John Robert Hackett

US Patent:

7615613, Nov 10, 2009

Filed:

Dec 12, 2007

Appl. No.:

11/954351

Inventors:

John R. Hackett - Libertyville IL, US
Julie Yamaguchi - Chicago IL, US
Alan M. Golden - Wilmette IL, US
Catherine A. Brennan - Libertyville IL, US
Robert K. Hickman - Mundelein IL, US
Sushil G. Devare - Northbrook IL, US

Assignee:

Abbott Laboratories, Inc. - Abbott Park IL

International Classification:

C07K 14/16

US Classification:

530350, 530300

Abstract:

Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.

US Patent:

20030148280, Aug 7, 2003

Filed:

Sep 4, 2001

Appl. No.:

09/945943

Inventors:

Barbara Harris - Gurnee IL, US
John Hackett - Libertyville IL, US
Priscilla Swanson - Libertyville IL, US
Klara Abravaya - Wilmette IL, US
Sushil Devare - Northbrook IL, US
Jacek Gorzowski - Mundelein IL, US
Claudia Esping - Geneva IL, US
Ning Tang - Libertyville IL, US

International Classification:

C12Q001/70
C12Q001/68
C07H021/04

US Classification:

435/006000, 435/005000, 536/023720, 536/024320, 536/024330

Abstract:

Oligonucleotide primer sets, probes, and combinations of the primer sets and probes are provided herein. These reagents are useful for amplifying and detecting HIV-1 target sequences in a test sample.

US Patent:

20050227257, Oct 13, 2005

Filed:

Nov 30, 2004

Appl. No.:

10/999760

Inventors:

Klara Abravaya - KenilWorth IL, US
John Hackett - Libertyville IL, US
Shihai Huang - Evanston IL, US
Ka-Cheung Luk - Lake Bluff IL, US
John Salituro - Union Grove WI, US
Larry Morrison - Glen Ellyn IL, US

International Classification:

C12Q001/68
C07H021/04

US Classification:

435006000, 536024300

Abstract:

A double-stranded nucleic acid hybridization probe and methods of using the same are described. The probe described is particularly suited for real-time RT-PCR reactions and has high tolerance to mismatches.

US Patent:

20060153866, Jul 13, 2006

Filed:

Dec 9, 2004

Appl. No.:

11/008351

Inventors:

John Hackett - Libertyville IL, US
Julie Yamaguchi - Chicago IL, US
Alan Golden - Wilmette IL, US
Catherine Brennan - Libertyville IL, US
Robert Hickman - Mundelein IL, US
Sushil Devare - Northbrook IL, US

International Classification:

A61K 39/21
C07K 14/16

US Classification:

424188100, 530350000

Abstract:

Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.

US Patent:

20080090226, Apr 17, 2008

Filed:

Dec 12, 2007

Appl. No.:

11/954356

Inventors:

John Hackett - Libertyville IL, US
Julie Yamaguchi - Chicago IL, US
Alan Golden - Wilmette IL, US
Catherine Brennan - Libertyville IL, US
Robert Hickman - Mundelein IL, US
Shushil Devare - Northbrook IL, US

International Classification:

C07H 21/04
C07K 16/00
C12N 15/00
C12N 5/02
C12Q 1/70

US Classification:

435005000, 435252330, 435320100, 530350000, 530388350, 536023530

Abstract:

Isolated HIV-1 Group O env polypeptides obtained from the HIV-1 isolate HAM112 are claimed, as well as (a) antigen constructs comprising fusions of one or more of each of HIV-1 Group O env polypeptides and HIV-1 Group M env polypeptide and (b) further antigen constructs containing additional Group O sequences and especially the gp41 IDR of isolate HAM112. Also claimed are polynucleotide sequences encoding the above, expression vectors comprising the same, host cells transformed thereby, and immunoassay methods and kits utilizing the antigen constructs of the invention.

US Patent:

60156627, Jan 18, 2000

Filed:

Jan 23, 1996

Appl. No.:

8/589939

Inventors:

John R. Hackett - Gurnee IL
Jane A. Hoff - Naperville IL
David H. Ostrow - Lake Zurich IL
Alan M. Golden - Wilmette IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

G01N 33569
G01N 33577

US Classification:

435 5

Abstract:

The present invention relates to the use of a reagent that binds specifically to a predetermined ligand, contains one or more antibody constant region epitopes, and is uniform in specificity and affinity. The reagent can be produced continually, in the manufacture of calibrators (standards) and/or controls for diagnostic kits designed to qualitatively or quantitatively measure antibodies specific for a desired ligand. For example, the present invention encompasses recombinant mouse-human chimeric antibodies which may be used as calibrators (standards) and/or positive controls in assays and kits which measure human antibodies. Any species may be used in creating the chimeric antibodies, and the presence of any corresponding species of antibody may be detected.

US Patent:

59225335, Jul 13, 1999

Filed:

Aug 15, 1997

Appl. No.:

8/912129

Inventors:

Anadruzela S. Vallari - Libertyville IL
John R. Hackett - Libertyville IL
Robert K. Hickman - Mundelein IL
Vincent A. Varitek - Wildwood IL
Elizabeth C. Necklaws - Grayslake IL
Alan M. Golden - Wilmette IL
Catherine A. Brennan - Libertyville IL
Sushil G. Devare - Northbrook IL

Assignee:

Abbott Laboratories - Abbott Park IL

International Classification:

C12Q 170

US Classification:

435 5

Abstract:

A method of performing a rapid assay for the simultaneous detection and differentiation of the analytes HIV-1 group M. HIV-1 group O and HIV-2 utilizing a sequence specific polypeptide of each analyte as capture reagents. An analytical. device also is provided for performing the method which includes these capture reagents. Also provided is a test kit which includes the analytical device which further can include a positive and negative control.

US Patent:

20160289749, Oct 6, 2016

Filed:

Jun 13, 2016

Appl. No.:

15/180357

Inventors:

- Des Plaines IL, US
John R. Hackett - Libertyville IL, US
Shihai X. Huang - Lincolnshire IL, US
Ka-Cheung X. Luk - Lake Bluff IL, US
John A. Salituro - Union Grove WI, US
Larry E. Morrison - Oro Valley AZ, US

International Classification:

C12Q 1/68

Abstract:

A double-stranded nucleic acid hybridization probe and methods of using the same are described. The probe described is particularly suited for real-time RT-PCR reactions and has high tolerance to mismatches.