Jingxin Wang from Lawrence, KS, age 48

Us Patents

Hybrid Cyclic Libraries And Screens Thereof
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US Patent:

20140073581, Mar 13, 2014
Filed:

Nov 29, 2011
Appl. No.:

13/990396
Inventors:

Jun O. Liu - Clarkesville MD, US
Jingxin Wang - Baltimore MD, US
Zufeng Guo - Baltimore MD, US
Wei Li - Xiangtan, CN
Shridhar Bhat - Cockeysville MD, US
Manisha Das - Centerville VA, US
International Classification:

G01N 33/566
C07K 17/08
US Classification:

514 193, 506 9, 506 15, 506 23, 530323, 514 211
Abstract:

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Rapaglutins, Novel Inhibitors Of Glut And Use Thereof
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US Patent:

20210214390, Jul 15, 2021
Filed:

Feb 3, 2017
Appl. No.:

16/074300
Inventors:

- Baltimore MD, US
Jingxin Wang - Baltimore MD, US
Zufeng Guo - Baltimore MD, US
International Classification:

C07K 5/103
A61K 9/00
A61K 45/06
A61K 31/12
A61K 31/407
A61K 31/235
A61K 31/167
A61K 31/353
A61K 31/4406
A61K 38/12
C07K 5/117
A61P 35/00
Abstract:

Compounds with the following structuresand their analogs are provided. Compositions that include these structures can be used to inhibit glucose transporters and stop or decrease the proliferation of cancer, treat possible organ rejection and treat autoimmune disease.

Rapadocins, Inhibitors Of Equilibrative Nucleoside Transporter 1 And Uses Thereof
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US Patent:

20200392182, Dec 17, 2020
Filed:

Aug 26, 2020
Appl. No.:

17/003940
Inventors:

- Baltimore MD, US
Jingxin Wang - Baltimore MD, US
Zhaoli Sun - Baltimore MD, US
Sam Hong - Baltimore MD, US
International Classification:

C07K 5/103
C07D 498/18
C07D 519/00
A61K 47/54
A61K 38/07
Abstract:

A compound of Formula I,and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Hybrid Cyclic Libraries And Screens Thereof
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US Patent:

20190389911, Dec 26, 2019
Filed:

Sep 6, 2019
Appl. No.:

16/563633
Inventors:

- Baltimore MD, US
Jingxin Wang - Baltimore MD, US
Zufeng Guo - Baltimore MD, US
Wei Li - Xiangtan, CN
Shridhar Bhat - Cockeysville MD, US
Manisha Das - Centreville VA, US
International Classification:

C07K 7/64
C07K 17/08
C07D 498/04
C07D 515/14
C07D 515/04
C07D 498/14
G01N 33/566
C07D 471/04
A61K 31/4353
A61K 31/436
Abstract:

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Synthesis And Composition Of Rapafucin Libraries
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US Patent:

20190092808, Mar 28, 2019
Filed:

Feb 3, 2017
Appl. No.:

16/074017
Inventors:

- Baltimore MD, US
Jingxin Wang - Baltimore MD, US
Zufeng Guo - Baltimore MD, US
Sam Hong - Baltimore MD, US
Wukun Liu - Baltimore MD, US
Hanjing Peng - Baltimore MD, US
Manisha Das - Baltimore MD, US
International Classification:

C07K 1/04
C07K 5/10
C07K 17/08
G01N 33/574
G01N 33/68
Abstract:

A Rapafucin library containing compounds of the general structure, (A) and (E), and a synthesis of these compounds are provided.

Rapadocins, Inhibitors Of Equilibrative Nucleoside Transporter 1 And Uses Thereof
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US Patent:

20190031716, Jan 31, 2019
Filed:

Feb 3, 2017
Appl. No.:

16/073746
Inventors:

- Baltimore MD, US
Jingxin Wang - Baltimore MD, US
Zhaoli Sun - Baltimore MD, US
Sam Hong - Baltimore MD, US
International Classification:

C07K 5/103
A61K 47/54
A61K 38/07
Abstract:

A compound of Formula (I), and its analogs are provided. Compositions that include Formula I can be used to inhibit human equilibrative nucleoside transporter 1, increase adenosine signaling and produce effects that include increasing antiviral activity, increasing antiparasitic activity, increasing alcohol tolerance, decreasing pain protecting from ischemia as well as many other conditions.

Hybrid Cyclic Libraries And Screens Thereof
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US Patent:

20180222942, Aug 9, 2018
Filed:

Oct 9, 2017
Appl. No.:

15/728282
Inventors:

- Baltimore MD, US
Jingxin Wang - Baltimore MD, US
Zufeng Guo - Baltimore MD, US
Wei Li - Xiangtan, CN
Shridhar Bhat - Cockeysville MD, US
Manisha Das - Centreville VA, US
International Classification:

C07K 7/64
A61K 31/436
C07D 471/04
C07D 498/04
A61K 31/4353
C07D 515/04
C07D 515/14
C07K 17/08
G01N 33/566
C07D 498/14
Abstract:

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Hybrid Cyclic Libraries And Screens Thereof
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US Patent:

20160115203, Apr 28, 2016
Filed:

Jan 4, 2016
Appl. No.:

14/987653
Inventors:

- Baltimore MD, US
Jingxin Wang - Baltimore MD, US
Zufeng Guo - Baltimore MD, US
Wei Li - Xiangtan, CN
Shridhar Bhat - Cockeysville MD, US
Manisha Das - Centreville VA, US
International Classification:

C07K 7/64
G01N 33/566
Abstract:

Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.

Resumes

Assistant Professor

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Location:

San Diego, CA

Industry:

Research

Work:

Johns Hopkins University School of Medicine - Baltimore, Maryland Area since Aug 2011
Postdoctoral Fellow
King & Wood - Beijing City, China Jul 2011 - Aug 2011
Technology Specialist (intern)
University of Maryland - College Park, MD Aug 2006 - May 2011
Graduate Student

Education:

University of Maryland College Park 2006 - 2011
Ph.D, Chemistry Peking University 2002 - 2006
B.S., Chemistry Beijing No.4 High School 1999 - 2002

Skills:

Cell Culture
Organic Synthesis
Hplc
Pharmaceutical Microbiology
Molecular Cloning
Nmr
Protein Expression
Assay Development
High Throughput Screening
Cancer Biology
Computational Chemistry
Biophysics
Data Analysis
Spectroscopy
Biochemistry
Molecular Biology
Organic Chemistry
Medicinal Chemistry

Interests:

Science and Technology
Education

Languages:

English
Mandarin

Certifications:

License 54Gq349U8J