John R Richards

US Patent:

8394374, Mar 12, 2013

Filed:

Sep 18, 2007

Appl. No.:

12/441885

Inventors:

Matthew J. Bernett - Monrovia CA, US
John R. Desjarlais - Pasadena CA, US
Sher Bahadur Karki - Pomona CA, US
Gregory Alan Lazar - Arcadia CA, US
Umesh S. Muchhal - Monrovia CA, US
Duc-Hanh Thi Nguyen - Sylmar CA, US
John O. Richards - Duarte CA, US

Assignee:

Xencor, Inc. - Monrovia CA

International Classification:

A61K 39/395

US Classification:

4241301, 5303871

Abstract:

The present disclosure describes antibodies that target HM1. 24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

US Patent:

8524867, Sep 3, 2013

Filed:

Aug 14, 2007

Appl. No.:

12/377251

Inventors:

Matthew J. Bernett - Monrovia CA, US
Seung Yup Chu - Cypress CA, US
John R. Desjarlais - Pasadena CA, US
Sher Bahadur Karki - Pomona CA, US
Gregory Alan Lazar - Arcadia CA, US
Erik WeiKing Pong - Temple City CA, US
John O. Richards - Duarte CA, US
Eugene Alexander Zhukovsky - West Hollywood CA, US

Assignee:

Xencor, Inc. - Monrovia CA

International Classification:

C07K 16/00
C12P 21/08
A61K 39/00
A61K 39/40
A61K 39/395
C07K 17/00

US Classification:

5303871, 5303873, 5303877, 5303881, 53038815, 53038822, 5303887, 53038873, 5303888, 4241301, 4241321, 4241331, 4241341, 4241381, 4241401, 4241411, 4241421, 4241431, 4241441, 4241521, 4241531, 4241551

Abstract:

Antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody, and methods of using the antibodies.

US Patent:

20080219974, Sep 11, 2008

Filed:

Sep 18, 2007

Appl. No.:

11/857310

Inventors:

Matthew J. Bernett - Monrovia CA, US
John R. Desjarlais - Pasadena CA, US
Sher Bahadur Karki - Pomona CA, US
Gregory Alan Lazar - Arcadia CA, US
Umesh S. Muchhal - Monrovia CA, US
Duc-Hanh Thi Nguyen - Sylmar CA, US
John O. Richards - Duarte CA, US

International Classification:

A61K 39/395
C07K 16/18
A61P 37/00
C07H 21/00

US Classification:

4241331, 5303873, 536 2353

Abstract:

The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

US Patent:

20080260731, Oct 23, 2008

Filed:

Aug 14, 2007

Appl. No.:

11/838824

Inventors:

Matthew J. Bernett - Monrovia CA, US
Seung Yup Chu - Cypress CA, US
John R. Desjarlais - Pasadena CA, US
Sher Bahadur Karki - Pomona CA, US
Gregory Alan Lazar - Arcadia CA, US
Erik Weiking Pong - Temple City CA, US
John O. Richards - Duarte CA, US
Eugene Alexander Zhukovsky - West Hollywood CA, US

International Classification:

A61K 39/395
C07K 16/18
A61P 37/00
C07H 21/04

US Classification:

4241331, 5303873, 536 2353

Abstract:

The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

US Patent:

20120082664, Apr 5, 2012

Filed:

Aug 30, 2011

Appl. No.:

13/221811

Inventors:

Matthew J. Bernett - Monrovia CA, US
Seung Yup Chu - Cypress CA, US
John R. Desjarlais - Pasadena CA, US
Sher Bahadur Karki - Pomona CA, US
Gregory Alan Lazar - Arcadia CA, US
Erik WeiKing Pong - Temple City CA, US
John O. Richards - Duarte CA, US
Eugene Alexander Zhukovsky - West Hollywood CA, US

International Classification:

A61K 39/395
A61P 35/00
A61P 35/02
C07K 16/28
C12N 15/13

US Classification:

4241331, 4241391, 5303873, 5303879, 536 2353

Abstract:

The present invention describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcγR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

US Patent:

50932519, Mar 3, 1992

Filed:

May 23, 1986

Appl. No.:

6/866780

Inventors:

John H. Richards - Bradbury CA
Sheila A. Iverson - Pasadena CA
Dianne M. Perez - Sun Valley CA

Assignee:

California Institute of Technology - Pasadena CA

International Classification:

C12N 1510
C12N 1529
C12N 121

US Classification:

4351723

Abstract:

The method of synthesizing a segment of DNA, typically a gene, of predetermined structure which comprises synthesizing a first pair of oligonucleotides having ends complementary to the ends enzymatically made at a restriction site on a standard plasmid vector, said first pair of oligonucleotides including adjacent their ends portions of said predetermined structure and each having a pair of restriction sites internal to said portions of predetermined structure which restriction sites are unique to the enzyme and not present in the plasmid vector, cloning said first pair of oligonucleotides into said standard plasmid vector, and amplifying said plasmid vector in vivo to recover plasmid vector containing said first pair of oligonucleotides, repeating said method with a second pair of ologonucleotides, containing portions of predetermined structure which are adjacent to the portions present in the first pair of oligonucleotides, and continuing said repetition until all of said segment of predetermined structure has been cloned into said standard vector and amplified.

US Patent:

46836101, Aug 4, 1987

Filed:

May 2, 1985

Appl. No.:

6/729669

Inventors:

John O. Richards - Hemet CA
John Graef - Middleburg Heights OH

Assignee:

Universal Extension Corporation - Cleveland OH

International Classification:

B25G 104

US Classification:

16115

Abstract:

An extension for a handle of a tool or similar device includes a hollow cylindrical shaped tube formed with a series of circumferentially spaced slots that provide intervening strips of tube material adjacent to but spaced from an open end of the tube. A manually operated clamping band encircles the strips of tube material and clamps the strip against a handle inserted into the tube bore. A second pair of circumferentially spaced slots and intervening strips of the material may be formed adjacent to the first series of strips and is encircled by another clamp for increasing the grip on a handle inserted into the tube.

US Patent:

20150232822, Aug 20, 2015

Filed:

Jan 16, 2015

Appl. No.:

14/598890

Inventors:

- Carlsbad CA, US
- Pasadena CA, US
John Richards - Bradbury CA, US

Assignee:

APPLIED BIOSYSTEMS LLC - Carlsbad CA
CALIFORNIA INSTITUTE OF TECHNOLOGY - Pasadena CA

International Classification:

C12N 9/12
C12Q 1/68

Abstract:

The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one mutation in the nucleotide label interaction region of the enzyme such the mutation results in reduced discrimination against labeled nucleotides. The nucleotide label interaction regions is located at portions of the O-helix, (ii) the K helix, and (iii) the inter O-P helical loop of Taq DNA polymerase or analogous positions in other DNA polymerases.In addition to providing novel mutant DNA polymerases, the invention also provides polynucleotides encoding the subject mutant DNA polymerases. The polynucleotides provided may comprise expression vectors for the recombinant production of the mutant polymerases. The invention also provides host cells containing the subject polynucleotides. The invention also includes numerous methods of using the subject DNA polymerases, including uses for chain termination sequencing and PCR. Another aspect of the invention is to provide kits for synthesizing fluorescently labeled polynucleotides in accordance with the methods of the invention. Kits of the invention comprise a mutant DNA polymerase of the invention and a fluorescently labeled nucleotide that exhibits reduced discrimination with respect to the mutant DNA polymerase in the kit.

Address:

6976 Vinnedge Ln, Highland, CA 92346

Phone:

(909)7253797

VIN:

4T1BK3EK9BU625342

Make:

TOYOTA

Model:

CAMRY

Year:

2011