, using a CD20-specific binding molecule, in particular, antibodies or antigen binding fragment thereof. The compositions disclosed herein is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies and autoimmune diseases.

US Patent:

56771800, Oct 14, 1997

Filed:

Jun 6, 1995

Appl. No.:

8/469916

Inventors:

Randy R. Robinson - Walnut Creek CA
Alvin Y. Liu - Seattle WA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

Xoma Corporation - Berkeley CA

International Classification:

C12N 119
C12N 520
C12N 1513

US Classification:

435328

Abstract:

The present invention relates to a eukaryotic host cell that contains DNA encoding a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is also related to methods of producing the antibody.

US Patent:

61207675, Sep 19, 2000

Filed:

Feb 12, 1998

Appl. No.:

9/021934

Inventors:

Randy R. Robinson - Walnut Creek CA
Alvin Y. Liu - Seattle WA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

Pharmaceutical Royalties, L.L.C. - New York NY
Bioventure Investments, kft

International Classification:

A61K 39395
C07K 1630

US Classification:

4241331

Abstract:

A chimeric antibody with human constant region and murine variable region, having specificity to a 35 kDA polypeptide (Bp35(CD20)) expressed on the surface of human B cells, methods of production, and uses.

US Patent:

57211086, Feb 24, 1998

Filed:

Jun 6, 1995

Appl. No.:

8/471984

Inventors:

Randy R. Robinson - Walnut Creek CA
Alvin Y. Liu - Seattle WA
Jeffrey A. Ledbetter - Seattle WA

Assignee:

XOMA Corporation - Berkeley CA

International Classification:

A61K 33395
C07K 1630
G01N 33574

US Classification:

435 723

Abstract:

The present invention relates to a chimeric antibody molecule comprising two heavy chains and two light chains, each of the chains comprising a variable region and a human constant region, said antibody having specificity for the antigen bound by the 2H7 murine monoclonal antibody. The invention is also related to methods of use for such antibody.