John D Chisholm

US Patent:

7255355, Aug 14, 2007

Filed:

Jan 3, 2005

Appl. No.:

11/028725

Inventors:

John Chisholm - Lawndale CA, US
Shawn Tsung - Monterey Park CA, US
Paulo Carrolo - Merritt Island FL, US

Assignee:

MK Diamond Products, Inc. - Torrance CA

International Classification:

B60N 2/28

US Classification:

280 30, 280 29, 280 4716, 280 4717, 280 4718, 280 4719, 280 472, 280 4722, 280 4724, 280 4725, 280 4727, 280 4728, 280 4733, 280 4734, 280638, 280639, 280641, 280651, 280652, 248439, 248588, 248631, 248647, 248676

Abstract:

A portable collapsible stand includes first, second, and third support frames, a work surface frame, and a telescoping strut pivotably connected to the first and work surface frames. The second frame projects perpendicularly from a lower portion of the first frame. A first end of the third frame is rotatably connected to an upper portion of the first frame such that the third frame pivots from a first parallel position to a second perpendicular position with respect to the first frame. An upper portion of the work surface frame is rotatably connected to the upper portion of the first frame. In operation, the stand can assume a collapsed position in which the first, third and work surface frames are generally parallel, and an operating position in which the third frame and first frame are perpendicular and the work surface frame and surface supporting the stand are parallel.

US Patent:

20130102577, Apr 25, 2013

Filed:

Apr 11, 2011

Appl. No.:

13/640162

Inventors:

William G. Kerr - Syracuse NY, US
John D. Chisholm - Fayetteville NY, US

Assignee:

The Research Foundation of the State University of New York - Syracuse NY

International Classification:

C07J 41/00
C07J 9/00
C07J 1/00
C07J 31/00

US Classification:

514178, 552521, 514169, 552515, 552524, 552540, 552544, 552636, 552502, 514182, 435375, 435366

Abstract:

The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

US Patent:

54002486, Mar 21, 1995

Filed:

Sep 15, 1993

Appl. No.:

8/122869

Inventors:

John D. Chisholm - Menlo Park CA

International Classification:

G06F 1520
G06F 1530

US Classification:

364409

Abstract:

A voting system allows voters to express and cast votes that are conditional on the votes of others of a voting group. Votes may be conditional on the votes of specific individuals, on the number or percent of the overall group who vote a certain way, external events or on any combination thereof. The system solves the "common goods, free rider" dilemma in which voters oppose proposals they recognize as worthwhile out of fear that a few supporters will be burdened with all of the costs. The system specifies and enforces terms under which conditional voting will take place, and may manage the voting process across a network. The system recognizes when either multiple solutions or no solutions to a set of votes exist. The system can determine which voters are responsible for these cases, and can invite them to change their votes, if they wish. The system can also determine the largest subset or subsets of a group of conditional votes that has no solution, for which there is a unique solution or multiple solutions.

US Patent:

20200376005, Dec 3, 2020

Filed:

Dec 20, 2019

Appl. No.:

16/724093

Inventors:

- Syracuse NY, US
JOHN D. CHISHOLM - FAYETTEVILLE NY, US

International Classification:

A61K 31/575
A61K 31/566
A61K 31/565
A61K 31/713
A61K 31/4045
A61K 31/4709
A61K 31/473
A61K 31/568
A61K 31/5685
A61K 31/655
C12N 15/113

Abstract:

The present invention relates to the use of SHIP1 inhibitors and pan-SHIP1/2 inhibitors in various methods, including, without limitation: (i) a method to treat obesity or reduce body fat of an obese subject; (ii) a method to limit bone development in a subject suffering from an osteopetrotic or sclerotic disease; (iii) a method to treat or prevent diabetes; (iv) a method to reduce glucose intolerance or insulin resistance; and (v) a method to lower cholesterol.

US Patent:

20190224214, Jul 25, 2019

Filed:

Aug 15, 2017

Appl. No.:

16/324985

Inventors:

James L. Hougland - Fayetteville NY, US
John D. Chisholm - Fayetteville NY, US

Assignee:

SYRACUSE UNIVERSITY - SYRACUSE NY

International Classification:

A61K 31/566
A61K 31/122
A61P 3/04

Abstract:

A class of cyanosteroid compounds that efficiently inhibit ghrelin acylation by ghrelin O-acyltransferase. The compounds have a steroid scaffold with α,β-unsaturated ketone in the A ring position such an α-cyanoenone. Exemplary compounds include (5S,8S,9S,10S,13S,14S)-10,13-dimethyl-3-oxo-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthrene-2-carbonitrile.

US Patent:

20170189380, Jul 6, 2017

Filed:

Dec 30, 2016

Appl. No.:

15/396272

Inventors:

- Syracuse NY, US
John D. Chisholm - Fayetteville NY, US

International Classification:

A61K 31/4045

Abstract:

The present disclosure provides compositions that inhibit the SH2-containing inositol 5′-phosphatase (SHIP), as well as methods using such compositions for use in treating or ameliorating the effects of a medical condition in a subject.

US Patent:

20170051006, Feb 23, 2017

Filed:

Sep 19, 2016

Appl. No.:

15/269209

Inventors:

- Syracuse NY, US
John D. Chisholm - Syracuse NY, US

Assignee:

The Research Foundation For The State University of New York - Syracuse NY

International Classification:

C07J 1/00
C07J 41/00

Abstract:

The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.