Jian He

US Patent:

7713927, May 11, 2010

Filed:

Jan 15, 2008

Appl. No.:

12/014634

Inventors:

Jian He - Los Angeles CA, US
Randal H. Eckert - Ellensburg WA, US
Fengxia Qi - Laguna Niguel CA, US
Maxwell H. Anderson - Sequim WA, US
Wenyuan Shi - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA
C3 Jian, Inc. - Sequim WA

International Classification:

A61K 38/00

US Classification:

514 2

Abstract:

This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against a common oral pathogen and the causative agent of dental caries.

US Patent:

7846895, Dec 7, 2010

Filed:

Sep 6, 2007

Appl. No.:

11/851372

Inventors:

Randal H. Eckert - Ellensburg WA, US
Daniel K. Yarbrough - Los Angeles CA, US
Wenyuan Shi - Los Angeles CA, US
Maxwell H. Anderson - Sequim WA, US
Fengxia Qi - Laguna Niguel CA, US
Jian He - Los Angeles CA, US
Ian H. McHardy - Venice CA, US

Assignee:

The Regents of the University of California - Oakland CA
C3 Jian, Inc. - Inglewood CA

International Classification:

A61K 38/00
C07K 7/00

US Classification:

514 2, 514 12, 514 13, 530300, 530324, 424 169

Abstract:

The present invention relates to targeting peptides capable of specifically binding to microbial organisms (e. g. , or ), antimicrobial peptides having antimicrobial activities, and specifically/selectively targeted antimicrobial peptides (STAMPs). In addition, the present invention provides methods of selectively killing or inhibiting microbial organisms by using the peptides or compositions provided by the present invention.

US Patent:

8303962, Nov 6, 2012

Filed:

Jan 6, 2010

Appl. No.:

12/683188

Inventors:

Randal H. Eckert - Redondo Beach CA, US
Chris Kaplan - Los Angeles CA, US
Jian He - Los Angeles CA, US
Daniel K. Yarbrough - Los Angeles CA, US
Maxwell Anderson - Sequim WA, US
Jee-Hyun Sim - Garden Grove CA, US

Assignee:

C3 Jian, Inc. - Inglewood CA

International Classification:

A61K 38/00
A61K 38/04
A61K 39/00
A61K 39/02
A61K 39/09
A61K 39/38
C07K 4/00
C07K 5/00
C07K 7/00

US Classification:

4242441, 4241841, 4241851, 4241901, 4242341, 4242371, 4242821, 530300, 530326, 930 10, 930 20, 930 21, 930200

Abstract:

This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.

US Patent:

8389679, Mar 5, 2013

Filed:

Feb 5, 2010

Appl. No.:

12/701443

Inventors:

Randal H. Eckert - Redondo Beach CA, US
Daniel Yarbrough - Los Angeles CA, US
Wenyuan Shi - Los Angeles CA, US
Maxwell Anderson - Sequim WA, US
Jian He - Los Angeles CA, US
Chris Kaplan - Los Angeles CA, US
Jee-Hyun Sim - Garden Grove CA, US

Assignee:

The Regents of the University of California - Oakland CA

International Classification:

A61K 39/395

US Classification:

530324, 4241341, 435 34, 514 213

Abstract:

This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.

US Patent:

8609608, Dec 17, 2013

Filed:

Mar 24, 2010

Appl. No.:

12/730939

Inventors:

Jian He - Los Angeles CA, US
Randal H. Eckert - Ellensburg WA, US
Fengxia Qi - Laguna Niguel CA, US
Maxwell H. Anderson - Sequim WA, US
Wenyuan Shi - Los Angeles CA, US

Assignee:

C3 Jian, Inc. - Sequim WA
The Regents of the University of California - Oakland CA

International Classification:

A61K 38/10
A61K 38/04
A61K 38/16

US Classification:

514 26, 514 23, 514 24, 514 214, 514 215, 530324, 530325, 530326, 530327

Abstract:

This invention provides novel antimicrobial peptides that are effective to inhibit growth and/or proliferation of various gram positive bacteria. In particular, the peptides are effective against a common oral pathogen and the causative agent of dental caries.

