Jian Yong Wang

US Patent:

8375014, Feb 12, 2013

Filed:

Jun 19, 2009

Appl. No.:

12/488506

Inventors:

Mark Brocato - Baltimore MD, US
Jian Wang - Germantown MD, US
Steve Hsing-Yu Chen - Ellicott City MD, US

Assignee:

BioFortis, Inc. - Columbia MD

International Classification:

G06F 7/00

US Classification:

707705, 707805, 715700, 715968

Abstract:

A schema parser may determine one or more datasets of a database schema, wherein the datasets include one or more fields from a data source and represents data corresponding to the one or more fields. An input handler may receive a selection of one or more of the datasets via an interface. A translation engine may provide operations for refining the data of the selected datasets into a result set via a query, wherein the operations may be determined based on metadata defining relationships amongst the data sources and fields. A query engine may provide a graphical query including operational flow indicators indicating a directional flow of the query from the selected datasets with the selected operation to the result set.

US Patent:

8492349, Jul 23, 2013

Filed:

Feb 29, 2012

Appl. No.:

13/408734

Inventors:

Hoau-Yan Wang - Philadelphia PA, US
Lindsay Burns Barbier - Palo Alto CA, US
Jian Wang - San Diego CA, US

Assignee:

Pain Therapeutics, Inc. - Austin TX

International Classification:

A61K 38/08

US Classification:

514 218

Abstract:

A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W—[XXX. . . XXX]ValAlaXGlyLeu[XXX. . . XXX]—Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.

US Patent:

8637435, Jan 28, 2014

Filed:

Nov 14, 2008

Appl. No.:

12/291889

Inventors:

Kevin Caili Wang - Lansdale PA, US
Peter Peizhi Luo - Lansdale PA, US
Pingyu Zhong - Blue Bell PA, US
Jian Wang - Lansdale PA, US

Assignee:

Merck Sharp & Dohme Corp. - Rahway NJ

International Classification:

C40B 40/02
C40B 50/06

US Classification:

506 26, 506 14

Abstract:

The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.

US Patent:

20090191579, Jul 30, 2009

Filed:

Oct 31, 2008

Appl. No.:

12/263257

Inventors:

Hoau-Yan Wang - Philadelphia PA, US
Lindsay Burns Barbier - Palo Alto CA, US
Jian Wang - Groton CT, US

International Classification:

C12Q 1/48
C07K 14/00
C07K 7/08
C07K 7/06
C07K 16/00
G01N 33/566
C12Q 1/02

US Classification:

435 15, 530330, 530324, 530326, 5303879, 436501, 435 29

Abstract:

A composition and method are disclosed that utilize an isolated polypeptide or analog thereof to inhibit the interaction of a mu-opioid receptor with filamin A. A contemplated polypeptide has an amino acid residue sequence illustrated by the formula: W-[XXX. . . XXX]ValAlaXGlyLeu[XXX. . . XXX]-Y, wherein the various elements are defined elsewhere. A contemplated method can be used to select a VAKGL-binding compound.

US Patent:

20120329679, Dec 27, 2012

Filed:

Mar 23, 2012

Appl. No.:

13/428680

Inventors:

Kevin Caili Wang - Lansdale PA, US
Peter Peizhi Luo - Lansdale PA, US
Pingyu Zhong - Blue Bell PA, US
Jian Wang - Lansdale PA, US

Assignee:

MERCK SHARP & DOHME CORP. - Rahway NJ

International Classification:

C40B 50/06
C12N 15/63
C12N 1/19
C12N 5/10

US Classification:

506 26, 435325, 4353201, 4352542

Abstract:

The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.