Jeffrey Perlman

• Company:

  West Plano Diabetes and Endocrine Center, PA
• Address:

  6124 W Parker Rd Suite 332, Plano, TX 75093
• Phones:

  (972)9817812 (972)9817836

• School / High School:

  UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE

  1982

English

Healthgrades Honor Roll • Alpha Omega Alpha Medical Student Honor Society, 1981 • Merck Senior Fellow Award, 1995 • First Place Knoll Thyroid Research Award, 1995 • Fellow, American College of Endocrinology, 1995 • NIH Physician Scientist Award, 1992 • AMA Physician Recognition Award with Commendation, 2012 • International Society for Clinical Densitometry Certified Clinical Densitometrist, 2009 • Endocrinology, Third Edition, edited by Leslie J. deGroot Principles of Hormone Action, Second Messenger Signaling Pathways: Phosphatidylinositol and Calcium, 1995 • Laakkonen LJ, Guarnieri F, Perlman JH, Gershengorn MC, Osman R: A refined model of the thyrotrophin-releasing hormone (TRH) receptor binding pocket. Novel mixed mode Monte Carlo/stochastic dynamics simulations of the complex between TRH and TRH receptor. Biochemistry 1996 Jun 18; 35(24):7651-63 • Perlman JH, Colson AO, Jain R, Czyzewski B, Cohen LA, Osman R, Gershengorn MC: Role of the extracellular loops of the thyrotrophin-releasing hormone receptor: evidence for an initial interaction with thyrotrophin-releasing hormone. Biochemistry 1997 Dec 16; 36(50):15670-6 • Perlman JH, Gershengorn MC: Thyrotrophin-releasing hormone stimulation of phosphoinositide hydrolysis desensitizes. Evidence against mediation by protein kinase C or calcium. Endocrinology 1991 Nov; 129(5):2679-86 • Perlman JH, Thaw CN, Laakkonen L, Bowers CY, Osman R, Gershengorn MC: Hydrogen bonding interactions of thyrotrophin-releasing hormone (TRH) with transmembrane tyrosine 106 of the TRH receptor. J Biol Chem 1994; 269(3):1610-3 • Perlman JH, Colson AO, Wang W, Bence K, Osman R, Gershengorn MC: Interactions between conserved residues in transmembrane helices 1, 2, and 7 of the thyrotrophin-releasing hormone receptor. J Biol Chem 1997 May; 272(18):11937-42 • Chu W, Perlman JH, Gershengorn MC, Moeller KD: Thyrotrophin-releasing hormone analogs: a building block approach to the construction of tetracyclic peptidomimetics. Bioorg Med Chem Lett 1998 Nov 3; 8(21):3093-6 • Rutledge LD, Perlman JH, Gershengorn MC, Marshall GR, Moeller KD: Conformationally restricted TRH analogs: a probe for the pyroglutamate region. J Med Chem 1996 Apr 12; 39(8):1571-4 • Perlman JH, Laakkonen L, Osman R, Gershengorn MC: A model of the thyrotrophin-releasing hormone (TRH) receptor binding pocket. Evidence for a second direct interaction between transmembrane helix 3 and TRH. J Biol Chem 1994 Sep 23; 269(38):23383-6. • Colson AO, Perlman JH, Smolyar A, Gershengorn MC, Osman R: Static and dynamic roles of extracellular loops in G protein-coupled receptors: a mechanism for sequential binding of thyrotrophin-releasing hormone to its receptor. Biophys J 1998 Mar; 74(3):1087-1100 • Colson AO, Perlman JH, Jinsi-Parimoo A, Nussenzveig DR, Osman R, Gershengorn MC: A hydrophobic cluster between transmembrane helices 5 and 6 constrains the thyrotrophin-releasing hormone receptor in an inactive conformation. Mol Pharmacol 1998 Dec; 54(6):968-78 • Laakkonen L, Li W, Perlman JH, Guarnieri F, Osman R, Moeller KD, Gershengorn MC: Restricted analogs provide evidence of a biologically active conformation of thyrotrophin-releasing hormone. Mol Pharmacol 1996 Jun; 49(6):1092-6 • Perlman JH, Laakkonen LJ, Guarnieri F, Osman R, Gershengorn MC: A refined model of the thyrotrophin-releasing hormone (TRH) receptor binding pocket. Experimental analysis and energy minimization of the complex between TRH and TRH receptor. Biochemistry 1996 Jun 18; 35(24):7643-50 • Perlman JH, Nussenzveig DR, Osman R, Gershengorn MC: Thyrotrophin-releasing hormone binding to the mouse pituitary receptor does not involve ionic interactions. A model for neutral peptide binding to G protein-coupled receptors. J Biol Chem 1992 Dec 5; 267(34):24413-7 • Perlman JH, Laakkonen L, Thaw CN, Osman R, Gershengorn MC: Analysis of the role of transmembrane helix three of the thyrotrophin-releasing hormone (TRH) receptor in directly binding TRH. Trans Assoc Am Physicians 1993; 106:162-7. • Perlman JH, Laakkonen L, Osman R, Gershengorn MC: Distinct roles for arginines in transmembrane helices 6 and 7 of the thyrotrophin-releasing hormone receptor. Mol Pharmacol 1995 Mar; 47(3):480-4 • Jain R, Singh J, Perlman JH, Gershengorn MC: Synthesis and biology of new TRH analogues. Bioorg Med Chem 2002 Jan; 10(1):189-94 • Perlman JH, Wang W, Nussenzveig DR, Gershengorn MC: A disulfide bond between conserved extracellular cysteines in the thyrotrophin-releasing hormone receptor is critical for binding. J Biol Chem 1995 Oct 20; 270(42):24682-5 • Bucci E, Fronticelli C, Flanigan K, Perlman J, Steiner RF: Fluorescence anisotropy decay studies upon hemoglobin A and its subunits. Biopolymers 1979 May; 18(5):1261-76.

• Certificate:

  Diabetes, Metabolism & Endocrinology