John R Chisholm

US Patent:

20130102577, Apr 25, 2013

Filed:

Apr 11, 2011

Appl. No.:

13/640162

Inventors:

William G. Kerr - Syracuse NY, US
John D. Chisholm - Fayetteville NY, US

Assignee:

The Research Foundation of the State University of New York - Syracuse NY

International Classification:

C07J 41/00
C07J 9/00
C07J 1/00
C07J 31/00

US Classification:

514178, 552521, 514169, 552515, 552524, 552540, 552544, 552636, 552502, 514182, 435375, 435366

Abstract:

The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.

US Patent:

20170051006, Feb 23, 2017

Filed:

Sep 19, 2016

Appl. No.:

15/269209

Inventors:

- Syracuse NY, US
John D. Chisholm - Syracuse NY, US

Assignee:

The Research Foundation For The State University of New York - Syracuse NY

International Classification:

C07J 1/00
C07J 41/00

Abstract:

The present invention relates to SHIP inhibitor compounds and methods for using these compounds. In particular, the present invention discloses the following methods: (i) a method of treating graft versus host disease in a subject; (ii) a method of inhibiting a SHIP1 protein in a cell; (iii) a method of selectively inhibiting a SHIP1 protein in a cell; (iv) a method for treating or preventing graft-versus-host disease (GVHD) in a recipient of an organ or tissue transplant; (v) a method of modulating SHIP activity in a cell expressing SHIP1 or SHIP2; (vi) a method of ex vivo or in vitro treatment of transplants; (vii) a method of inhibiting tumor growth and metastasis in a subject; (viii) a method of treating a hematologic malignancy in a subject; (ix) a method of inducing apoptosis of multiple myeloma cells; (x) a method of treating multiple myeloma in a subject; (xi) a method of inhibiting the proliferation of a human breast cancer cell; and (xii) a method of treating breast cancer in a subject.