John H Regan

Address:

1151 Bloomdale Rd, Philadelphia, PA 19115

Phone:

(215)7257734

VIN:

1ZVFT82H975209119

Make:

FORD

Model:

MUSTANG

Year:

2007

US Patent:

6800645, Oct 5, 2004

Filed:

Jul 7, 2000

Appl. No.:

09/612530

Inventors:

Paul Joseph Cox - Dagenham, GB
Shelley Bower - Dagenham, GB
David John Aldous - Dagenham, GB
Peter Charles Astles - Dagenham, GB
Daniel Gerard McGarry - King of Prussia PA
Christopher Hulme - Phoenixville PA
John Robinson Regan - Larchmont NY
Fu-Chih Huang - North Wales PA
Stevan Wakefield Djuric - Libertyville IL
Kevin Joseph Moriarty - Norristown PA
Rose Mappilakunnel Mathew - Phoenixville PA
Gregory Bernard Poli - Perkasie PA

Assignee:

Aventis Pharma Limited - Kent

International Classification:

A61K 3147

US Classification:

514314, 514308, 514309, 514312, 514313, 546169, 546140, 546141, 546146, 546153, 546156, 546158, 546159, 546165, 546166

Abstract:

This invention is directed to physiologically active compounds of formula (I) wherein represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring is an azaheterocycle, and the ring represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; R represents hydrogen or a straight- or branched-chain alkyl group of 1 to about 4 carbon atoms, optionally substituted by hydroxy or one or more halogen atoms, or when Z represents a direct bond R may also represent a lower alkenyl or lower alkynyl group, or a formyl group; R represents hydrogen, alkenyl, alkoxy, alkyl, alkylsulphinyl, alkylsulphonyl, alkylthio, aryl, arylalkyloxy, arylalkylsulphinyl, arylalkylsulphonyl, arylalkylthio, aryloxy, arylsulphinyl, arylsulphonyl, arylthio, cyano, cycloalkenyl, cycloalkenyloxy, cycloalkyl, cycloalkyloxy, heteroaryl, heteroarylalkyloxy, heteroaryloxy, hydroxy, âSO NR R , âNR SO R , âNR R , âC( O)R , âC( O)C( O)R , âC( O)NR R , âC( O)OR , âO(C O)NR R , or âNR C( O)R ; R represents âC( Z)âN(R )R , âC( Z)âCHR R , âC( Z)âR , âCR C(R )(CH ) âR , âC(R ) C(R )R , âC(R )(R )C(R )(R )R , âC(R )(R )CH(R )(CH ) âR , âR , âV( Z)âR , âC(R ) NâOC( O)R , âC( O)âN(R )OR , âCâCâR , âCH âC( Z)âR , âC( Z)âC( Z)R , âCH âNHR , âCH âZR , âCH âSOR , âCH âSO R , âCF âOR , âNHâCH R , âZâCH R , âSOâCH R , âSO âCH R , âOâCF R , âOâC( Z)R , âN NâR , âNHâSO R , âSO âNR R , âCZâCZâNHR , âNHâCOâOR , âOâCOâNHR , âNHâCOâNHR , âR , âCX CX R , âC( NOR ), â(CH ) R , âCH âCOâNH(CH ) R , âCH âNHâCO(CH ) R , âCH âCOâCH R , âC( NR )âNH(CH ) R , âC(X ) Nâ(CH ) R or âCH(X )âCH R ; A represents a direct bond, or a straight or branched C alkylene chain optionally substituted by hydroxyl, alkoxy, oxo, cycloalkyl, aryl or heteroaryl, or A represents a straight or branched C alkenylene or C alkynylene chain; Z represents a direct bond, an oxygen or sulphur atom or NH; n and m each represent zero or 1, provided that n is 1 when m is zero and n is zero when m is 1; and N-oxides thereof, and their prodrugs, and pharmaceutically acceptable salts and solvates of the compounds of formula (I) and N-oxides thereof, and their prodrugs. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.

