Jian Fang Wang

US Patent:

8492349, Jul 23, 2013

Filed:

Feb 29, 2012

Appl. No.:

13/408734

Inventors:

Hoau-Yan Wang - Philadelphia PA, US
Lindsay Burns Barbier - Palo Alto CA, US
Jian Wang - San Diego CA, US

Assignee:

Pain Therapeutics, Inc. - Austin TX

International Classification:

A61K 38/08

US Classification:

514 218

Abstract:

A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W—[XXX. . . XXX]ValAlaXGlyLeu[XXX. . . XXX]—Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.

US Patent:

20030096408, May 22, 2003

Filed:

Nov 13, 2002

Appl. No.:

10/293454

Inventors:

David Gerber - Chapel Hill NC, US
Jian Wang - Chapel Hill NC, US

International Classification:

C12N005/08

US Classification:

435/370000, 435/366000

Abstract:

A cell support system useful for the implantation of living cells in a subject comprises a solid substrate, typically formed from a biologically inert material. The substrate has a textured surface portion, with the textured surface portion defining a plurality of recessed cavities therein. A plurality of live cells to be implanted are deposited on the textured surface portion so that the cells (or progeny thereof) are protected from mechanical dislodgment.

US Patent:

20090034361, Feb 5, 2009

Filed:

May 13, 2008

Appl. No.:

12/119869

Inventors:

Duy K. TRANG - San Jose CA, US
Matthieu E. Peterschmitt - San Jose CA, US
Raul A. Martin - San Jose CA, US
M. Usman Ghani - Naperville IL, US
Jian Wang - Newark DE, US
Jeffrey E. Lorelli - Fremont CA, US
Axel Soulet - Oakland CA, US
Christophe Colin - Union City CA, US
Ronald S. Inman - Brookfield IL, US

International Classification:

B01F 15/02
B01F 15/04

US Classification:

3661521, 3661671, 3661651

Abstract:

Methods and fluid delivery systems mix fluids together. A blender of the system receives and blends at least two chemical compounds together for delivery to one or more vessels, tanks or process tools, such as chemical baths that facilitate processing (e.g., cleaning) of semiconductor wafers or other components. A first fluid enters into a bore of a mixing chamber of the blender through an aperture in a wall of the chamber to enable blending of the first fluid with a second fluid injected into a central region of the bore.

US Patent:

20090123993, May 14, 2009

Filed:

Mar 30, 2006

Appl. No.:

11/909858

Inventors:

Albert J. Banes - Hillsborough NC, US
Jian Wang - Durham NC, US
Jie Qi - Chapel Hill NC, US
Kamyar Kheradpir - Durham NC, US

Assignee:

MEDTRAIN TECHNOLOGIES, LLC - Hillsborough NC

International Classification:

A01N 1/02

US Classification:

4352841

Abstract:

The present invention provides a blood vessel bioreactor and accessory system to harvest, maintain, transport, and/or develop a native blood vessel or a tissue-engineered biosynthetic blood vessel construct in which regulated nutritive fluid flow as well as a pressure and shear stress regimen is supplied which nutritionally and mechanically conditions the native or tissue-engineered blood vessel construct to withstand an in vitro or in vivo environment. The present invention includes a blood vessel harvest and carriage cassette () which allows for the isolation of a blood vessel segment in situ, engagement of a defined length and bore size of the blood vessel segment with a blood vessel attachment/engagement cuff (), severing of the blood vessel segment, attachment of the severed ends of the blood vessel segment with various types of blood vessel inlet/outlet cuff connectors that connect to a nutritive fluid flow system, and a cassette-type bioreactor cartridge.

US Patent:

20090191579, Jul 30, 2009

Filed:

Oct 31, 2008

Appl. No.:

12/263257

Inventors:

Hoau-Yan Wang - Philadelphia PA, US
Lindsay Burns Barbier - Palo Alto CA, US
Jian Wang - Groton CT, US

International Classification:

C12Q 1/48
C07K 14/00
C07K 7/08
C07K 7/06
C07K 16/00
G01N 33/566
C12Q 1/02

US Classification:

435 15, 530330, 530324, 530326, 5303879, 436501, 435 29

Abstract:

A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W-[XXX. . . XXX]ValAlaXGlyLeu[XXX. . . XXX]-Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.

US Patent:

20100041128, Feb 18, 2010

Filed:

Jan 8, 2009

Appl. No.:

12/350531

Inventors:

Albert J. Banes - Hillsborough NC, US
Jian Wang - Durham NC, US
Michelle E. Wall - Apex NC, US

Assignee:

MedTrain Technologies, LLC - Hillsborough NC

International Classification:

C12M 3/00

US Classification:

4352879, 4352891, 4352941, 4352971

Abstract:

The present invention provides a cell culture device for applying shear stress and strain on single cells. The device includes at least one channel, at least one cell culture chamber having at least one single-cell attachment surface, a flexible membrane, at least one vacuum channel, and an inlet and an outlet. The inventive single-cell culture assembly fluid flow for applying fluid induced stress and/or substrate induced stress to cultured cells.