US Patent:

20090098050, Apr 16, 2009

Filed:

Sep 27, 2006

Appl. No.:

12/066822

Inventors:

Daniel Yarbrough - Los Angeles CA, US
Wenyuan Shi - Los Angeles CA, US
Elizabeth Hagerman - Beverly Hills CA, US
Sotirios Tetradis - Culver City CA, US
Fengxia Qi - Laguna Niguel CA, US
Jian He - Los Angeles CA, US
Bruce Rutherford - Seattle WA, US
Randal Eckert - Ellensburg WA, US
Ben Wu - San Marino CA, US

Assignee:

THE REGENTS OF THE UNVERSITY OF CALIFORNIA - Oakland CA

International Classification:

A61K 49/00
C07K 7/00
A61K 38/04
A61K 38/05
A61K 38/07
A61K 38/08
A61K 38/10
A61K 38/16

US Classification:

424 91, 530331, 530330, 530329, 530328, 530327, 530326, 530325, 530324, 514 18, 514 19, 514 17, 514 16, 514 15, 514 14, 514 13, 514 12

Abstract:

Disclosed herein are a class of compounds comprising peptides of the sequence (X-Y-Z), wherein X is an amino acid selected from aspartic acid, glutamic acid, asparagine, alanine and glutamine, and Y and Z are amino acids selected from alanine, serine, threonine, phosphoserine, phosphothreonine, and their derivatives. These compounds have the property of binding tightly and specifically to calcified surfaces, making them useful for a variety of applications including remineralization of tooth and bone surfaces, diagnosis of bone and tooth defects, treatment of bone and tooth defects, and analysis of the presence and location of calcified deposits both in vitro and in vivo and in industrial, synthetic, medical, dental, and research applications where identification, localization, or manipulation of calcification is desirable.

US Patent:

20090298707, Dec 3, 2009

Filed:

Mar 18, 2009

Appl. No.:

12/406856

Inventors:

Daniel K. Yarbrough - Los Angeles CA, US
Randal H. Eckert - Redondo Beach CA, US
Ben Wu - San Marino CA, US
Elizabeth M. Hagerman - Beverly Hills CA, US
Wenyuan Shi - Los Angeles CA, US
Maxwell H. Anderson - Sequim WA, US
Fengxia Qi - Edmond OK, US
Jian He - Los Angeles CA, US

Assignee:

The Regents of the University of California - Oakland CA
C3 Jian, Inc. - Ingelwood CA

International Classification:

C40B 30/04
C40B 40/12
C40B 40/10
C40B 40/14
C40B 40/02
C40B 50/06
C07K 7/00

US Classification:

506 9, 506 19, 506 18, 506 20, 506 14, 506 26, 530328

Abstract:

In certain embodiments, this invention pertains to the creation of “Sparse Matrix” libraries of compounds. The sparse matrix libraries of this invention typically span an n-dimensional parameter (property) space at extremely sparse intervals and thereby provide a relatively small library of compounds (e.g., a library of about 200 or fewer compounds) that can be used to quickly and efficiently screen the compound parameter space for one or more desired physical, chemical, or biological properties (e.g., binding specificity, binding avidity, γtoxicity, solubility, mobility, cell permeability, serum half-life, biocompatibility, etc.).

US Patent:

20100184683, Jul 22, 2010

Filed:

Jan 6, 2010

Appl. No.:

12/683258

Inventors:

RANDAL H. ECKERT - Redondo Beach CA, US
CHRIS KAPLAN - Los Angeles CA, US
JIAN HE - Los Angeles CA, US
DANIEL K. YARBROUGH - Los Angeles CA, US
MAXWELL ANDERSON - Sequim WA, US
JEE-HYUN SIM - Garden Grove CA, US

Assignee:

C3 JIAN, INC. - Inglewood CA

International Classification:

A61K 38/16
C07K 14/00
C07K 7/08
C07K 7/06
A61K 38/10
A01N 37/18
A61K 38/08
C07K 16/00
A61P 31/04
A01P 1/00

US Classification:

514 12, 530324, 530326, 530325, 530327, 530328, 514 13, 514 14, 514 16, 5303917

Abstract:

This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.