US Patent:

6821280, Nov 23, 2004

Filed:

Aug 3, 2000

Appl. No.:

09/631502

Inventors:

Charanpreet S. Bagga - Malvern PA 19355
Eric Gray - Rockford MN 55373
John E. Regan - Brentwood CA 90049

International Classification:

A61B 1702

US Classification:

606 80, 606 61

Abstract:

An instrument for cutting and/or curetting during surgery is discosed. The instruments of the invention are particularly advantageous for use in removing disc material from an intervertebral disc space. In a preferred embodiment, rotation of the instrument around a longitudinal axis of the instrument provides for intermittently distracting vertebrae adjacent to the intervertebral disc space during rotation.

US Patent:

48639575, Sep 5, 1989

Filed:

Dec 21, 1987

Appl. No.:

7/135805

Inventors:

Kent W. Neuenschwander - Ambler PA
John R. Regan - Princeton NJ
Benedict J. Kosmider - Audubon PA

Assignee:

Rorer Pharmaceutical Corporation - Fort Washington PA

International Classification:

A61K 31365
C07D30920

US Classification:

514460

Abstract:

Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically acceptable salts thereof. Pharmaceutical compositions containing said compounds and method of inhibiting the biosynthesis of cholesterol therewith are also disclosed.

US Patent:

52160157, Jun 1, 1993

Filed:

Feb 5, 1991

Appl. No.:

7/650494

Inventors:

Daniel G. McGarry - King of Prussia PA
Francis A. Volz - Philadelphia PA
John R. Regan - Princeton NJ
Michael N. Chang - Newtown PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

A61K 31365
C07D30930

US Classification:

514460

Abstract:

This invention relates to compounds which are steroidyl derivatives of 4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one and the corresponding ring-opened hydroxy acid form thereof which are useful as antihypercholesterolemic agents, to pharmaceutical compositions including such compounds, and to their use in treating hypercholesterolemia.

US Patent:

63036002, Oct 16, 2001

Filed:

Dec 18, 1998

Appl. No.:

9/216392

Inventors:

Paul Joseph Cox - Dagenham, GB
David John Aldous - Dagenham, GB
Daniel Gerard McGarry - King of Prussia PA
Christopher Hulme - Phoenixville PA
John Robinson Regan - Larchmont NY
Fu-Chih Huang - North Wales PA
Stevan Wakefield Djuric - Libertyville IL
Kevin Joseph Moriarty - Norristown PA
Rose Mappilakunnel Mathew - Phoenixville PA
Gregory Bernard Poli - Perkasie PA

Assignee:

Rhone-Poulenc Rorer Limited - Dagenham

International Classification:

A61K 31535
A61K 3144
C07D40100
C07D41300

US Classification:

5142355

Abstract:

This invention is directed to certain physiologically active compounds of formula (I) ##STR1## wherein ##STR2## represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring ##STR3## is an azaheterocycle, and the ring ##STR4## represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; and N-oxides thereof, and their prodrugs, and pharmaceutically acceptable salts and solvates of the compounds of formula (I) and N-oxides thereof, and their prodrugs. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions comprising compounds of formula (I), their pharmaceutical use and methods for their preparation.

US Patent:

55345328, Jul 9, 1996

Filed:

Jan 25, 1995

Appl. No.:

8/378146

Inventors:

Robert A. Groneberg - Oaks PA
John R. Regan - Collegeville PA
Kent W. Neuenschwander - Schwenksville PA
Anthony C. Scotese - King of Prussia PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

A61K 31425
C07D27764
C07D27766

US Classification:

514367

Abstract:

This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

US Patent:

54552605, Oct 3, 1995

Filed:

May 21, 1993

Appl. No.:

8/065966

Inventors:

Robert A. Groneberg - Oaks PA
John R. Regan - Collegeville PA
Kent W. Neuenschwander - Schwenksville PA
Anthony C. Scotese - King of Prussia PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

A61K 3142

US Classification:

514375

Abstract:

This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.

US Patent:

55611435, Oct 1, 1996

Filed:

May 22, 1995

Appl. No.:

8/445631

Inventors:

Robert A. Groneberg - Oaks PA
John R. Regan - Collegeville PA
Kent W. Neuenschwander - Schwenksville PA
Anthony C. Scotese - King of Prussia PA

Assignee:

Rhone-Poulenc Rorer Pharmaceuticals Inc. - Collegeville PA

International Classification:

A61K 3147
C07D215227
C07D21536
C07D21538

US Classification:

514312

Abstract:

This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is further linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.