Jian Y Wang

US Patent:

20030096408, May 22, 2003

Filed:

Nov 13, 2002

Appl. No.:

10/293454

Inventors:

David Gerber - Chapel Hill NC, US
Jian Wang - Chapel Hill NC, US

International Classification:

C12N005/08

US Classification:

435/370000, 435/366000

Abstract:

A cell support system useful for the implantation of living cells in a subject comprises a solid substrate, typically formed from a biologically inert material. The substrate has a textured surface portion, with the textured surface portion defining a plurality of recessed cavities therein. A plurality of live cells to be implanted are deposited on the textured surface portion so that the cells (or progeny thereof) are protected from mechanical dislodgment.

US Patent:

20090123993, May 14, 2009

Filed:

Mar 30, 2006

Appl. No.:

11/909858

Inventors:

Albert J. Banes - Hillsborough NC, US
Jian Wang - Durham NC, US
Jie Qi - Chapel Hill NC, US
Kamyar Kheradpir - Durham NC, US

Assignee:

MEDTRAIN TECHNOLOGIES, LLC - Hillsborough NC

International Classification:

A01N 1/02

US Classification:

4352841

Abstract:

The present invention provides a blood vessel bioreactor and accessory system to harvest, maintain, transport, and/or develop a native blood vessel or a tissue-engineered biosynthetic blood vessel construct in which regulated nutritive fluid flow as well as a pressure and shear stress regimen is supplied which nutritionally and mechanically conditions the native or tissue-engineered blood vessel construct to withstand an in vitro or in vivo environment. The present invention includes a blood vessel harvest and carriage cassette () which allows for the isolation of a blood vessel segment in situ, engagement of a defined length and bore size of the blood vessel segment with a blood vessel attachment/engagement cuff (), severing of the blood vessel segment, attachment of the severed ends of the blood vessel segment with various types of blood vessel inlet/outlet cuff connectors that connect to a nutritive fluid flow system, and a cassette-type bioreactor cartridge.

US Patent:

20100041128, Feb 18, 2010

Filed:

Jan 8, 2009

Appl. No.:

12/350531

Inventors:

Albert J. Banes - Hillsborough NC, US
Jian Wang - Durham NC, US
Michelle E. Wall - Apex NC, US

Assignee:

MedTrain Technologies, LLC - Hillsborough NC

International Classification:

C12M 3/00

US Classification:

4352879, 4352891, 4352941, 4352971

Abstract:

The present invention provides a cell culture device for applying shear stress and strain on single cells. The device includes at least one channel, at least one cell culture chamber having at least one single-cell attachment surface, a flexible membrane, at least one vacuum channel, and an inlet and an outlet. The inventive single-cell culture assembly fluid flow for applying fluid induced stress and/or substrate induced stress to cultured cells.