Jian Tan

US Patent:

8252549, Aug 28, 2012

Filed:

Nov 25, 2009

Appl. No.:

12/625952

Inventors:

Hongwei Hanna Rao - Horseheads NY, US
Jian Tan - Ithaca NY, US

Assignee:

Corning Incorporated - Corning NY

International Classification:

C12Q 1/04

US Classification:

435 34, 435176

Abstract:

Described herein are multi-purpose substrates composed of (1) a base coated with a calcium phosphate coating and (2) a fluorophore-labeled collagen adsorbed on the calcium phosphate coating. The multi-purpose substrates are useful in culturing and studying the activity of a variety of cells. The multi-purpose substrates described herein can be used for both solution- and image-based analysis of cultured cells. New methods for producing and using such coated substrates are also disclosed.

US Patent:

8512741, Aug 20, 2013

Filed:

Sep 4, 2007

Appl. No.:

12/439398

Inventors:

Jian Tan - Ithaca NY, US
Yong L. Joo - Ithaca NY, US

Assignee:

Cornell Research Foundations, Inc. - Ithaca NY

International Classification:

A61F 13/00
A61F 2/00
A61C 8/00

US Classification:

424443, 424422, 424423, 4332011

Abstract:

Calcium-phosphate nanofiber matrices comprising randomly dispersed crystalline calcium-phosphate nanofibers are provided. The nanofibers are synthesized using sol-gel methods combined with electrospinning. The nanofibers may be hollow, solid or may comprise a calcium-phosphate shell surrounding a polymer containing inner core to which biologically functional additives may be added. The nanofiber matrices may be used to culture bone and dental cells, and as implants to treat bone, dental or periodontal diseases and defects.

US Patent:

20110294142, Dec 1, 2011

Filed:

Jul 29, 2010

Appl. No.:

12/846209

Inventors:

Joydeep Lahiri - Painted Post NY, US
Hongwei Hanna Rao - Horseheads NY, US
Jian Tan - Ithaca NY, US

International Classification:

G01N 33/574
B05D 1/36
G01N 33/50

US Classification:

435 723, 435 72, 435 721, 427414

Abstract:

Described herein are multiply-fluorescently-labeled calcium phosphate protein substrates composed of a base coated with a fluorophore-labeled calcium phosphate coating and further having a fluorescently-labeled protein. The multiply-fluorescently-labeled substrate may be a fluorescently labeled calcium phosphate surface having a fluorescently-labeled collagen. The substrates are useful in culturing and studying the activity of a variety of cells, including bone cells. The substrates described herein can be used for both solution- and image-based analysis of cultured cells. New methods for producing and using such coated substrates are also disclosed.

US Patent:

20110294151, Dec 1, 2011

Filed:

Jul 29, 2010

Appl. No.:

12/846043

Inventors:

Hongwei Hanna Rao - Horseheads NY, US
Jian Tan - Ithaca NY, US

International Classification:

C12Q 1/02
C07F 9/572
B32B 27/32
B05D 3/06
B32B 17/06
B32B 9/04
C12M 1/34
B05D 3/02
C07F 9/09
B32B 27/36

US Classification:

435 29, 549220, 558177, 558178, 552201, 552203, 540145, 428523, 428412, 428522, 428432, 428446, 428701, 4352881, 427384, 427551, 4352883

Abstract:

Described herein are substrates composed of a base coated with a fluorophore-labeled calcium phosphate coating. The substrates are useful in culturing and studying the activity of a variety of cells. The substrates described herein can be used for both solution- and image-based analysis of cultured cells. New methods for producing and using such coated substrates are also disclosed.

US Patent:

20120295353, Nov 22, 2012

Filed:

May 14, 2012

Appl. No.:

13/470536

Inventors:

Yulong Hong - Painted Post NY, US
Thomas Mark Leslie - Horseheads NY, US
Hui Su - Big Flats NY, US
Jian Tan - Ithaca NY, US

International Classification:

C12N 5/071
B29C 35/08
B29C 41/00
B05D 7/00
B05D 3/06

US Classification:

435402, 427517, 264496

Abstract:

Disclosed are methods of making and using polymers compositions. The polymer compositions may have monomer/oligomer mixtures that may have at least one silicone monomer or oligomer and at least one non-silicone monomer or oligomer, at least one crosslinker, and/or at least one polymerization initiator. The polymer compositions are cured, after which they may be useful in bioapplications, such as for use as freestanding films or coatings on a substrate, such as a mold, for cell culture.

US Patent:

20130029422, Jan 31, 2013

Filed:

Jul 26, 2011

Appl. No.:

13/190589

Inventors:

Vasiliy Nikolaevich Goral - Painted Post NY, US
Yulong Hong - Painted Post NY, US
Hui Su - Big Flats NY, US
Jian Tan - Ithaca NY, US

International Classification:

C12N 5/071
C12N 1/20
C12N 1/16
C12N 5/04

US Classification:

435402, 435410, 4352521, 4352551

Abstract:

A cell culture article comprises a substrate having a micro-structured surface and a thin hydrophobic elastomeric coating disposed on the substrate. The coating forms a micro-structured cell culture surface and is sufficiently thin to reduce absorption of hydrophobic molecules from an aqueous medium in contact with the coating, relative to articles fabricated entirely from the hydrophobic elastomer.

US Patent:

20140141503, May 22, 2014

Filed:

May 13, 2013

Appl. No.:

13/892697

Inventors:

- Corning NY, US
Jennifer Lynn Hunt - Addison NY, US
Meenal Pauddar Soni - Painted Post NY, US
Hui Su - Elmira NY, US
Jian Tan - Ithaca NY, US

International Classification:

C12M 1/00

US Classification:

4352891, 427256

Abstract:

An article for culturing cells includes (i) a substrate having a surface; (ii) a plurality of pillars extending from the surface of the substrate; and (iii) a polymeric coating disposed on the surface of the substrate between the pillars, forming a plurality of mini-menisci on the surface of the substrate between the plurality of pillars. The mini-menisci may have diameters of from about 20 to about 250 micrometers. The plurality of pillars are spaced apart from one another in a manner to encourage cell growth on the mini-menisci rather than the on top of the pillars. Such articles may effectively address issues associated with the meniscus effect on a global scale.