John P Richards

US Patent:

6490852, Dec 10, 2002

Filed:

Oct 23, 2000

Appl. No.:

09/693927

Inventors:

Robert V. Mustacich - Santa Barbara CA
John P. Richards - Santa Barbara CA

Assignee:

RVM Scientific, Inc. - Santa Barbara CA

International Classification:

D02G 336

US Classification:

57 3

Abstract:

An electrically insulated gas chromatograph assembly suitable for high temperature operation in a miniaturized, low power, low thermal mass gas chromatograph instrument is provided. The gas chromatograph (GC) assembly includes a metal capillary GC column ( ) having a ceramic fiber insulating layer ( ) wrapped about an outer surface thereof. Heater wire ( ) is similarly wrapped with a ceramic fiber electrical insulating layer ( ). Resistive temperature device (RTD) wire ( ) is positioned contiguous an outer surface of insulating layer ( ). The composite assembly including insulated capillary GC column ( ), insulated heater wire ( ), and RTD wire ( ), are bound together by applying thereto a spiral wrapped ceramic fiber insulating layer ( ).

US Patent:

6530260, Mar 11, 2003

Filed:

Feb 4, 2002

Appl. No.:

10/061230

Inventors:

Robert V. Mustacich - Santa Barbara CA
John P. Richards - Santa Barbara CA
James F. Everson - Santa Barbara CA

Assignee:

RVM Scientific, Inc. - Santa Barbara CA

International Classification:

G01N 100

US Classification:

73 2341, 73 2325, 2101982, 422 89

Abstract:

A gas chromatography system includes a gas chromatography oven having a door adapted for integration with gas chromatography modules which are located outside of the oven cavity. For these purposes, the oven door has module receiving openings in which the modules are secured. The gas chromatography module includes a module housing containing a main coil of the capillary column, a pair of transfer lines sleeved on the free ends of the capillary column, a heater wire wound on the transfer lines, and, optionally, a pair of chromatography connectors which extend into the oven cavity and through which the free ends of the capillary column, as well as transfer lines, projecting into the oven cavity. A wall of the GC oven has an injector port and a detector port for injection of a sample into the oven cavity and for detecting the sample constituents. Column lengths extend within the oven cavity between the module and injector and detector, respectively.

US Patent:

8394374, Mar 12, 2013

Filed:

Sep 18, 2007

Appl. No.:

12/441885

Inventors:

Matthew J. Bernett - Monrovia CA, US
John R. Desjarlais - Pasadena CA, US
Sher Bahadur Karki - Pomona CA, US
Gregory Alan Lazar - Arcadia CA, US
Umesh S. Muchhal - Monrovia CA, US
Duc-Hanh Thi Nguyen - Sylmar CA, US
John O. Richards - Duarte CA, US

Assignee:

Xencor, Inc. - Monrovia CA

International Classification:

A61K 39/395

US Classification:

4241301, 5303871

Abstract:

The present disclosure describes antibodies that target HM1. 24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

US Patent:

8524867, Sep 3, 2013

Filed:

Aug 14, 2007

Appl. No.:

12/377251

Inventors:

Matthew J. Bernett - Monrovia CA, US
Seung Yup Chu - Cypress CA, US
John R. Desjarlais - Pasadena CA, US
Sher Bahadur Karki - Pomona CA, US
Gregory Alan Lazar - Arcadia CA, US
Erik WeiKing Pong - Temple City CA, US
John O. Richards - Duarte CA, US
Eugene Alexander Zhukovsky - West Hollywood CA, US

Assignee:

Xencor, Inc. - Monrovia CA

International Classification:

C07K 16/00
C12P 21/08
A61K 39/00
A61K 39/40
A61K 39/395
C07K 17/00

US Classification:

5303871, 5303873, 5303877, 5303881, 53038815, 53038822, 5303887, 53038873, 5303888, 4241301, 4241321, 4241331, 4241341, 4241381, 4241401, 4241411, 4241421, 4241431, 4241441, 4241521, 4241531, 4241551

Abstract:

Antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody, and methods of using the antibodies.

US Patent:

20070148170, Jun 28, 2007

Filed:

Oct 3, 2006

Appl. No.:

11/538406

Inventors:

John Desjarlais - Pasadena CA, US
Sher Karki - Pasadena CA, US
Gregory Lazar - Arcadia CA, US
John Richards - Monrovia CA, US
Gregory Moore - Pasadena CA, US
David Carmichael - Monrovia CA, US

International Classification:

A61K 39/395
C07K 16/28

US Classification:

424144100, 530388220

Abstract:

The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.

US Patent:

20070275460, Nov 29, 2007

Filed:

Oct 3, 2006

Appl. No.:

11/538411

Inventors:

John Desjarlais - Pasadena CA, US
Sher Karki - Pasadena CA, US
Gregory Lazar - Arcadia CA, US
John Richards - Monrovia CA, US
Gregory Moore - Pasadena CA, US
David Carmichael - Monrovia CA, US

Assignee:

Xencor.Inc. - Monrovia CA

International Classification:

C12N 5/10
C07K 14/47
C07K 16/28

US Classification:

435325000, 530350000, 530387900

Abstract:

The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.

US Patent:

20080206867, Aug 28, 2008

Filed:

Oct 31, 2007

Appl. No.:

11/981647

Inventors:

John R. Desjarlais - Pasadena CA, US
Sher Bahadur Karki - Pasadena CA, US
Gregory Alan Lazar - Arcadia CA, US
John O. Richards - Monrovia CA, US
Gregory L. Moore - Pasadena CA, US
David F. Carmichael - Monrovia CA, US

International Classification:

C12N 5/00
C07K 16/00

US Classification:

435375, 5303871

Abstract:

The present invention relates to Fc variants with optimized Fc receptor binding properties, methods for their generation, Fc polypeptides comprising Fc variants with optimized Fc receptor binding properties, and methods for using Fc variants with optimized Fc receptor binding properties.

US Patent:

20080219974, Sep 11, 2008

Filed:

Sep 18, 2007

Appl. No.:

11/857310

Inventors:

Matthew J. Bernett - Monrovia CA, US
John R. Desjarlais - Pasadena CA, US
Sher Bahadur Karki - Pomona CA, US
Gregory Alan Lazar - Arcadia CA, US
Umesh S. Muchhal - Monrovia CA, US
Duc-Hanh Thi Nguyen - Sylmar CA, US
John O. Richards - Duarte CA, US

International Classification:

A61K 39/395
C07K 16/18
A61P 37/00
C07H 21/00

US Classification:

4241331, 5303873, 536 2353

Abstract:

The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.